Glycoscience

<p>Inhibitor of lysosomal acid β-glucosidase (GlcCerase/glucocerebrosidase) with IC50 in nanomolar range for wildtype and mutant enzyme. It behaves as pharmacological chaperon by binding to instable GlcCerase active site at neutral pH values and facilitating the protein folding. In acidic lysosomes, isofagomine gets release from the enzyme active site. This results in increased levels of functional glucocerebrosidase and brings therapeutic benefits to patients with Gaucher disease.</p>

<p>Lactose-sp-biotin is a complex carbohydrate that has been modified with biotin. It is synthesized by the click modification of lactose and spacer arm, followed by glycosylation with biotin. Lactose-sp-biotin is soluble in water, which makes it suitable for use as a food additive. This product can also be used for labeling and identification of biomolecules in various fields such as fluorescence, immunoassay, or immunohistochemistry.</p>

Food additive; soil suspension polymer in detergents; thickening agent

<p>Glycerone phosphate hemimagnesium salt hydrate is a substrate molecule that is used in the control analysis of dihydroxyacetone phosphate. Glycerone phosphate hemimagnesium salt hydrate is an optimum concentration for 3T3-L1 preadipocytes and has been shown to have an effect on energy metabolism. Glycerone phosphate hemimagnesium salt hydrate also has enzymatic activity, which can lead to neuronal death or skin cancer. This compound is a monosodium salt that can be found in cytosolic calcium, which is present in cells and helps regulate muscle contraction. Glycerone phosphate hemimagnesium salt hydrate can also be found in basic proteins that are vital for cell function.</p>

This is a glycosylation product of 1,2,3-Tri-O-acetyl-4,6-O-benzylidene-b-D-glucopyranose with methyl and acetate groups. It is a synthetic oligosaccharide that has been fluorinated at the 4' position to provide protection from degradation. This product is custom synthesized for customers. It contains saccharides that are related to polysaccharides and complex carbohydrates. The compound is of high purity and does not contain any impurities. Click modification of the glucose moiety provides protection against enzymatic degradation by enzymes such as aminoglycoside N′ acetyltransferase.

<p>α 1,4-glucoheptasaccharide derived from starch by hydrolysis and chromatography</p>

2-Imino-2-methoxyethyl-1-deoxy-1-thio-a-D-mannopyranoside is a carbohydrate that belongs to the group of sugar. It can be custom synthesized and is available in high purity. This compound has been fluorinated and methylated, which means it has been modified with fluorine and methyl groups respectively. Click modification refers to a type of chemical modification to a molecule that occurs through the addition of a thiol group at the alpha carbon of an alcohol or amine group. 2-Imino-2-methoxyethyl-1-deoxy-1-thio-a-Dmannopyranoside can be glycosylated, which means it is able to undergo the process of glycosylation by transferring its saccharide unit onto another saccharide.

<p>Propargyl 2,3,4,6-tetra-O-acetyl-a-D-galactopyranoside is a modification of the carbohydrate that is a complex carbohydrate. It is a synthetic oligosaccharide with glycosylation and methylation. This compound has been found to have many potential applications in medicine and biotechnology. The fluorination of this saccharide may be used to create an antiangiogenic drug for cancer treatment.</p>

<p>2-Acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-D-gluconhydroximo-1,5-lactone is a custom synthesis. It is a modification of natural sugars. It has fluorination and methylation to make the product more stable. The product is an oligosaccharide that is a saccharide with two monosaccharides attached together. It is made up of complex carbohydrates.</p>

<p>a-L-Fucose-1-phosphate is a Glycosylation, complex carbohydrate, Methylation, Click modification, Polysaccharide, Fluorination, saccharide, Modification, sugar, Oligosaccharide and Synthetic product. a-L-Fucose-1-phosphate is available for custom synthesis and can be ordered with high purity.</p>

Tetra-O-acetyl-3-O-benzyl-a-D-mannopyranose is a modification of mannose. It is a complex carbohydrate that belongs to the class of oligosaccharides and has CAS No. 65827-58-9. The molecular weight of this compound is 462.76 g/mol. Tetra-O-acetyl-3-O-benzyl mannopyranose is synthesized for use as an analytical reagent to study the glycosylation and methylation reactions in carbohydrates, as well as for use in diagnostic kits for the detection of penicillinase and erythromycin resistance genes. This product has high purity, custom synthesis, and can be used as a monosaccharide or polysaccharide sugar in glycosylation reactions. Tetra O acetyl 3 O benzyl mannopyranose can also be fluorinated

<p>Ethyl D-thioglucuronide is a modification of an oligosaccharide, carbohydrate, complex carbohydrate or sugar. It can be synthesized by custom synthesis or by synthetic methods. The product is highly pure and monosaccharide methylated. The product can be glycosylated, polysaccharide, sugar fluorinated and saccharides click modified.</p>

<p>1-Deoxy-1-nitro-L-galactitol is a compound that has been shown to inhibit serine protease and glutaminyl cyclase activity. It is commonly used in laboratory settings as a potassium substitute in media formulations. This compound belongs to the class of monosaccharides known as glutaminyl derivatives. It has been studied for its potential as an inhibitor of nafamostat, a serine protease inhibitor used in the treatment of pancreatitis and disseminated intravascular coagulation (DIC). Additionally, 1-Deoxy-1-nitro-L-galactitol has been investigated for its potential as a disinfectant and as an adrenergic receptor agonist. Preliminary studies have also suggested antiviral properties against certain viruses. Further research is needed to fully understand the potential applications of this compound.</p>

<p>The characteristic structure of pectin is a linear chain of α-(1,4)-linked D-galacturonic acid that forms the pectin-backbone, a homogalacturonan (pectic acid). The polygalacturonic acid is partly esterified with methyl groups and the free acid groups may be partly or fully neutralized with sodium, potassium or ammonium ions. The ratio of esterified galacturonic acid groups to total galacturonic acid groups - termed the degree of esterification (DE) - has vital influence on the properties of pectin, especially the solubility and the gel forming characteristics. The mechanism for gel formation with calcium ions is known as ‘The egg box’. Into this backbone, there are regions where galacturonic acid is replaced by (1,2)-linked L-rhamnose. From the rhamnose residues, sidechains of various neutral sugars branch off. This type of pectin is called rhamnogalacturonan-I (RG-I). Up to every 25th galacturonic acid in the main chain is replaced with rhamnose. Some stretches consist of alternating galacturonic acid and rhamnose – “hairy regions”, others with lower density of rhamnose – “smooth regions”. The neutral sugars are mainly D-galactose, L-arabinose and D-xylose, the types and proportions of neutral sugars varying with the origin of pectin. Another structural type of pectin is rhamnogalacturonan II (RG-II), which is a less frequent complex, highly branched polysaccharide.</p>

<p>4-Methoxyphenyl 2,3,6-tri-O-acetyl-4-O-[2,4,6-tri-O-acetyl-3-O-(3,4,6-tri-O-acetyl-2-deoxy-2 -phthalimido)-bDglucopyranosyl]-bDgalactopyranoside is a high purity methylated glycoside of 4 methoxyphenol. The product has been modified by fluorination and Click chemistry to produce a complex carbohydrate. This modification can be used for the synthesis of oligosaccharides and polysaccharides.</p>

<p>Quinovic acid 3-O-b-D-glucoside is a fluorinated saccharide that has been synthesized in the laboratory. It is a high purity, synthetic sugar with an M+1 ion at m/z 571. The structure of this compound is O-α-D-mannopyranosyl-(1→2)-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl-(1→2)-O-.</p>

6-O-(a-D-Maltotriosyl)-D-glucopyranose tetradecaacetate is a carbohydrate that belongs to the class of saccharides. It is synthesized from D-glucose by glycosylation and methylation. 6-O-(a-D-Maltotriosyl)-D-glucopyranose tetradecaacetate is a complex carbohydrate with a high purity and custom synthesis. It can be used in click chemistry, due to its reactive group on the C6 position.

<p>Gala1-3(Fuca1-2)Galb1-4GlcNAcb1-3Gal (B antigen pentasaccharide Type II)</p>

2-Acetamido-6-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-3-O-(β-D-galactopyranosyl)-2,6-dideoxy--a,D--galactopyranose is a trisaccharide that is anomeric with n acetylglucosamine and a residue.

<p>Allyl 2-acetamido-4,6,-O-benzylidene-2-deoxy-a-D-glucopyranoside is a sugar that is used as a custom synthesis or modification. It is also called allyl 2-(1,3-dioxo-1,3,4,-thiadiazolidinium)acetamido 4,6,-O-(benzylidene)-2 deoxy erythro -a D glucopyranoside. Allyl 2 acetamido 4,6,-O -benzylidene -2 deoxy erythro -a D glucopyranoside is used in the glycosylation of proteins and oligosaccharides and in the synthesis of saccharides. This compound has been shown to be useful in identifying glycosaminoglycan chains in complex carbohydrates.</p>

<p>Benzyl 2-acetamido-3,4-di-O-acetyl-2-deoxy-6-O-DMT-a-D-galactopyranoside is a custom synthesis that is available in high purity. This product can be used for methylation, click modification, and fluorination. It is an oligosaccharide with a saccharide or carbohydrate as the main component. The molecular weight of this product is about 567.9 Da and the CAS number of this product is 103487-13-0.</p>

<p>Benzyl 2-acetamido-2-deoxy-4,6-O-benzylidene-3-O-(2,3,4,6-tetra-O-acetyl-b-D-galactopyranosyl)-a-D galactopyranoside is a complex carbohydrate with a CAS number of 8632784. It is an oligosaccharide that is modified with methylation and glycosylation. This molecule has a molecular weight of 907.19 and the purity level is high at 99%. This product can be used for fluoroquinolone resistance research or as an intermediate for other chemical modifications.</p>

<p>Hepta-O-acetyl-β-Lactosyl-N-Fmoc-L-serine is a methylated and saccharide modified polysaccharide that is synthesized by the click chemistry reaction. It has been used in the synthesis of complex carbohydrates, such as glycosides. Hepta-O-acetyl-β-Lactosyl-N-Fmoc-L-serine is an oligosaccharide with a molecular weight of 1,400 Da. The fluorination of this product helps to increase its purity. This product can be custom synthesized to meet your needs.</p>

R-Hydroxy topiramate is the stable isotope of the active pharmaceutical ingredient, topiramate. It can be used for the calibration of liquid chromatography and mass spectrometry methods. R-Hydroxy topiramate is prepared by dilution of a solution of topiramate with water, followed by elution from an ion exchange resin with methanol. The eluent is dried under vacuum to remove methanol and finally dissolved in a minimal volume of acetonitrile. R-Hydroxy topiramate is used to measure concentrations of lamotrigine and zonisamide in plasma and serum samples.

5-(S-2-Pyridin-3-yl-pyrrolidine)-1-yl-5-deoxy-1,2-isopropylidene-a-D-xylofuranose is a glycosylated sugar which can be modified with methyl groups, fluorine atoms, and saccharides. This compound has been synthesized in the laboratory and has not been found in nature. It is soluble in water and ethanol. The compound is available for custom synthesis to order.

<p>D-Ribopyranosyl thiosemicarbazide is a glycosylation agent that can be used in the synthesis of complex carbohydrates. It also has the ability to modify sugar structures, such as methylation, click modification, and fluorination. This reagent can be used for the modification of saccharides, oligosaccharides, and monosaccharides. D-Ribopyranosyl thiosemicarbazide is synthesized from d-ribose and thiosemicarbazide. The CAS number for this product is 95352-77-5.</p>

<p>2-Deoxy-scyllo-inosose is a biochemical with an unknown function. It is not a substrate for any known enzyme, but has been shown to be a substrate for the synthesis of corynebacterium glutamicum. The reaction mechanism of 2-deoxy-scyllo-inosose is still unclear, but it has been proposed that this molecule undergoes dehydration and then undergoes an acid catalyzed aldol cyclization to form 3-aminohexanol. This reaction produces fluorescence resonance energy transfer in group p2 subtilisin.<br>2DOS is also an antimicrobial agent which exhibits activity against Gram positive bacteria such as Streptococcus pyogenes, Enterococcus faecalis, and Bacillus subtilis.</p>

1-(2,3,5-Tri-O-acetyl-b-D-ribofuranosyl)-1,2,4-triazole-3-carboxylic acid methyl ester is a synthetic carbohydrate that has been modified with fluorine. It is an off white solid that has a molecular formula of C6H8O6 and a molecular weight of 252.1 g/mol. This compound is soluble in water and sparingly soluble in alcohol. 1-(2,3,5-Tri-O-acetyl-b-D-ribofuranosyl)-1,2,4-triazole-3-carboxylic acid methyl ester has been shown to possess antiviral activity against HIV as well as cytotoxicity to cancer cells.

Precursor of the uremic toxin indoxyl sulfate

Please enquire for more information about 4-Methylphenyl 4,6-o-benzylidene-2,3-di-o-(4-methoxybenzyl)-β-D-thiogalactopyranoside including the price, delivery time and more detailed product information at the technical inquiry form on this page

2,3,6,2',3',4',6'-Hepta-O-acetyl-b-D-lactosyl isothiocyanate is a fluorinated oligosaccharide that has been custom synthesized with a click modification. This compound is a high purity product and can be used in the synthesis of complex carbohydrates.

Polyphyllin A is a natural product that has been shown to have anti-oxidative effects. It has been demonstrated to inhibit the production of fatty acids by sephadex g-100, an enzyme activity by p. pastoris, and the production of antimicrobial peptides by tissue culture cells. Additionally, polyphyllin A has been shown to have anti-inflammatory properties and is used in traditional Chinese medicine for the treatment of cardiovascular diseases. Polyphyllin A also inhibits the oxidation of low density lipoprotein (LDL) cholesterol in coronary heart disease patients. Furthermore, polyphyllin A inhibits the proliferation of cancer cells such as leukemia HL-60 and K562 cells. The mechanism for this inhibition is not yet known but may be due to its ability to induce apoptosis or cause DNA damage.

<p>Alpha-cyclodextrin (α-CD) derivative with a hydrophilic exterior and lipophilic cavity (smaller than β-CDs and γ-CDs) to allocate certain guest molecules. This structural characteristic enables applications in molecular encapsulation, solubility enhancement, and stabilization across multiple industries. In pharmaceuticals, it serves as a drug delivery vehicle, enhancing the bioavailability and stability of active ingredients. The food industry utilizes it as a stabilizer for flavors, colors, and nutrients, as well as a functional ingredient for its effects on lipid metabolism. In cosmetics, it acts as a complex agent for fragrances and active components. Its applications extend to analytical chemistry for chiral separation and to materials science for developing smart materials and nanosystems.</p>

<p>Reductive amination of memantine with disaccharide.</p>

<p>3-O-(2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-D-glucopyranosyl)-1,2-di-O-benzyl-4,6-O-benzylidene--D--mannopyranoside is an oligosaccharide that has a high purity and custom synthesis. This compound is synthesized by Click modification of the sugar with fluorination. The glycosylation and methylation reactions are then carried out to obtain the final product. 3--0-(2--Acetamido--3,4,6--tri--O--acetyl--2--deoxy---D----glucopyranosyl)--1,2--di--O-----benzyl----4,6---O------benzylidene----D--------mannopyranoside is used in the synthesis of oligosaccharides for</p>

<p>4-Aminophenyl b-D-thioglucopyranoside is a compound that belongs to the group of small molecules and has been studied for its potential use as a drug to treat brain tumours. It has been shown that 4-Aminophenyl b-D-thioglucopyranoside binds to centromeric DNA sequences in mammalian cells, which can lead to inhibition of transcription and replication. This inhibitory effect on transcription and replication is due to the inhibition of acetyltransferase enzymes by 4-Aminophenyl b-D-thioglucopyranoside.</p>

<p>Cellulose acetate phthalate (CAP) finds use in the formulation of pharmaceuticals, such as the enteric coating of tablets or capsules and for controlled release formulations, where it is often used with other coating agents such as ethyl cellulose.  It contains about 50% acetate and 25% as the phthalate ester with the rest as free hydroxyl groups.  Enteric coatings based on CAP are resistant to acidic gastric fluids, but easily soluble in mildly basic medium of the intestine. The pH-sensitive solubility of CAP is mainly determined (as are other properties of this mixed ester) by the degree of substitution and by the molar ratio (acetyl and phthaloyl groups).</p>

<p>α-GalCer analog 8 is a high purity, custom synthesis, synthetic α-galactocerebrosidase enzyme that has been modified to include 8 fluorine atoms. The enzyme is glycosylated at the N-terminal and methylated at the C-terminal. The modification of this enzyme with an oligosaccharide and monosaccharide moiety improves its stability in vivo. α-GalCer analog 8 is used for the treatment of Gaucher's disease, which is caused by the accumulation of complex carbohydrates in the body. This condition can be managed using α-GalCer analog 8 because it hydrolyzes these complex carbohydrates into their monosaccharides.</p>

(S)-Ketoprofen metabolite.  Soluble in DMSO and methanol

<p>Nonyl b-D-thioglucopyranoside is a methylating agent that can be used in the synthesis of oligosaccharides and polysaccharides. This compound is a fluorinated sugar that is used as an intermediate in the synthesis of saccharide derivatives. Nonyl b-D-thioglucopyranoside is also a highly pure, stable chemical that has been modified to meet customer specifications. It can be used for the preparation of glycosyl fluorides, which are used to modify monosaccharides and other carbohydrates.</p>

2N-Fmoc-4N-(2,3,4,6-tetra-O-acetyl-b-D-glucopyranosyl)-L-aparagine is a modified carbohydrate that is used as a starting material for the synthesis of oligosaccharides and polysaccharides. It is synthesized by reacting 2N-Fmoc-L-serine with 4N-(2,3,4,6-tetraO-(acetyl)-bDglucopyranosyl)-Laparagine. The OAc group provides protection for the amino functions and can be removed in the presence of acid to yield an unprotected L(+)-serine. This product has high purity and can be purchased in various custom synthesis quantities.

<p>1,2-O-Di-O-acetyl-5-O-benzoyl-3-O-methyl -D-ribofuranose is a custom synthesis of a fluorinated sugar. It has been modified through fluorination at the C5 position and methylation at the O1 and O2 positions. This product can be used in the synthesis of oligosaccharides and saccharides that are glycosylated with sugars.</p>

5-(Acetylamino)-2-chloro-2,5-dideoxy-3-S-phenyl-3-thio-D-erythro-a-L-gluco-2,4,6-triulopyranosonic acid methyl ester 4,7,8,9 -tetraacetate is a synthetic compound that is modified with a fluorine atom. It is used as a reagent in the synthesis of oligosaccharides and polysaccharides. 5-(Acetylamino)-2,5 dideoxy 3S phenyl 3thio D erythro a L glucopyranosonic acid methyl ester 4 7 8 9 tetraacetate has the CAS number 120104 58 7. This compound can be synthesized from 2 chloro acetamide and 5 (acetylamino) 2 chloro 2 hydroxy pyridine. The molecular weight of this product is 5

<p>Hydroxyterbinafine b-D-glucuronide is a synthetic monosaccharide that has been modified by the addition of a fluorine atom. Hydroxyterbinafine b-D-glucuronide is an oligosaccharide or polysaccharide, which is composed of at least two saccharides. It is obtained from the hydrolysis of methylated hydroxyterbinafine. This compound has been shown to have antiviral, antifungal and anticancer activities.</p>

<p>3-Deoxy-3-fluoro-D-myo-inositol, also known as myo-inositol 3-O-(2'-deoxy) (dFMI), is a natural product found in the brain that has been shown to selectively inhibit the growth of trophozoites. It can bind to nonselective cations and block intracellular Ca2+ channels. This causes an increase in cytosolic Ca2+ concentration, which activates a cytosolic Ca2+ signal cascade. These effects show that dFMI is capable of inhibiting the growth of trophozoites by blocking the function of Ca2+ channels and increasing cytosolic Ca2+.</p>

<p>Trans-resveratrol 4'-O-b-D-glucuronide is a natural compound that is found in red wine and other foods. It has been shown to inhibit the growth of cancer cells through the activation of adenosine receptors, which are found on cancer cells and are responsible for apoptosis. Trans-resveratrol 4'-O-b-D-glucuronide has been shown to be an agonist of the adenosine a3 receptor, with high concentrations leading to apoptosis in human colon cancer cells. This compound also inhibits colon carcinogenesis by inhibiting cell proliferation and inducing apoptosis.</p>

<p>Galb1-3Galb1-4GlcNAcb1-3Galb1-4Glc is a complex carbohydrate that is synthesized from Galb1-4GlcNAcb1-3Galb1-4Glc and 3,6-anhydro-L-galactose. It has been modified with fluorination to prevent degradation. The synthesis of this product may be modified by methylation, glycosylation, or carbonylation. Galb1-3Galb1-4GlcNAcb1-3Galb1-4Glc has CAS No. 443660-52-4 and a purity of 96%. This product is stable at room temperature and may be used in the preparation of vaccines or diagnostic kits.</p>

<p>2-Deoxy-2-fluoro-L-[UL-13C]fucose is a modified sugar molecule used in various scientific applications, particularly in glycobiology and drug development.  It's used to study fucose-containing glycans, enzyme interactions, metabolic pathways, and glycoengineering. For instance, it can be incorporated into proteins to investigate the effects of fucose modifications on their function or used to develop drugs targeting fucose-metabolizing enzymes</p>

<p>4'-O-(b-D-2,3,4,6-Tetra-O-acetyl-glucopyranosyl)-4-nitrophloretin is a custom synthesis with Modification. This product was prepared by fluorination and methylation of 4'-O-(b-D-2,3,4,6-tetra-O-[1,2:1,3]triazolium chloride)-4' nitrophloretin. The molecular formula is C21H18N8O12 and molecular weight is 524.32. CAS No. 82628-87-3.</p>

<p>3,6-Di-O-benzoyl-D-galactal is a complex carbohydrate with CAS No. 130323-36-3 and a molecular weight of 538. It is an oligosaccharide that can be modified by methylation, glycosylation, or carbamylation. This product can also be fluorinated to form 3,6-di-O-(4'-fluoro)benzoyl-D-[2]galactal.</p>