Antiparasitics

Applications rac-Febrifugine dihydrochloride is the salt of Febrifugine, a bioactive constituent of a Chinese medicinal herb that is characterized by its therapeutic activity regarding malaria, cancer, fibrosis and inflammatory diseases.
References Keller, T.L.: Nat. Chem. Bio., 8, 311, (2012); Zhu, S. et al.: Bio. Med. Chem., 17, 4496 (2009);

Applications Monepantel is a recently discovered anthelmitic used in the treatment of parasitic nematodes via stun or kill without damaging the host entity.
References Baur, R. et al.: Mol. Pharm., 87, 96 (2015); Stuchlikova, L. et al.: Chemico. Biol. Interact., 227, 63 (2015);

Applications Aminorex is a metabolite of Levamisole (L331100). Aminorex is an anorectic stimulant drug of the 2-amino-5-aryl oxazoline class. Aminorex has been shown to have locomotor stimulant effects similar to Methamphetamine (M258795).
References Poos, G., et al.: J. Med. Chem., 6, 266 (1963), Watson, A., et al.: Res. Vet. Sci., 45, 411 (1988), Russell, B., et al.: Pharmacol. Biochem. Behav., 51, 375 (1995),

Stability Light Sensitive
Applications Aminorex and Rexamino as metabolites of Levamisole (L331100).
References Poos, G., et al.: J. Med. Chem., 6, 266(1963), Watson, A., et al.: Res. Vet. Sci., 45, 411 (1988), Russell, B., et al.: Pharmacol. Biochem. Behav., 51, 375 (1995),

Applications 4-Dechloro-4-hydroxy Diclazuril is an impurity of Diclazuril (D436200), a nucleotide analog with broad-spectrum anticoccidial activity.
References Fodey, T.L., et al.: J. Immunol. Meth., 323, 31 (2007);

Applications Diclazuril 6-Carboxamide is an impurity of Diclazuril (D436200), a nucleotide analog with broad-spectrum anticoccidial activity.

Applications Diclazuril 6-Carboxylic Acid [(4-Chlorophenyl)cyanomethyl]-2,6-dichlorophenyl-4-amide is an dimerized impurity of Diclazuril (D436200), a nucleotide analog with broad-spectrum anticoccidial activity.

Applications 4-Methoxy-6-(2-phenylethyl)-2H-pyran-2-one is a Kawain (K145490) derivative that is known to exhibit antimalarial and antituberculosis activities. 4-Methoxy-6-(2-phenylethyl)-2H-pyran-2-one has been identified as a lead compound for the dual treatment of malaria and leishmaniasis.
References McCracken, S.T., et al.: Bioorg. Med. Chem., 20, 1482 (2012); Elzaawely, A.A.. et al.: Food. Chem., 103, 486 (2007); Xuan, T.D., et al.: J. Natural. Med., 62, 188 (2008);

Applications Used in the antileishmanial activity of lipidic amino alcohols.
References Coimbra, E.: Chem. Biol. Drug Des. 75, 233 (2010).

Applications 2-Hydroxy-3-methylanthraquinone is a derivative of anthraquinone (A679245) which is an important precursor for many drugs, including Emodin (E523000), Aloe-emodin (A575400), Antimalarials such as Rufgallol, and also Antineoplastics used in the treatment of cancer, such as mitoxantrone (M373425), pixantrone (P552500), and the anthracyclines.
References Pan, X., et al.: Biochem. Eng. J., 5, 173 (2000), Macleod, L.C., et al.: Org. Synth., 14:4; (2005); McDonald, M., et al.: Drugs Exp. Clin. Res., 10, 745 (1984); Cavalletti, E. et al.: Invest. New Drugs, 25, 187 (2007);

Applications A diaminopyrimidine derivative with antimalarial and antibacterial properties.
References Coats, E. et al.: Eur. J. Med. Chem., 14, 261 (1979); Falco, E. et al.: Brit. J. Pharmacol. Chemoth., 6, 185 (1951)

Applications 2-Amino-N-(2-aminoethyl)benzamide hydrochloride is used in biological studies for immunization with recombinantly expressed glycan antigens from Schistosoma mansoni which induces glycan-specific antibodies against parasite.
References Prasanphanich, N. S., et al.: Glycobiology, 24, 619 (2014);

Applications 5-Bromo-1,2,3-trichlorobenzene is a useful intermediate in the preparation of isoxazole derivatives for controlling parasites, such as Rhipicephalus sanguineous nymphs.
References Gauvry, Noelle., et al.: PCT Int. Appl., WO 2012120135 A1 20120913. (2012);