Propofol and Impurities

<p>Applications Labelled Propofol (P829750). Propofol is an anesthetic used in veterinary medicine.<br>References Glen, J.B., and Hunter, S.C.: Brit. J. Anaesth., 56, 617 (1984), Kohnen, S.L., et al.: Nitric Oxide, 8, 170 (2003)<br></p>

<p>Impurity Propofol EP Impurity N<br>Applications Propofol 4-Carboxylic Acid (Propofol EP Impurity N) is a related compound of Propofol (P829750), as an antioxidant.<br>References Bahri, M., et al.: Biophys. Chem., 129, 82 (2007), Foti, M., et al.: J. Pharm. Pharmacol., 59, 1673 (2007), Gutierrez, M., et al.: Life Sci., 72, 2337 (2003),<br></p>

<p>Impurity Propofol EP Impurity J<br>Applications 2,6-Diisopropyl-1,4-benzoquinone (Propofol EP Impurity J) is a Propofol (P829750) impurity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References McMahon, R., et al.: J. Med. Chem., 22, 1100 (1979), Mamada, K., et al.: Drug Metab. Dispos., 14, 509 (1986),<br></p>

<p>Impurity Propofol EP Impurity O<br>Applications 2-Isopropyl-6-propylphenol (Propofol EP Impurity O).<br></p>

<p>Impurity Propofol EP Impurity E; Propofol USP Related Compound A<br>Applications Dipropofol (Propofol EP Impurity E) is a dimeric derivative of Propofol (P829750). Dipropofol is an antibacterial agent with strong activity againts Gram-positive bacteria. Dipropofol also displays antioxidant and radical scavenging activity. Propofol USP Related Compound A.<br>References Ogata, M. et al.: Chem. Pharm. Bull., 53, 344 (2005); Ogata, M. et al.: Biol. Pharmac. Bull., 30, 1565 (2007);<br></p>

<p>Impurity Propofol EP Impurity L<br>Applications 2,2-Dimethyl-4-isopropyl-1,3-benzodioxole (Propofol EP Impurity L).<br></p>

<p>Applications Propofol is an anesthetic used in veterinary medicine. Neuroprotective &amp; Neuroresearch Products<br>References Glen, J.B., and Hunter, S.C.: Brit. J. Anaesth., 56, 617 (1984), Kohnen, S.L., et al.: Nitric Oxide, 8, 170 (2003)<br></p>

<p>Applications Labelled Propofol β-D-Glucuronide (P829780). Propofol β-D-Glucuronide is a metabolite of Propofol (P829750), an anesthetic used in veterinary medicine.<br>References Fujiwara, R., et al.: Drug Metab. Dispos., 35, 747 (2007), Soars, M., et al.: J. Pharmacol. Toxicol. Methods, 47, 161 (2002),<br></p>

<p>Applications A metabolite of Propofol.<br>References Davies, M., et al.: Biochem. J., 257, 603 (1989), Eriksson, O., et al.: Biochem. Pharmacol., 44, 391 (1992), Bryson, H., et al.: Drugs, 50, 513, (1995), Raoof, A., et al.: Eur. J. Clin. Pharmacol., 50, 91 (1996)<br></p>

<p>Applications Propofol-d14 is the labeled analogue of Propofol (P829750), an anesthetic used in veterinary medicine.<br>References Glen, J.B., and Hunter, S.C.: Brit. J. Anaesth., 56, 617 (1984); Kohnen, S.L., et al.: Nitric Oxide, 8, 170 (2003)<br></p>

<p>Stability Hygroscopic<br>Applications Propofol β-D-Glucuronide is a metabolite of Propofol (P829750), an anesthetic used in veterinary medicine.<br>References Fujiwara, R., et al.: Drug Metab. Dispos., 35, 747 (2007), Soars, M., et al.: J. Pharmacol. Toxicol. Methods, 47, 161 (2002),<br></p>

<p>Impurity Propofol EP Impurity F<br>Stability Light Sensitive<br>Applications 3-Isopropylphenol (Propofol EP Impurity F) is an impurity of Propofol (P829750).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bahri, M., et al.: Biophys. Chem., 129, 82 (2007), Foti, M., et al.: J. Pharm. Pharmacol., 59, 1673 (2007), Vasileiou, I., et al.: Eur. J. Pharmacol., 605, 1 (2009),<br></p>

<p>Impurity Propofol EP Impurity G; Propofol USP Related Compound C<br>Applications Propofol Isopropyl Ether (Propofol EP Impurity G; Propofol USP Related Compound C) is an isopropyl ether derivative of the anesthetic Propofol (P829750).<br></p>

<p>Impurity Propofol EP Impurity H<br>Applications 4-Isopropylphenol (Propofol EP Impurity H) is an impurity of Propofol (P829750).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bahri, M., et al.: Biophys. Chem., 129, 82 (2007), Foti, M., et al.: J. Pharm. Pharmacol., 59, 1673 (2007), Vasileiou, I., et al.: Eur. J. Pharmacol., 605, 1 (2009),<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Propofol. Anesthetic (intravenous).<br>References Davies, M., et al.: Biochem. J., 257, 603 (1989), Eriksson, O., et al.: Biochem. Pharmacol., 44, 391 (1992), Bryson, H., et al.: Drugs, 50, 513, (1995), Raoof, A., et al.: Eur. J. Clin. Pharmacol., 50, 91 (1996)<br></p>

<p>Applications 3,5-Di-tert-butyl-4-hydroxyphenylpropionic Acid acts as a new oxazole-pyrone antimicrobial agent. Inhibits electron transport in complex 1 of the respiratory chain. HIV-1 inihibitor.<br>References Kunze, B. et al.: J. Antibiot., 45, 1549 (1992); Yashuharu, I. et al.: Tetrahedron Lett., 37, 2997 (1996);<br></p>

<p>Impurity Propofol EP Impurity B<br>Applications 2-Isopropenyl-6-isopropylphenol (Propofol EP Impurity B) is an alkylphenol derivative with anesthetic activity.<br>References James, R. et al.: J. Med. Chem., 23, 1350 (1980);<br></p>

<p>Applications Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate is an antioxidant that is used in polyethylene.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Blazquez-Blazquez, Enrique. et al., ACS Omega. 16, 9055-9063(2020);<br></p>

<p>2-Isopropyl-6-propylphenol is a reactive alkylating agent that reacts with proteins and enzymes. It binds to the hydroxyl group of a protein target, which modifies the activity of the target molecule by introducing a new functional group. 2-Isopropyl-6-propylphenol has been shown to bind to the active site of several enzymes, including human serum albumin and cytochrome P450 reductase. The binding constants for these targets have been determined computationally using an algorithm based on quantum chemical calculations. These values are in good agreement with experimental data obtained from titration calorimetry experiments at different temperatures.</p>

<p>Applications Labelled Propofol β-D-Glucuronide methyl ester (P829810). Propofol β-D-Glucuronide methyl ester is a precursor to metabolite Propofol β-D-Glucuronide (P829780).<br></p>

<p>Impurity Propofol EP Impurity C<br>Applications 2-Isopropylphenol (Propofol EP Impurity C) is an impurity of Propofol (P829750).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bahri, M., et al.: Biophys. Chem., 129, 82 (2007), Foti, M., et al.: J. Pharm. Pharmacol., 59, 1673 (2007), Vasileiou, I., et al.: Eur. J. Pharmacol., 605, 1 (2009),<br></p>

<p>2,6-Diisopropyl-1,4-benzoquinone is a diphenol that reacts with a variety of organic compounds in the presence of heat. It has been used as a mesoporous material to adsorb hydrogen gas and carbon dioxide in the water treatment process. 2,6-Diisopropyl-1,4-benzoquinone is also able to react with oxygen to form an n-oxide. This compound is most often used for the manufacture of phenolic antioxidants such as dibenzoyl peroxide and pentafluorobenzoic acid. The active site on this molecule is thought to be at the double bond between carbons 6 and 7. Impurities may include anisidine and other aromatic amines that can cause reactions with hydrogen peroxide when exposed to light or certain wavelengths of radiation.</p>