Propofol and Impurities

<p>Applications Labelled Propofol (P829750). Propofol is an anesthetic used in veterinary medicine.<br>References Glen, J.B., and Hunter, S.C.: Brit. J. Anaesth., 56, 617 (1984), Kohnen, S.L., et al.: Nitric Oxide, 8, 170 (2003)<br></p>

<p>Impurity Propofol EP Impurity N<br>Applications Propofol 4-Carboxylic Acid (Propofol EP Impurity N) is a related compound of Propofol (P829750), as an antioxidant.<br>References Bahri, M., et al.: Biophys. Chem., 129, 82 (2007), Foti, M., et al.: J. Pharm. Pharmacol., 59, 1673 (2007), Gutierrez, M., et al.: Life Sci., 72, 2337 (2003),<br></p>

<p>Impurity Propofol EP Impurity J<br>Applications 2,6-Diisopropyl-1,4-benzoquinone (Propofol EP Impurity J) is a Propofol (P829750) impurity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References McMahon, R., et al.: J. Med. Chem., 22, 1100 (1979), Mamada, K., et al.: Drug Metab. Dispos., 14, 509 (1986),<br></p>

<p>Impurity Propofol EP Impurity O<br>Applications 2-Isopropyl-6-propylphenol (Propofol EP Impurity O).<br></p>

<p>Impurity Propofol EP Impurity E; Propofol USP Related Compound A<br>Applications Dipropofol (Propofol EP Impurity E) is a dimeric derivative of Propofol (P829750). Dipropofol is an antibacterial agent with strong activity againts Gram-positive bacteria. Dipropofol also displays antioxidant and radical scavenging activity. Propofol USP Related Compound A.<br>References Ogata, M. et al.: Chem. Pharm. Bull., 53, 344 (2005); Ogata, M. et al.: Biol. Pharmac. Bull., 30, 1565 (2007);<br></p>

<p>Impurity Propofol EP Impurity L<br>Applications 2,2-Dimethyl-4-isopropyl-1,3-benzodioxole (Propofol EP Impurity L).<br></p>

<p>Applications Propofol is an anesthetic used in veterinary medicine. Neuroprotective &amp; Neuroresearch Products<br>References Glen, J.B., and Hunter, S.C.: Brit. J. Anaesth., 56, 617 (1984), Kohnen, S.L., et al.: Nitric Oxide, 8, 170 (2003)<br></p>

<p>Applications Labelled Propofol β-D-Glucuronide (P829780). Propofol β-D-Glucuronide is a metabolite of Propofol (P829750), an anesthetic used in veterinary medicine.<br>References Fujiwara, R., et al.: Drug Metab. Dispos., 35, 747 (2007), Soars, M., et al.: J. Pharmacol. Toxicol. Methods, 47, 161 (2002),<br></p>

<p>Applications A metabolite of Propofol.<br>References Davies, M., et al.: Biochem. J., 257, 603 (1989), Eriksson, O., et al.: Biochem. Pharmacol., 44, 391 (1992), Bryson, H., et al.: Drugs, 50, 513, (1995), Raoof, A., et al.: Eur. J. Clin. Pharmacol., 50, 91 (1996)<br></p>

<p>Applications Propofol-d14 is the labeled analogue of Propofol (P829750), an anesthetic used in veterinary medicine.<br>References Glen, J.B., and Hunter, S.C.: Brit. J. Anaesth., 56, 617 (1984); Kohnen, S.L., et al.: Nitric Oxide, 8, 170 (2003)<br></p>

<p>Stability Hygroscopic<br>Applications Propofol β-D-Glucuronide is a metabolite of Propofol (P829750), an anesthetic used in veterinary medicine.<br>References Fujiwara, R., et al.: Drug Metab. Dispos., 35, 747 (2007), Soars, M., et al.: J. Pharmacol. Toxicol. Methods, 47, 161 (2002),<br></p>

<p>Impurity Propofol EP Impurity F<br>Stability Light Sensitive<br>Applications 3-Isopropylphenol (Propofol EP Impurity F) is an impurity of Propofol (P829750).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bahri, M., et al.: Biophys. Chem., 129, 82 (2007), Foti, M., et al.: J. Pharm. Pharmacol., 59, 1673 (2007), Vasileiou, I., et al.: Eur. J. Pharmacol., 605, 1 (2009),<br></p>

<p>Impurity Propofol EP Impurity G; Propofol USP Related Compound C<br>Applications Propofol Isopropyl Ether (Propofol EP Impurity G; Propofol USP Related Compound C) is an isopropyl ether derivative of the anesthetic Propofol (P829750).<br></p>

<p>Impurity Propofol EP Impurity H<br>Applications 4-Isopropylphenol (Propofol EP Impurity H) is an impurity of Propofol (P829750).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bahri, M., et al.: Biophys. Chem., 129, 82 (2007), Foti, M., et al.: J. Pharm. Pharmacol., 59, 1673 (2007), Vasileiou, I., et al.: Eur. J. Pharmacol., 605, 1 (2009),<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Propofol. Anesthetic (intravenous).<br>References Davies, M., et al.: Biochem. J., 257, 603 (1989), Eriksson, O., et al.: Biochem. Pharmacol., 44, 391 (1992), Bryson, H., et al.: Drugs, 50, 513, (1995), Raoof, A., et al.: Eur. J. Clin. Pharmacol., 50, 91 (1996)<br></p>

<p>Applications 3,5-Di-tert-butyl-4-hydroxyphenylpropionic Acid acts as a new oxazole-pyrone antimicrobial agent. Inhibits electron transport in complex 1 of the respiratory chain. HIV-1 inihibitor.<br>References Kunze, B. et al.: J. Antibiot., 45, 1549 (1992); Yashuharu, I. et al.: Tetrahedron Lett., 37, 2997 (1996);<br></p>

<p>Impurity Propofol EP Impurity B<br>Applications 2-Isopropenyl-6-isopropylphenol (Propofol EP Impurity B) is an alkylphenol derivative with anesthetic activity.<br>References James, R. et al.: J. Med. Chem., 23, 1350 (1980);<br></p>

<p>Applications Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate is an antioxidant that is used in polyethylene.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Blazquez-Blazquez, Enrique. et al., ACS Omega. 16, 9055-9063(2020);<br></p>