Cinnamic Acids

<p>3-Methoxycinnamic acid is a hydroxycinnamic acid that has been shown to inhibit the migration of polymorphonuclear cells and leukocytes. It also inhibits chemotaxis by blocking the production of intracellular cyclic AMP (cAMP) in these cells. 3-Methoxycinnamic acid has been shown to have an inhibitory effect on the production of cAMP in leukocytes and polymorphonuclear cells, as well as inhibiting chemotaxis. The compound is also known to be a potent antioxidant due to its ability to scavenge reactive oxygen species (ROS).</p>

<p>4-Phenylcinnamic acid is a prenylated aromatic compound that is used as a chromatographic stationary phase. It has been shown to inhibit the activity of tyrosinase and thus may be used for the treatment of hyperpigmentation disorders such as melasma. 4-Phenylcinnamic acid interacts with piperidine and inhibits its activity, which may lead to new drug development. Molecular modelling of 4-phenylcinnamic acid has shown that it is possible to introduce functional groups into the molecule, making it more reactive. The introduction of biphenyl derivatives may improve the lipophilicity of this molecule.</p>