Cannabinoids

HU-308, a synthetic cannabinoid analogue, is a highly selective agonist of the CB2 receptor. It demonstrates an affinity for the CB2 receptor that is over 440 times greater than its affinity for the CB1 receptor, which are predominantly found in immune cells. This compound plays a crucial role in modulating the immunosuppressive effects of the endocannabinoid system (ECS). Additionally, HU-308 possesses anti-inflammatory and neuroprotective properties, and it regulates the function of microglia. Its potential applications include research into neuroinflammation and retinal diseases.

CB1R antagonist 2 (Compound 11g) functions as an antagonist of the cannabinoid receptor 1 (CB1R), inhibiting the MAPK/NF-κB signaling pathway and exhibiting anti-inflammatory properties. In RAW264.7 cells, it suppresses LPS-induced expression of IL-6, IL-1β, and TNF-α. In murine models, it improves OVA-induced allergic rhinitis.

TRPM8 antagonist 4 prodrug (Compound 8b) is an orally active CB2R agonist (EC50: 51.2 nM) and a weak TRPM8 antagonist. It acts as a prodrug of TRPM8 antagonist 4, exhibiting anti-inflammatory and analgesic properties. TRPM8 antagonist 4 prodrug is applicable in studies of inflammation-related pain disorders.

Compound 39, also known as CB2 receptor antagonist 2, is a potent CB2 antagonist exhibiting an IC50 of 0.33 μM.

N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide: binds CB1 (Ki=365 nM), activates PPARα (EC50=698 nM), reduces rat food intake, no FAAH inhibition.

N-terminally extended form of human hemopressin that acts as a selective CB1 receptor agonist.

Peptide inhibitor for ep24.15, neurolysin & ACE with Ki 27.76, 3.43, 1.87 μM. Lowers blood pressure, modulates CB1 receptor, reduces pain & food intake.

2-Arachidonoylglycerol-D5 is the deuterated form of 2-Arachidonoylglycerol (T14011), which acts as an endogenous cannabinoid ligand within the central nervous system.

TRPV1/CB2 agonist 1 (compound 41) is a dual agonist targeting hTRPV1 and CB2 receptors, with an EC50 value of 26.8 μM for hTRPV1. It is applicable in research related to the nervous system.

SCOTfluor-89 is a small, conjugatable, orthogonal, and multicolor fluorescent group designed for in vivo imaging of cell metabolism.

Nervonoyl ethanolamide (NEA), an endogenous cannabinoid, functions as both a presynaptic and postsynaptic neuromodulator. Additionally, it is utilized in inflammation research [1].

CB2R Probe 1, a cannabinoid 2 receptor (CB2R) fluorescent probe, exhibits both safety and environmental friendliness, boasting a dissociation constant (K i) of

UVI3502 is a cannabinoid receptor 1 (CB1) antagonist with an IC50 value of 4641 nM for CB1 and approximately 16200 nM for CB2. It can inhibit Gi/o protein coupling induced by the agonist CP55,940. UVI3502 shows potential for research into diseases related to the endocannabinoid system in the central nervous system, such as cognitive impairments and neurodegenerative disorders.

Docosahexaenoyl glycerol, an analog of endocannabinoid, stimulates glucose uptake and exhibits anti-inflammatory efficacy [1] [2].

Endogenous peptide, inhibits ep24.15/24.16/ACE with Ki of 27.76/3.43/1.87 μM. Lowers blood pressure, CB1 inverse agonist, reduces pain in vivo.

(R)-Zevaquenabant ((R)-MRI-1867) is the enantiomer of Zevaquenabant. Zevaquenabant ((S)-MRI-1867) is a peripherally restricted, orally bioavailable dual antagonist of the cannabinoid CB1 receptor and inducible nitric oxide synthase (iNOS). It is beneficial in improving chronic kidney disease (CKD) caused by obesity.

CB2R/FAAH modulator-1: agonizes CB2R, inhibits FAAH (IC50=4 μM), alters cytokine production; used in inflammation research. Ki: CB2R=14.8 nM, CB1R=241.3 nM.

Zevaquenabant (S-MRI-1867): oral CB1/iNOS antagonist combatting obesity-induced CKD.

(±)5(6)-EET Ethanolamide is a metabolite derived from Anandamide through oxidation by cytochrome P450 enzymes. It acts as a selective cannabinoid receptor 2 (CB2) agonist. The Ki values for (±)5(6)-EET Ethanolamide against human CB1 and CB2 are 11.4 μM and 8.9 nM, respectively. This compound can be used in studies related to immunoregulation and neuroinflammation.

Fluorescent form of AM 251, CB1 receptor antagonist