Hormones

<p>Applications Testosterone-2,2,4,6,6-d5 Benzoate is a useful isotopically labeled compound of Testosterone Benzoate (T155015)<br></p>

<p>Applications Testosterone-2,2,4,6,6-d5 Propionate is a useful isotopically labeled compound of Testosterone Propionate (T155045)<br></p>

<p>Applications Testosterone-16,16,17-d3 17-Phenylpropionate, is the labeled analogue of Testosterone 17-Phenylpropionate (T155150), a Testosterone ester being misused by athletes in an attempt to improve sports performance. It can also be used as a therapy in glucocorticoid-treated patients to increase the circulating testosterone concentration.<br>References Shackleton, C. H. L., et al.: Steroids, 62 (7), 523 (1997); Reid, I. R., et al.: Archives Internal Med., 156 (11), 1173 (1996);<br></p>

<p>Stability Acid Sensitive<br>Applications 17β-(Trimethylsiloxy)testosterone is an anabolic steriod, and a derivative compound of Testosterone (T155000), Principal hormone of the testes, produced by the interstitial cells. Major circulating androgen; converted by 5α-reductase in androgen-dependent target tissues to 5α-dehydrotestosterone which is required for normal male sexual differentiation. Also converted by aromatization to Estradiol.Testerone is a controlled substance (anabolic steroid). Androgen.<br>References McFarland, K., et al.: Science, 245, 494 (1989), Heckert, L., et al.: Mol. Endocrinol., 12, 1499 (1998), Themmen, A., et al.: Endocr. Rev. 21, 551 (2000), Kumar, R., et al.: Biol. Reprod., 65, 710 (2001),<br></p>

<p>Applications Testosterone Heptanoate-6,6,7,7,7-d5 (CAS# 1263095-31-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Androsten-17alpha-methyl-17beta-ol-3-one-1,2-d2 is a useful isotopically labeled compound of 17α-Methyl Testosterone (M326400)<br></p>

<p>Applications Dydrogesterone (D826000) intermediate. Used in the preparation of 10α-steroids.<br></p>

<p>Follicle Stimulating Hormone (FSH) is a protein hormone that plays a crucial role in the reproductive cycle. It stimulates the growth and development of follicles in the ovaries, which produce estrogen and progesterone. FSH also regulates spermatogenesis in men. Studies have shown that FSH has inhibitory activity on cyclin-dependent kinases, which are enzymes that regulate the cell cycle. This inhibitory activity leads to decreased cell proliferation and growth, making it a potential treatment for cancer. In vitro studies have demonstrated its effectiveness against breast and lung cancer cells lines when combined with kinase inhibitors. Additionally, FSH has been found to stimulate protein kinase activity, which may be useful in developing therapies for other diseases such as diabetes and osteoporosis.</p>

<p>Insulin Porcine is a two chain, glycosylated polypeptide chain containing 51 amino acids and having a molecular mass of 5777 Dalton.  The a and b chains are joined by two interchain disulfide bonds with the a chain containing an intrachain disulfide bond. Insulin regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat.</p>

<p>Erythropoietin is a hormone that stimulates the production of red blood cells, and is used for patients with anemia. It is a recombinant human erythropoietin (rhEPO) that has been produced by genetic engineering. Erythropoietin binds to receptors on the surface of many types of cells, including those in the bone marrow. This binding stimulates the production of red blood cells from precursor cells in the bone marrow, and increases oxygen-carrying capacity in blood. The half-life of erythropoietin is approximately 36 hours. This drug also can be used to reduce high blood pressure and improve responsiveness to other drugs that are given intravenously. Erythropoietin can cause an increase in asialoglycoprotein levels in serum, which may be due to its effects on hepatocytes or erythrocytes.</p>