Nucleosides

<p>Guanosine-5'-[(b,gamma)-methyleno]triphosphate sodium salt (GMPP) is an analog of guanosine triphosphate that is enzymatically inactivated by the enzyme kinesin. GMPP inhibits the polymerization of microtubules by binding to the kinesin molecule and preventing it from binding to tubulin. GMPP has been shown to inhibit sephadex g-100 chromatography and act as a competitive inhibitor for protein synthesis in vitro. GMPP has also been shown to have a fat cell differentiation effect which may be due to its ability to inhibit microtubule polymerization.</p>

<p>2,3'-Anhydro-N4-benzoyl-2'-deoxycytidine 5'-CE phosphoramidite is a novel nucleoside analog that has been synthesized to have the same chemistry as 2,3'-dideoxycytidine 5'-C phosphoramidite. It has antiviral and anticancer properties. This compound can be used in the synthesis of oligonucleotides for DNA sequencing and for gene therapy.<br>2,3'-Anhydro-N4-benzoyl-2'-deoxycytidine 5'-CE phosphoramidite is not toxic to normal cells, but it inhibits replication of viruses such as HIV and herpes simplex virus.</p>

<p>N6-Dimethyl-3’-b-C-methyladenosine is a novel nucleoside analog that has antiviral and anticancer properties. It is a phosphoramidite, which can be used as an activator for the synthesis of modified oligonucleotides. N6-Dimethyl-3’-b-C-methyladenosine has been shown to activate ribonucleosides and deoxyribonucleosides in vitro. This compound also has anticancer properties, which may be due to its ability to act as an activator in the synthesis of DNA.</p>

<p>Please enquire for more information about 1'-13CCytidine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>N2-Phenylacetyl-L-guanosine is a nucleoside that has been synthetically modified to have the desired properties of an anticancer agent. This compound inhibits DNA synthesis and is therefore cytotoxic to cells. It also inhibits RNA synthesis and is antiviral. N2-Phenylacetyl-L-guanosine has been found to be effective in preventing the growth of leukemia cells, breast cancer cells, prostate cancer cells, and ovarian cancer cells. N2-Phenylacetyl-L-guanosine is a nucleotide analogue that can be used as a building block for DNA or RNA synthesis. It can be used as a phosphate donor in phosphoramidite chemistry and can activate other nucleosides for use in chemical biology.</p>

<p>2',3'-Dideoxy-5-iodouridine is a synthetic nucleoside analog derived from uridine, one of the natural building blocks of RNA. This molecule has been chemically modified to disrupt the normal processes of DNA and RNA synthesis, making it a candidate for antiviral and anticancer research.</p>

<p>N4-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-MMT-cytidine 3'-CE phosphoramidite is a novel nucleoside analog that has been synthesized by the incorporation of a methyl group at the 5′ position. This modification results in an increased cytotoxicity and cellular uptake in cancer cells. N4-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-MMT-cytidine 3'-CE phosphoramidite also inhibits the replication of HIV and herpes simplex virus type 1 (HSV1) and type 2 (HSV2), which are responsible for AIDS and genital herpes, respectively.<br>N4 - Benzoyl - 2 ' - O - tert - butyldimethylsilyl - 5 ' - O - MMT - cytidine 3' CE phosphoram</p>

<p>2'-O-Methyl-5-propynyluridine is a nucleoside that is selective to bacterial DNA. It has been shown to inhibit the binding of RNA polymerase and DNA gyrase, as well as the synthesis of RNA and DNA. This nucleoside also inhibits the formation of triplexes in vitro with oligonucleotides complementary to sequences in the 16S ribosomal RNA gene. 2'-O-Methyl-5-propynyluridine has been used for the measurement of RNA polymerase activity in bacteria, and its affinity for triplexes can be measured by gel shift assay.</p>

<p>2'-O-Methylcytidine is a nucleoside with a hydroxyl group on the 2' carbon. The hydroxyl group makes it an effective inhibitor of viral replication, and it has been shown to be active against HIV-1 in cell culture. 2'-O-Methylcytidine is also metabolized by nucleotide salvage pathways, and the metabolic response can be studied using proton nuclear magnetic resonance (NMR) spectroscopy and x-ray diffraction data. It has been found that 2'-O-Methylcytidine inhibits protein synthesis in cancer cells, and this may be due to its ability to bind to the response element on DNA.</p>

<p>Thymidine, also known as deoxythymidine (dT), is a pyrimidine deoxynucleoside that pairs with deoxyadenosine (dA) in a double stranded DNA. It’s used as a biochemical modulator of antimetabolites such as 5-fluorouracil (5-FU), 1-beta-D-arabinofuranosylcytosine (Cytarabine) and methotrexate (MTX) in cancer therapy. It’s also the enantiomer of telbivudine, an antiviral drug used to treat hepatitis B virus (HBV) infection.</p>

<p>5'-O-DMT-2'-O-methylguanosine is a novel nucleoside analog that has been modified to contain the 2' methyl group at the 5' position. This modification enhances its anticancer activity and cellular uptake by cells. The 5'-O-DMT-2'-O-methylguanosine monophosphate synthesized in this study is chemically stable, high purity, and high quality.</p>

<p>Sold by weight of nucleoside as solution in ethanol.</p>

<p>3'-Amino-3'-deoxy-5'-O-trityl-D3-thymidine is a nucleoside and deoxyribonucleoside. It is an antiviral and anticancer agent that inhibits the synthesis of DNA by competitively inhibiting the enzyme ribonucleotide reductase, which converts ribonucleotides to deoxyribonucleotides. 3'-Amino-3'-deoxy-5'-O-trityl-D3-thymidine has been shown to be effective in treating HIV, herpes zoster, and cancer cells.</p>

<p>7-Deaza-2'-deoxy-7-iodoadenosine is an oligomer with a stabilized backbone that has been shown to inhibit the growth of bacteria in vitro. It binds to DNA and prevents RNA synthesis. 7-Deaza-2'-deoxy-7-iodoadenosine is a synthetic nucleotide analogue that is used as a probe for mapping RNA sequences and as an inhibitor of bacterial growth. This compound is also used in the synthesis of oligodeoxynucleotides because it has a high affinity for guanine residues, which can be incorporated into the oligonucleotide chain by chemical ligation. The octameric form of 7-deaza-2'-deoxyadenosine is most active against bacterial cells.</p>

<p>Inosine-3',5'-cyclic-monophosphate triethylammonium is a synthetic nucleoside that functions as an activator of the deoxyribonucleotide synthesis. It has antiviral and anticancer properties, and has been shown to have anti-inflammatory activities. Inosine-3',5'-cyclic-monophosphate triethylammonium has been shown to inhibit the growth of cells in culture and induce apoptosis. This is due to its ability to inhibit DNA synthesis by inhibiting the enzyme ribonucleotide reductase.</p>

<p>5’-O-DMT-3’-O-levulinyl-2’-deoxyadenosine is a monophosphate antiviral agent. It has been shown to inhibit the activity of DNA and RNA polymerases in vitro. The drug is novel, and its antiviral properties have not been tested in vivo. 5’-O-DMT-3’-O-levulinyl-2’-deoxyadenosine has been synthesized using phosphoramidites and was found to be of high quality and purity. It has also been modified at the 2' position with an acetyl group and at the 3' position with a levulinoyl group.</p>

<p>Coenzyme and regenerating electron donor in catabolic processes</p>

<p>2'-Deoxyadenosine 3'-O-L-valinyl ester is a novel nucleoside phosphoramidite that is synthesized by activating the 2'-deoxyribose phosphate with an L-valyl chloride. This synthetic nucleoside analog can be used as a substitute for dATP in DNA synthesis and has antiviral as well as anticancer activities.</p>

<p>Cytidine 5'-triphosphate (CTP) disodium dihydrate prevents the action of aspartate carbamoyltransferase, an enzyme involved in pyrimidine biosynthesis. CTP serves as a molecule of high energy and acts as a coenzyme in glycerophospholipid biosynthesis and protein glycosylation.</p>

<p>9-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)guanine is a nucleoside phosphorylase inhibitor that is used to treat inflammatory bowel disease. It has been shown to be effective in treating women with inflammatory bowel disease, and has no significant side effects. 9-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)guanine inhibits the bacterial enzyme nucleoside phosphorylase, which is responsible for the conversion of guanosine triphosphate (GTP) to guanosine diphosphate (GDP). This inhibition prevents the synthesis of DNA and RNA by blocking the conversion of GTP and GDP into AMP and GMP. The drug binds to the active site of nucleoside phosphorylase, which is located in the bacterial cytoplasmic membrane. 9-(2'-Deoxy-2'-fluoro</p>