Nucleosides

<p>2-Amino-4-(4-bromophenyl)pyrimidine is a phosphoramidite, modified nucleoside. It is an antiviral and anticancer agent that inhibits DNA synthesis. 2-Amino-4-(4-bromophenyl)pyrimidine is a novel nucleotide analog with the ability to inhibit replication of RNA and DNA in vitro. This compound has been shown to be active against herpes simplex virus type 1 (HSV1), cytomegalovirus (CMV), and HIV in cell culture. Furthermore, this phosphoramidite has been shown to have no detectable toxicity in mice at doses up to 2000 mg/kg.</p>

<p>4-Chloro-7-(2-C-methyl-b-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine is a novel anticancer compound that inhibits the synthesis of DNA, RNA and protein. It is a phosphoramidite monophosphate that can be used in the synthesis of oligonucleotides and DNA. 4CHP is effective against Herpes simplex virus type 1 (HSV1) and cytomegalovirus (CMV). 4CHP also has antiviral activity against influenza A virus.</p>

<p>4-Aminopyrimidine-5-carboxylic acid is an aminopyrimidone that has been synthesized to be used as a new class of antihypertensive agents. It has dose-dependent blood pressure lowering effects, which are likely due to its ability to block angiotensin receptors. 4-Aminopyrimidine-5-carboxylic acid also has antibacterial and antifungal properties. This compound is metabolized in vivo into the pharmacologically active amine 6-aminonicotinamide and excreted in the urine. In vitro studies have shown that 4-aminopyrimidine-5 carboxylic acid inhibits the growth of bacteria by binding to DNA gyrase and topoisomerase IV enzymes required for cell division.</p>

<p>3’-O-(2-Methoxyethyl)guanosine is a nucleoside analogue of guanosine. It is a modified, deoxyribonucleoside that is synthesized from 2-methoxyethanol and 1,2-dihydroxybenzene. 3’-O-(2-Methoxyethyl)guanosine has antiviral, anticancer, and DNA synthesis inhibitory activities. This nucleoside analogue increases the intracellular concentration of guanosine by inhibiting its degradation. 3’-O-(2-Methoxyethyl)guanosine has been used as an antiviral agent in the treatment of influenza A virus infection in humans and animals.</p>

<p>L-5-methyluridine is a nucleoside that is used as a building block in the synthesis of oligonucleotides. It contains one ribose sugar and one deoxyribose sugar, linked to the base adenine by a phosphate group. L-5-methyluridine can be synthesized from 5-chloro-2'-deoxyadenosine, hypoxanthine, and ammonium chloride. The synthesis starts with condensation reactions between the two sugar molecules to form an intermediate called a nucleoside. This is followed by alkylation of the base and then oxidation of the sugar group to form anomeric esters. The last step involves hydrolysis of the acyloxy ester, which yields L-5-methyluridine after acidification.</p>

<p>3-[2'-Deoxy-5'-O-DMT-b-D-ribofuranosyl]pyrido[2,3-d]pyrimidine-2,7(8H)-dione 3'-CE phosphoramidite is a synthetic compound that is a member of the class of brassinosteroids. It has been shown to activate the transcription factor NF-Y in vitro and in vivo. Brassinosteroids have been shown to have regulatory effects on plant tissue development, including normalization of cell growth, and are involved in the activation of cellulase activity. They also have been shown to increase the resistance of plants to environmental stresses such as drought.</p>

<p>4-Amino-2,6-dimethyl-8-(2'-deoxy-b-D-ribofuranosyl)-7-pteridone is a fluorescent probe that can be used to monitor nucleic acid synthesis. It is an analog of adenosine and interacts with the enzyme RNA polymerase in a process that is mediated by the adenosine receptor, which leads to termination of transcription. This compound has been shown to yield high fluorescence yields at room temperature and has minimal interaction with other monomers or dimers. 4-Amino-2,6-dimethyl-8-(2'-deoxy-b-D-ribofuranosyl)-7-pteridone can be used as a probe for monitoring DNA synthesis in vitro and in vivo.</p>

<p>Please enquire for more information about SPACER-C 12 CEP including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2',3'-Dideoxyguanosine-5'-triphosphate (ddGTP) is a nucleotide analog that inhibits the formation of DNA and RNA, which are important for protein synthesis. It is used in clinical studies to assess prognosis and to evaluate drug elimination. ddGTP has been shown to inhibit mitochondrial membrane potential, decrease mitochondrial superoxide, and inhibit cancer growth. It also prevents allergic reactions by preventing the release of histamine. The use of probiotic bacteria containing ddGTP may help in the treatment of inflammatory bowel disease.</p>

<p>5-Fluoro-2',3'-O-isopropylidenecytidine is a modified nucleoside that has antiviral and anticancer properties. It is a diphosphate of cytidine, with a fluorine atom in the 2'-position and an isopropyl group in the 3'-position. 5-Fluoro-2',3'-O-isopropylidenecytidine is synthesized by reacting 5-fluorocytidine with isopropylamine. This novel compound has been shown to have high quality, high purity, and improved biological activity as compared to other nucleosides.</p>

<p>5’-Deoxy-5’-iodouridine (5DIU) is an antiviral agent that inhibits the synthesis of DNA by interfering with the enzyme thymidine kinase, which converts thymine to uracil. It is used in the treatment of cutaneous herpes simplex virus infections. 5DIU has been shown to inhibit viral replication and yield in vitro. The drug showed no significant toxicity in mice, rats, or hamsters. In addition, it has been observed that 5DIU does not interfere with human cell growth, which may be due to its lack of activity against a wide range of human enzymes.</p>

<p>2-Amino-4-(thien-2-yl)pyrimidine is a bioavailable, water soluble antiallergy drug. 2-Amino-4-(thien-2-yl)pyrimidine has been shown to be effective against allergic asthma and other allergic diseases. It is thought to work by blocking the release of histamine from mast cells, thereby preventing the production of inflammatory prostaglandins and leukotrienes. This drug also blocks the response to allergies by inhibiting the release of IgE antibodies that bind to allergens. The therapeutic effect of 2-amino-4-(thien-2-yl)pyrimidine is repeatable and it does not cause any adverse effects on potassium or carbonate metabolism.</p>

<p>2',3'-Dideoxyadenosine-5'-triphosphate lithium salt is a nucleoside for use in research applications</p>

<p>a,b-Methyleneguanosine 5'-diphosphate sodium salt is a chemical species that binds to the influenza virus neuraminidase. The drug binding site on the influenza virus neuraminidase has been identified in high resolution by NMR and X-ray crystallography. This drug is able to inhibit the release of infectious particles and prevent infection by the influenza virus, which is an important biological weapon in bioterrorism. The compound is not active against other viruses such as HIV and herpes simplex virus type 1. In addition, this chemical species also inhibits the activity of geniculate nucleus neurons and may be effective for treatment of chronic pain caused by nerve injury.</p>

<p>Thymidine is a nucleoside that is a component of DNA and RNA. It is also the precursor for thymine, the DNA base in which the thymine ring is derived from. Thymidine has been shown to be an activator of DNA synthesis, as well as being anticancer and antiviral.</p>

<p>Uridine-2-13C is a modified nucleoside that is used as an anticancer agent. It is phosphorylated to uridine-2-13C diphosphate and can be used in DNA synthesis and as a radiolabel.</p>

<p>8-(2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridyl)-2'-deoxyguanosine (8-APdG) is a mutagen that induces genotoxic effects and mutations in mammalian cells. It has been shown to react with DNA to form covalent complexes and induce point mutations or transversions. 8-APdG has been found in the environment as a result of environmental pollution by polycyclic aromatic hydrocarbons and tobacco smoke. 8-APdG also induces genetic damage in human lymphoblastoid cells in vitro, including mutations at the HPRT locus.</p>

<p>Decanoyl CoA, free acid, is a substrate of the enzyme fatty acid synthetase. This enzyme catalyzes the formation of long-chain fatty acids from acetyl-CoA and malonyl-CoA. The product decanoyl-CoA is then used in other metabolic pathways to synthesize acyl chains for phospholipids, triglycerides, and cholesterol. Decanoyl CoA has been shown to inhibit carnitine acyltransferase activity in rat liver microsomes. It also inhibits mitochondrial beta-oxidation by competing with carnitine at the level of the carnitine acyltransferase reaction. The expression plasmid pET21a was used to express the decanoyl CoA synthetase protein in Escherichia coli cells grown in LB medium with aminotransferase activity as a measure of decanoyl CoA synthetase activity. Decanoyl CoA</p>

<p>T-705RTP sodium is a novel, modified diphosphate nucleotide that activates the formation of DNA and RNA. It is used as an antiviral and anticancer agent. T-705RTP sodium has been shown to be more potent than adenosine in inhibiting viral replication and has cytotoxic effects on cancer cells. The chemical formula for T-705RTP sodium is C6H14N5O7P.</p>

<p>2'-Azido-2'-deoxyuridine-5'-triphosphate is a nucleotide analog that is inactive in the presence of an intact receptor. It is an allosteric inhibitor of many DNA polymerases and causes cell growth inhibition. 2'-Azido-2'-deoxyuridine-5'-triphosphate binds to the phosphate group of ATP and inhibits protein synthesis. In particular, it inhibits the polymerase activity of herpes simplex virus type 1 by binding to the active site of the enzyme, thereby preventing viral replication. 2'-Azido-2'-deoxyuridine-5'-triphosphate also binds to cytosolic Ca2+ and activates Ca2+ signaling pathways, leading to cell death.</p>