Nucleosides

<p>N6-Benzoyl-3'-deoxy-5'-O-DMT-3'-fluoroadenosine is an activator nucleoside that is used as a phosphoramidite in DNA synthesis. It is also used in antiviral and anticancer therapies. N6-Benzoyl-3'-deoxy-5'-O-DMT-3'-fluoroadenosine has been shown to have high purity and high quality, making it suitable for use in the pharmaceutical industry. This product is not active against bacterial or viral infections, but has proved to be effective in the treatment of leukemia, lymphoma and other cancers.</p>

<p>5'-O-DMT-4-methoxythymidine 3'-CE phosphoramidite is a high purity, modified nucleoside with anticancer potential. It is an activator of DNA synthesis and inhibits the growth of tumor cells. This chemical is a monophosphate or diphosphate, depending on the conditions used in synthesis. 5'-O-DMT-4-methoxythymidine 3'-CE phosphoramidite is used to synthesize DNA, RNA, and deoxyribonucleosides. It is also used as a precursor for other ribonucleosides and nucleotides that are needed in the synthesis of DNA and RNA.<br>5'-O-DMT-4-methoxythymidine 3'-CE phosphoramidite can be synthesized from commercially available starting materials such as 4-(2-deoxyribofuranosyl)thymidine, 5-(3,</p>

<p>2'-Deoxy-5'-O-DMT-N6-phenoxyacetyladenosine 3'-Me phosphoramidite is a novel nucleoside analog with antiviral and anticancer activities. It inhibits viral replication by inhibiting the viral polymerase and cellular DNA polymerases. 2'-Deoxy-5'-O-DMT-N6-phenoxyacetyladenosine 3'-Me phosphoramidite also inhibits tumor growth by arresting cells in the G2/M phase of the cell cycle. This compound has been shown to be effective against human leukemia, lymphoma, breast cancer, and colon cancer cells.</p>

<p>3,4-dihydro-3-oxo-4-(2-pyrimidinyl)-2,5-dioxopyrrolidine carboxamide is an analog of acyclovir that has antiviral activity against a variety of viruses. It binds to the receptor binding site on the virus and prevents viral replication. 3,4-Dihydro-3-oxo-4-(2-pyrimidinyl)-2,5-dioxopyrrolidine carboxamide is effective against human influenza A virus (H1N1) and hepatitis B virus. This drug also has been shown to inhibit the growth of phlebovirus in cell culture by preventing the synthesis of viral RNA.</p>

<p>2,6-Dichloro-9-(2'-deoxy-β-D-ribofuranosyl)purine is a synthetic compound that is used in the treatment of certain types of cancer. It has been shown to be an activator of DNA synthesis and an inhibitor of RNA synthesis. It has also been shown to inhibit tumor growth and prolong the survival time for patients with leukemia. The antiviral activity of 2,6-dichloro-9-(2'-deoxy-β-D-ribofuranosyl)purine may be due to its ability to inhibit viral DNA polymerase. This drug is also known as dideoxyinosine (ddI).</p>

<p>2-[[4-[2-(tert-Butoxycarbonyl)ethyl]phenylethyl]amino]2',3'-O-isopropylideneadenosine-5'-N-ethylcarboxamide is a novel nucleoside that inhibits DNA synthesis and viral replication. It has been shown to be active against the herpes simplex virus type 1, influenza virus, and human immunodeficiency virus. 2-[[4-[2-(tert-Butoxycarbonyl)ethyl]phenylethyl]amino]2',3'-O-isopropylideneadenosine-5'-N-ethylcarboxamide is currently being developed as an anticancer drug. This molecule prevents tumor growth by inhibiting the proliferation of cancer cells.</p>

<p>8-Oxo-N2-isobutyryl-2-deoxyguanosine is a modified synthetic nucleoside.  It finds applications in understanding mutagenesis and DNA repair mechanisms.</p>

<p>N6-Benzoyl-3'-deoxy-5'-O-DMT-adenosine 2'-CE phosphoramidite is a novel modified nucleoside that has antiviral, anticancer and antibacterial properties. The chemical name is N6-benzoyl-3'-deoxy-5'-O-DMT-adenosine 2'-CE phosphoramidite. It is a ribonucleotide. It is an activator of the enzyme kinase A which phosphorylates proteins and activates them. This product has not been tested in humans.</p>

<p>5'-Azido-5'-deoxy-2',3'-O-isopropylideneadenosine (5ADeA) is a novel nucleoside with antiretroviral and antitumor activity. It is an activator of the innate immune system, which stimulates the production of cytokines such as TNF-α and IL-1β. This agent also inhibits viral replication by inhibiting viral RNA synthesis through its effect on the enzyme ribonucleotide reductase. 5ADeA monophosphate has been shown to be an effective antiviral against HIV and hepatitis C virus, as well as being active against human papilloma virus and Epstein-Barr virus. 5ADeA is synthesized in high purity and has a CAS number of 34245-48-2.</p>

<p>5'-O-(4,4'-Dimethoxy-4''-(1H,1H,2H,2H-perfluorodecyl)trityl)thymidine 3'-CE phosphoramidite is a novel nucleoside with antiviral activity. It is synthesized through the condensation of 5-bromo-2′-deoxyuridine and 4,4′-dimethoxytrityl chloride. This compound has been shown to inhibit the synthesis of DNA and RNA in vitro. It also has anticancer properties and can be used for the treatment of leukemia.</p>

<p>2'-Deoxy-5-iodouridine-5'-triphosphate sodium salt is a potent inhibitor of thymidylate synthase, an enzyme that catalyzes the conversion of deoxyuridine to thymidylate. 2'-Deoxy-5-iodouridine-5'-triphosphate sodium salt has been found to have a noncompetitive inhibition effect on bacterial DNA replication and is used as a chemotherapeutic agent in the treatment of cancer. It is also used as a radioprotectant during radiation therapy. The optimum concentration for 2'-deoxy-5-iodouridine-5'-triphosphate sodium salt is 10mM, which inhibits bacterial enzymes but does not inhibit mammalian enzymes.</p>

<p>N2-Benzoyl-9-(2'-deoxy-5'-O-DMT-2'-deoxy-b-D-ribofuranosyl)purine is a phosphoramidite that is used as a precursor for the synthesis of modified oligonucleotides. It is also active against cancer and antiviral pathogens. N2-Benzoyl-9-(2'-deoxy-5'-O-DMT-2'-deoxy-b-D ribofuranosyl)purine has been shown to inhibit viral replication in vitro by inhibiting the formation of viral DNA, RNA, and protein. This drug has been shown to inhibit the growth of mouse leukemia cells in vivo. It also inhibits DNA synthesis by binding to the enzyme DNA polymerase, which is required for replication of bacterial and viral DNA.</p>

<p>5'-O-DMT-5-methyl-(2'-O-4'-C-methylene)-uridine 3'-CE-phosphoramidite is a nucleoside phosphoramidite and an anticancer drug. It is a modified nucleoside that has been synthesized by the chemical reaction of 5'-O-dimethoxytritylthymidine with 5'-O-DMT-5-methyl-(2'-O-4'-C-methylene)uridine 3' chloroformate. 5'-O-DMT-5-methyl-(2'-O-4' -C methylene)-uridine 3' chloroformate is synthesized in three steps starting from 1,3,5,7,9,11,13,15,-hexahydrobenzo[a]pyrrolo[1,'c']azepin 2(3H)-one.</p>

<p>2'-Deoxyuridine-5'-[(a,b)-imido]diphosphate sodium salt - 10mM aqueous solution is an organic compound that is used as a plant growth regulator. It inhibits the activity of plant enzymes, such as adenylate cyclase and protein kinase C, thereby blocking the production of proteins in plants. 2'-Deoxyuridine-5'-[(a,b)-imido]diphosphate sodium salt - 10mM aqueous solution has been shown to be toxic to muscle tissue and can cause acute toxicity in mammals. However, it has been found to be safe for use on plants when diluted with water.</p>

<p>5-O-Tritylinosine is a modified nucleoside that has shown anticancer and antiviral properties. It is the monophosphate ester of 5-methyluracil and has been shown to inhibit DNA synthesis in vitro. 5-O-Tritylinosine has also been shown to inhibit the replication of herpes simplex virus type 1, which may be due to its ability to inhibit viral DNA polymerase.</p>

<p>5-Ethynylcytidine is a fluorescent analog of cytosine that has been synthesized for use in biochemical research. It is used to identify cellular sites of RNA synthesis and replication, as well as to study the role of the 5-ethynyl group in the mechanism of DNA methylation. The synthetic route starts with an azide intermediate which is then treated with sodium hydroxide, followed by hydrolysis and demethylation. 5-Ethynylcytidine has been shown to be selective for mammalian cells and tissues, and was incubated with calf thymus DNA for crystallographic data.</p>

<p>4'-a-C-Methyladenosine is a nucleoside that has antiviral, anticancer and novel properties. It is a modified nucleoside with a methyl group in the 4' position. This modification prevents the phosphodiester bond from being hydrolyzed by nucleotide kinase enzymes. The methyl group also inhibits the formation of adenosine monophosphate (AMP) during DNA synthesis, which prevents the deactivation of adenosine triphosphate (ATP). 4'-a-C-Methyladenosine is used to synthesize oligonucleotides for use in DNA sequencing and gene mapping.</p>

<p>5’-Azido-2’,5’-dideoxyuridine (5ADU) is a pyrimidine nucleoside that has been used to treat cancer. It is converted to 5-azidouracil which inhibits the synthesis of thymidylate, an essential component of DNA. 5ADU is also active against herpes virus and can be used as an antiviral agent. This drug has been shown to protect against radiation damage by inhibiting the formation of free radicals. The protonation of 5ADU leads to a stereochemical rearrangement that prevents the formation of free radicals. 5ADU does not inhibit bacterial enzymes, but it does have some effect on viruses, such as herpes virus, because they contain DNA or RNA similar to human cells.</p>

<p>5-[N(6-(Trifluoroacetamido)hexyl)-3-(E)-acrylamido] -2'-deoxyuridine is a synthetic, modified nucleoside that functions as an activator of ribonucleotide reductase. It has been shown to be effective in the treatment of viral infections, including herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), and human immunodeficiency virus type 1 (HIV-1). 5-[N(6-(Trifluoroacetamido)hexyl)-3-(E)-acrylamido] -2'-deoxyuridine is also synthesized into DNA or RNA molecules, which are used to study the structure of these compounds. It can also be used for phosphoramidite synthesis.</p>

<p>N4-Benzoyl-2'-deoxy-3'-O-levulinoylcytidine is a nucleoside that is used as an antiviral and anticancer agent. It is a modified deoxyribonucleoside that has antiviral activity against HSV-1, HSV-2, and HIV. N4-Benzoyl-2'-deoxy-3'-O-levulinoylcytidine also has anticancer effects against leukemia cells in mice. This drug is synthesized from 2′,3′,5′triacetyladenosine by the reaction of 4-(1H)-benzoyloxymethyl)phenylacetic acid with triethylamine and levulinic acid chloride.</p>