Nucleosides

2'-Deoxy-2'-fluoro-5-methylcytidine 5'-triphosphate is a novel antiviral and antitumor agent, which is synthesized from 2'-deoxy-2'-fluoro-5-methylcytidine. This compound is a cytosine ribonucleotide analog that can be activated to form the corresponding triphosphate. Its chemical name is 5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-fluoro-5-methylcytidine 5',3' -O-(1,1,3,3,-tetraisopropyldisiloxanyl) diphosphate. The CAS number for this compound is 847647-94-3.

5-Formyl-2'-O-methyluridine is a nucleoside that can be used as an antiviral and anticancer agent. It is a novel modified monophosphate nucleotide analog with high purity and high quality. 5-Formyl-2'-O-methyluridine has shown to inhibit the growth of cancer cells in vitro and to reduce tumor size in vivo. It also inhibits viral replication by inhibiting viral DNA synthesis. 5-Formyl-2'-O-methyluridine has been shown to be an effective inhibitor of HIV and HSV, where it has been found to inhibit the synthesis of viral RNA, which prevents the virus from replicating.

5'-O-Tritylthymidine 3'-CE phosphoramidite is a synthetic, modified nucleoside. It is an ester of thymidine and trityl chloride. 5'-O-Tritylthymidine 3'-CE phosphoramidite is used as an anticancer drug and has been shown to activate the transcription of ribonucleic acid (RNA) in vitro, which may be due to inhibition of the enzyme RNA polymerase II. This product has also been shown to have antitumour activity against human colon and ovarian cancer cells in vivo.

3'-Amino-N4-benzoyl-5'-O-tert-butyldimethylsilyl-2',3'-dideoxycytidine (3'-ABT) is a novel diphosphate nucleoside that has been used in clinical trials as an activator of anticancer drugs. 3'-ABT is also used as a building block for synthesis of 2',3'-dideoxyuridine, which has antiviral properties. 3'-ABT can be synthesized by reacting N4-benzoyl-5'-O-tert-butyldimethylsilylcytosine with sodium bis(trimethylsilyl)amide and 2,6,8,10,-dodecatriene.

Clevudine is a synthetic pyrimidine analogue effective against the hepatitis B virus (HBV). Once inside the cell, it is converted into its active forms, clevudine monophosphate and clevudine triphosphate. The triphosphate form competes with thymidine to be incorporated into viral DNA, leading to DNA chain termination and inhibition of the HBV DNA polymerase (reverse transcriptase). Due to its long half-life, clevudine significantly reduces covalently closed circular DNA (cccDNA), making relapse less likely after treatment ends.

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An azanucleoside and epigenetic modulator that interferes with nucleic acid metabolism. The compound gets incorporated into RNA and inhibits ribonucleotide reductase subunit RRM2 in leukemia cell lines. Intracellularly, 5-azacytidine can get converted into 2′-deoxy-5-azacytidine (decitabine) and subsequently incorporated in DNA, where it irreversibly inhibits DNMT1 methyltransferase. In human epithelial cell lines, this compound decreases Src-activated expression of a histone chaperone CAF1 and inhibits cell motility and invasiveness.

3'-Deoxyuridine is a synthetic antibiotic that is used in the treatment of viral infections, such as hepatitis B and C, and HIV. 3'-Deoxyuridine competitively inhibits the synthesis of RNA by binding to the enzyme RNA polymerase. This drug also has antiviral activity against the human cytomegalovirus (CMV) and Hepatitis C virus (HCV). 3'-Deoxyuridine is synthesized from uracil in an organic solvent, trifluoroacetic acid, at low temperatures. The incorporation of deoxynucleoside triphosphates into DNA occurs after cleavage of the terminal phosphate group by water vapor.

3'-Amino-5'-O-benzyl-3'-deoxy-D3-thymidine is a novel antiviral agent that inhibits the replication of retroviruses. It is an activator of ribonucleotide reductase, which converts ribonucleotides to deoxyribonucleotides. The drug has been shown to inhibit DNA and RNA synthesis in vitro. 3'-Amino-5'-O-benzyl-3'-deoxy-D3-thymidine is also being studied for its anticancer properties.

5'-O-Methoxytrityluridine 3'-CE phosphoramidite is a modified nucleoside that can be used in the synthesis of DNA and RNA. It is an activator that activates ribonucleotides to diphosphates. 5'-O-Methoxytrityluridine 3'-CE phosphoramidite has been shown to have antiviral, anticancer, and novel activities. This product is CAS No. 57747-00-2, High purity, deoxyribonucleosides, and high quality.

3′-UMP is a modified nucleoside that has antiviral activity, and is synthesized by the phosphoramidite method. It is a novel compound, which has not been previously reported. 3′-UMP is an activator of ribonucleotide reductase and can be used to treat viral infections. This drug also has anticancer effects and can be used as a chemotherapeutic agent for the treatment of leukemia. 3′-UMP has high purity and high quality.

4’-C-Methyl-5-methylcytidine is a phosphoramidite nucleoside that is used as a reagent in the synthesis of DNA. It is modified with a 4′-methyl and 5′-methyl group at the C4 and C5 positions of the cytosine base, respectively. The 4′-C methyl group is an antiviral agent that inhibits viral replication by inhibiting reverse transcriptase. The 5′-methyl group prevents deamination of cytosine residues by inhibiting uracil glycosylase. This product has anticancer properties due to its ability to inhibit cell division and activate apoptosis in tumor cells.

1-(2'-Deoxy-5'-O-DMT-b-D-xylofuranosyl) cytosine is a modified nucleoside that is phosphoramidite activated by the addition of a diphosphate. The diphosphate group on the sugar moiety may be hydrolyzed to form 1-(2'-deoxy-5'-O-DMT-b-D-xylofuranosyl)cytosine monophosphate. Cytidine is an antiviral and antifungal agent that is used in the treatment of herpes zoster, chronic myeloid leukemia, and other cancers. It has been shown to inhibit DNA synthesis and viral replication in vitro.
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Cytidine is an antiviral and antifungal agent that is used in the treatment of herpes zoster, chronic myeloid leukemia, and other cancers. It has been shown to inhibit DNA

2,2'-Anhydro-5'-O-toluoyluridine is a synthetic nucleoside analog that is used as an antiviral agent for the treatment of herpes simplex virus. It activates ribonucleotide reductase and inhibits DNA synthesis by inhibiting the enzyme DNA polymerase. 2,2'-Anhydro-5'-O-toluoyluridine has been shown to be active against colon cancer cells in vitro and in vivo. This drug has also been shown to inhibit the growth of certain types of leukemia cells and may be useful in treating patients with chronic myeloid leukemia.

(E)-Ferulic acid 4-O-β-D-glucoside is made up of ferulic acid, which is a natural compound found in things like rice, wheat and oats. Attached to this is a glucose molecule. This product can be used in research and potential be used to study its potential health benefits.

3'-O-Amino-2'-deoxycytidine (3'-AAC) is an activator nucleoside that has antiviral and anticancer properties. It can be used with other anticancer agents such as doxorubicin, methotrexate, and 5-fluorouracil to increase the efficacy of these compounds. 3'-AAC is a phosphoramidite monophosphate that can be used in the synthesis of oligodeoxynucleotides. This product is also a novel chemical entity that has not been previously described in any publication or patent application.

5-Methoxy-4’-thiouridine is a monophosphate nucleoside that is synthesized by the phosphorylation of 5-methoxy-4’-thioguanosine. It has antiviral activity, which is due to its ability to inhibit viral DNA polymerase and prevent the production of viral DNA. 5-Methoxy-4’-thiouridine also inhibits the synthesis of deoxyribonucleosides and ribonucleosides, thereby preventing the formation of RNA and DNA. This agent has been shown to be an anticancer agent that can cause cell death by inhibiting protein synthesis.

5'-O-Tosyl-2',3'-O-isopropylideneadenosine is a novel modified nucleoside with antiviral and anticancer activities. It is an activator of the enzyme ribonucleotide reductase, which converts ribonucleotides to deoxyribonucleotides. This drug has been shown to have anticancer activity in a variety of tumor cell lines, including leukemias, lymphomas, and sarcomas. In addition, it has been shown to be active against HIV and herpes simplex virus type 1 (HSV-1). 5'-O-Tosyl-2',3'-O-isopropylideneadenosine is also known by CAS No. 5605-63-0.