Nucleosides

<p>Please enquire for more information about 3’,5’-Di-O-acetyl-2’-azido-2’-deoxyuridine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2'-O-Acetyl-8-bromo-7-cyano-7-deaza-3'-deoxy-3'-fluoro-5'-O-[toluoyl]adenosine (ABT) is a modified nucleoside that has anticancer and antiviral properties. ABT is a monophosphate nucleotide with an acetyl group at the 2' position of the ribose and a toluoyl group on the 7 position of the adenine moiety. In vitro, ABT inhibits tumor proliferation in breast cancer cells and suppresses viral replication in herpes simplex virus type 1 (HSV1) infected cells. ABT also has potential as a novel therapeutic agent for treating cancers and other diseases caused by HSV1 infection.</p>

<p>10-O-[1-Propyl-3-N-carbamoylcholesteryl]-TEG-CE phosphoramidite is a cholesterol-conjugated phosphoramidite. The cholesteryl group is a lipophilic moiety which can be used to enhance cellular uptake of oligonucleotides.</p>

<p>8-azido-2-deoxyadenosine is an azide funcationalised nuceleoside</p>

<p>5'-O-Methoxytrityluridine 3'-CE phosphoramidite is a modified nucleoside that can be used in the synthesis of DNA and RNA. It is an activator that activates ribonucleotides to diphosphates. 5'-O-Methoxytrityluridine 3'-CE phosphoramidite has been shown to have antiviral, anticancer, and novel activities. This product is CAS No. 57747-00-2, High purity, deoxyribonucleosides, and high quality.</p>

<p>CTP serves as a molecule of high energy. It acts as a coenzyme in glycerophospholipid biosynthesis and protein glycosylation.</p>

<p>5'-(Furan-2-yl)-2’-O-methyluridine is a modified nucleoside that is used as an antiviral agent. It is a monophosphate nucleotide analog and has been shown to be active against HIV, herpes simplex virus, cytomegalovirus, and Epstein Barr virus. 5'-(Furan-2-yl)-2’-O-methyluridine is synthesized by the phosphoramidite method and has high purity and quality. The CAS number for this compound is 2095417-32-4.</p>

<p>Clofarabine is a nucleoside analog that is used to treat various types of cancer, including leukemia, lymphoma, and solid tumours. Clofarabine has been shown to have minimal toxicity in healthy cells and is usually well tolerated by patients. It acts by inhibiting the synthesis of DNA in rapidly dividing cells. This effect can be synergistic with other anti-cancer agents such as the cytotoxic agent Bleomycin. Clofarabine binds to an intracellular target and inhibits DNA synthesis by blocking the enzyme DNA polymerase. Inhibition of this enzyme leads to cell death. Clofarabine has been tested in pediatric patients from age 1 month old up to 18 years old. The drug has been found to be safe for use in this population.</p>

<p>5'-(Furan-2-yl)-5'-O-DMT-2’-O-methylcytidine is a high purity phosphoramidite, deoxyribonucleoside, and ribonucleoside that can be used in the synthesis of antiviral drugs, anti-cancer agents, and nucleotides. 5'-(Furan-2-yl)-5'-O-DMT-2’-O-methylcytidine has been shown to inhibit the growth of various cancer cells. This product also belongs to a novel class of synthetic nucleosides that can be modified with fluorine or other substituents at any position on the sugar ring.</p>

<p>3-Cyanovinyl-9-(5’-O-DMT-2’-deoxyribofuranosyl)carbazole is a nucleoside analog that is an antiviral and anticancer agent. It is a monophosphate, which has been shown to inhibit the replication of DNA by binding to the enzyme DNA polymerase. 3-Cyanovinyl-9-(5’-O-DMT-2’-deoxyribofuranosyl)carbazole also inhibits protein synthesis and cell division by preventing the production of proteins vital for cell division. This drug has shown high purity and quality, as well as novel properties.</p>

<p>5'-O-DMT-2'-O,4'-C-methylene-5-methyluridine 3'-CE-phosphoramidite is a high purity, novel DNA monophosphate that is synthesized from 2',4'-diaminotoluene and 5'-O-dimethoxytritylthymidine. It has antiviral and anticancer properties and has shown to be an activator of RNA polymerase II in vitro. This product is used in many applications such as the synthesis of oligonucleotide probes for DNA sequencing, the synthesis of RNA for gene expression studies, and for the production of oligonucleotides for therapeutic purposes.</p>

<p>5'-O-DMT-N4-isobutyryl-2'-O-methylcytidine is a novel, synthetic nucleoside. It is a phosphoramidate prodrug of 5'-deoxy-5'-O-dimethoxytrityl-N4-isobutyrylcytidine, which is an antiviral and anticancer agent. 5'-O-DMT-N4-isobutyrylcytidine inhibits DNA synthesis by competitively inhibiting the activity of the enzyme ribonucleotide reductase (RNR).</p>

<p>5-Iodouridine is a pyrimidine nucleoside that is found in the human body. It is used as a starting material for the synthesis of 5-iodo-2'-deoxyuridine, which has been shown to have biological properties. 5-Iodouridine binds to the dna template and prevents radiation from altering it's conformation. This binding has been shown to be specific for ultraviolet (UV) radiation, with little absorption at visible wavelengths. The biological effects of 5-iodouridine are dependent on its acidic pH and hydrogen bonding ability. In vitro assays have demonstrated that this compound can inhibit prostate cancer cells from proliferating and may be useful in treating cervical cancer.</p>

<p>3'-Amino-5'-O-p-anisoyl-2',3'-dideoxyuridine is a novel compound that has been synthesized. This compound is a diphosphate, which can be used as an activator for the synthesis of modified nucleosides and antiviral agents. It is also a DNA phosphoramidite, which can be used in the synthesis of oligonucleotides with high purity and high quality.</p>

<p>N1-Ethylpseudouridine is a synthetic RNA molecule that has been shown to be an effective antiviral agent against influenza virus in cell culture. It inhibits viral replication by binding to the ribonucleic acid (RNA) of the virus and preventing its translation into protein. N1-Ethylpseudouridine is being developed as a potential treatment for influenza A and B.</p>

<p>2'-Deoxy-N2-isobutyryl-5'-O-MMT-guanosine is a synthetic, modified nucleoside. It is an activator of DNA synthesis, and it has been found to inhibit the growth of cancer cells in vitro. This compound has shown success in the treatment of HIV infection in vitro and has also been shown to be effective against hepatitis B virus (HBV) and herpes simplex virus type 1 (HSV). The compound may be useful as an antiviral agent.</p>

<p>Cytidine based prodrug with gemcitabine is a nucleoside analog that has antiviral and anticancer properties. It is a modified cytidine-based prodrug with gemcitabine which is an anticancer drug. Cytidine based prodrug with gemcitabine inhibits viral DNA synthesis by competitively inhibiting the incorporation of deoxycytidine monophosphate into the viral DNA chain. The prodrug also inhibits the proliferation of cancer cells by interfering with DNA synthesis, which leads to cell death.</p>

<p>N6-Benzoyl-2',3'-isopropylideneadenosine is a nucleoside that is structurally related to the natural nucleosides adenosine, deoxyadenosine, and deoxyguanosine. It is an antiviral agent that has been shown to be an activator of the enzyme ribonucleotide reductase. N6-Benzoyl-2',3'-isopropylideneadenosine is a modified nucleoside with high purity and high quality. The CAS number for this compound is 39947-04-1. This compound has not been found in nature, but it can be synthesized by modifying nucleosides or by using phosphoramidites.</p>

<p>guanosine 5'-monophosphate calcium salt is a dietary supplement that contains calcium carbonate and guanosine 5'-monophosphate. This product is a light-exposed supplement that contains phenolic acids, polycarboxylic acids, and cyclic nucleotide phosphodiesterases. It is used to maintain ATP levels in the body. Guanosine 5'-monophosphate calcium salt should not be taken by people with a history of kidney stones or those taking other supplements containing calcium. This product may contain preservatives, excipients, or pharmaceutical ingredients for potency and stability purposes.</p>

<p>1-(b-D-Xylofuranosyl)-2-thiouracil is a synthetic nucleoside that inhibits viral and cancer cell growth. It is an analog of the natural nucleoside thymidine, with an extra oxygen atom at position 2. The molecule forms a monophosphate, which is converted to a diphosphate by phosphoramidate synthase. This diphosphate is then incorporated into DNA, where it inhibits the activity of DNA polymerase and deoxyribonucleases, leading to inhibition of DNA synthesis. 1-(b-D-Xylofuranosyl)-2-thiouracil also has antiviral properties as it can inhibit viral replication by blocking the incorporation of nucleotides into the growing DNA strand.</p>