Antidepressant

Impurity Fluoxetine USP Related Compound A
Applications Fluoxetine (F597100) meta isomer. Fluoxetine impurity. Fluoxetine USP Related Compound A.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wong, D.T., et al.: J. Pharmacol. Experim. Therap., 193, 804 (1975),

Applications 2-Hydroxydesipramine Dihydrochloride is a metabolite of Desipramine (D290050), a tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter.
References De Jongh, G.D., et al.: Drug Metab. Dispos., 2, 48 (1981); Suckow, R.F., et al.: J. Pharm. Sci., 73, 1745 (1984); Fraser, A.D., et al.: J. Anal. Toxicol., 11,168 (1987); Checkley, S.A, et al.: Br. J. Psychiatry, 138. 248 (1981); Zhu, M.Y., et al.: J. Neurochem., 70, 1547 (1998); Okugawa, G., et al.: J. Neuroindocrinol., 11, 887 (1999); Torres, G.E., et al.: Nat. Rev. Neurosci., 4, 13 (2003)

Applications Cyclizine is a piperazine derivative with anti-emetic activity that is useful in the prevention and treatment of nausea and vomiting associated with motion sickness. Antiemetic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kuntzman, R., et al.: J. Pharmacol. Exp. Ther., 158, 332 (1967), Walker, R., et al.: Eur. J. Pharm. Sci., 4, 301 (1996), Dumasia, M., et al.: Xenobiotica, 32, 795 (2002),

Impurity Fluvoxamine EP impurity D
Applications Fluvoxamine intermediate.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kamlet, M., et al.: J. Phys. Chem., 92, 5244 (1988), Terabe, S., et al.: J. Pharm. Biomed. Anal., 10, 705 (1992), Altria, K., et al.: J. Pharm. Biomed. Anal.,18, 807 (1998),

Applications Intermediate in the preparation of (S)-Norfluoxetine
References Zhang, P., et al.: Bioorg. Med. Chem. Lett., 18, 6067 (2008), Graves, A., et al.: J. Mol. Biol., 377, 914 (2008), Cashman, J., et al.: Bioorg. Med. Chem., 17, 337 (2009),

Applications A metabolite of Clomipramine.
References McTavish, D., et al.: Drugs, 39, 136 (1990), Chauret, N., et al.: Drug Metab. Dispos., 25, 1130 (1997), Gex-Fabry, M., et al.: Ther. Drug Monit., 22, 701 (2000), Herrera, D., et al.: J. Clin. Pharmacol., 40, 1488 (2000),

Impurity Fluvoxamine EP impurity B
Applications The geometric isomer of the second-generation antidepressant Fluvoxamine.
References Palego, L., et al.: Ther. Drug Monit., 22, 190 (2000), Miolo, G., et al.: Eur. J. Pharmacol., 450, 223 (2002), Hostetter, A., et al.: Ther. Drug Monit., 26, 47 ( 2004), Stahl, S., et al.: Curr. Med. Chem., 11, 313 (2004), Kwon, J., et al.: J. Pharmaceut. Biomed., 37, 643 (2005)

Applications The (S)-isomer of Viloxazine (V312440). Antidepressant.
References Howe, R., et al.: J. Med. Chem., 19, 1074 (1976), Pinder, R.M., et al.: Drugs, 13, 401 (1977),

Applications An impurity of Fluvoxamine maleate tablets.

Applications (E)-1-(4-(Trifluoromethyl)phenyl)pentan-1-one Oxime is an impurity in the synthesis of Fluvoxamine (F603500), a selective serotonin reuptake inhibitor (SSRI) used as an anti-depressant. Antiobsessional.

Applications 5-Allylidene-10,11-dihydro-5H-dibenzo[a,d][7]annulene is an impurity of Nortriptyline (N837000) and Amitriptyline (A552600), both of which are antidepressant.
References Hale, J. L., et al.: Anal. Profiles Drug Subs., 1, 233 (1972); Rubin, E.H., et al.: J. Clin. Psychiatry, 46, 418 (1985); Blessel, K.W., et al.: Anal. Profiles Drug Subs., 3, 127 (1974); Tobe, A., et al.: Arzneim.-Forsch., 31, 1278 (1981)

Applications Dendrobine is an alkaloid isolated from Dendrobium nobile and is an antagonist of β-alanine, taurine and of presynaptic inhibition in the frog spinal cord.
References Kudo, Y., et. al.: Brit. J. Pharmacol., 78, 709 (1983)

Impurity Duloxetine Phthalamide Impurity
Applications (S)-Duloxetine Phthalamide is an impurity of (S)-Duloxetine present with enteric polymer hydroxypropylmethylcellulose phthalate (HPMCP) in dosage formulations.
References Jansen, P.J., et al.: J. Pharmaceut. Sci., 87, 81 (1998),

Applications rac-cis-N-Desmethyl Sertraline-d3 hydrochloride is a labelled metabolite of rac-cis-N-Desmethyl sertraline hydrochloride (D292100). N-Desmethyl sertraline is significantly less active analogue as compared to the methylated compound, sertraline.
References Welch, W.M., et al.: J. Med. Chem. 27, 1508 (1984)

Applications A metabolite of Fluvoxamine (F603500).
References Ruijten, H.M., et al.: Drug Metab. Dispos., 12, 82 (1984),

Applications (±)-Fluoxetine-d5 Oxalate (phenyl-d5) (CAS# 1219804-82-6) is a useful isotopically labeled research compound.