Antidepressant

Applications (E)-1-(4-(Trifluoromethyl)phenyl)pentan-1-one Oxime is an impurity in the synthesis of Fluvoxamine (F603500), a selective serotonin reuptake inhibitor (SSRI) used as an anti-depressant. Antiobsessional.

Impurity Duloxetine Phthalamide Impurity
Applications (S)-Duloxetine Phthalamide is an impurity of (S)-Duloxetine present with enteric polymer hydroxypropylmethylcellulose phthalate (HPMCP) in dosage formulations.
References Jansen, P.J., et al.: J. Pharmaceut. Sci., 87, 81 (1998),

Applications Dendrobine is an alkaloid isolated from Dendrobium nobile and is an antagonist of β-alanine, taurine and of presynaptic inhibition in the frog spinal cord.
References Kudo, Y., et. al.: Brit. J. Pharmacol., 78, 709 (1983)

Impurity Fluvoxamine EP impurity D
Applications Fluvoxamine intermediate.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kamlet, M., et al.: J. Phys. Chem., 92, 5244 (1988), Terabe, S., et al.: J. Pharm. Biomed. Anal., 10, 705 (1992), Altria, K., et al.: J. Pharm. Biomed. Anal.,18, 807 (1998),

Applications (±)-Fluoxetine-d5 Oxalate (phenyl-d5) (CAS# 1219804-82-6) is a useful isotopically labeled research compound.

Applications A metabolite of Fluvoxamine (F603500).
References Ruijten, H.M., et al.: Drug Metab. Dispos., 12, 82 (1984),

Applications 5-Allylidene-10,11-dihydro-5H-dibenzo[a,d][7]annulene is an impurity of Nortriptyline (N837000) and Amitriptyline (A552600), both of which are antidepressant.
References Hale, J. L., et al.: Anal. Profiles Drug Subs., 1, 233 (1972); Rubin, E.H., et al.: J. Clin. Psychiatry, 46, 418 (1985); Blessel, K.W., et al.: Anal. Profiles Drug Subs., 3, 127 (1974); Tobe, A., et al.: Arzneim.-Forsch., 31, 1278 (1981)

Applications Fluoxetine (F597100) derivative. A stereoselective inhibitor of serotonin re-uptake and phosphodiesterase. Potential antidepressants
References Cashman, J. et al.: Bioorgan Med. Chem. 17, 337 (2009)

Applications rac-cis-N-Desmethyl Sertraline-d3 hydrochloride is a labelled metabolite of rac-cis-N-Desmethyl sertraline hydrochloride (D292100). N-Desmethyl sertraline is significantly less active analogue as compared to the methylated compound, sertraline.
References Welch, W.M., et al.: J. Med. Chem. 27, 1508 (1984)