Valganciclovir and Impurities

<p>Valganciclovir, a prodrug of ganciclovir, treats CMV infections and inhibits PEPT1/PEPT2; demonstrated non-inferior to GCV with similar toxicity.</p>

<p>Applications N-Methyl Valganciclovir Hydrochloride is an impurity of Valganciclovir (V092000), a pro-drug of Ganciclovir (G235000) and antiviral agent.<br>References Acosta, E., et al.: Clin. Pharmacol. Ther., 81, 867 (2007); Nassetta, L., et al.: J. Antimicrob. Chemother., 63, 862 (2009); Suresh. K.R., et al.: J. Pharma. Biomed. Anal., 70, 101 (2012);<br></p>

<p>Valganciclovir related compound G is a drug product. It has been synthesized in our lab. Valganciclovir related compound G is not an approved drug and is not currently available in the market. Valganciclovir related compound G is a high purity analytical standard that can be used for metabolism studies, natural product research, synthetic research, and pharmacopoeia. Valganciclovir related compound G is a metabolite of valganciclovir and can be used as an impurity standard for HPLC analysis.</p>

<p>(S,S)-IsoValganciclovir hydrochloride is a drug product with a purity of 99.5% or greater that is used as a reference standard in drug development and analytical chemistry. It is metabolized to (2R,3R)-2-Amino-3-hydroxypropanoic acid by the enzyme valganciclovir hydrolase. The chemical name for (S,S)-IsoValganciclovir hydrochloride is 2-(Aminomethyl)valganciclovir. The CAS registry number for this compound is 1401562-13-7.</p>