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G-protein Coupled Receptors and 7-TM Receptors

G-protein Coupled Receptors and 7-TM Receptors

G-protein coupled receptors (GPCRs) and 7-transmembrane (7-TM) receptors are a large family of membrane proteins that play key roles in cellular communication and signal transduction. These receptors are involved in a wide range of physiological processes, including sensory perception, immune response, and hormone regulation. GPCRs are major targets in drug discovery, making them essential for research in pharmacology and medicine. At CymitQuimica, we offer a comprehensive selection of high-quality reagents and compounds related to GPCRs and 7-TM receptors to support your research and drug development efforts.

Found 5800 products of "G-protein Coupled Receptors and 7-TM Receptors"

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  • R-137696
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    R-137696

    CAS:
    R-137696 is an orally active 5-HT1A receptor agonist that facilitates the relaxation of the proximal stomach. It is utilized in research related to functional dyspepsia.
    Formula:C17H23N3O2
    Color and Shape:Solid
    Molecular weight:301.38

    Ref: TM-T201501

  • APJ receptor agonist 8
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    APJ receptor agonist 8

    CAS:
    <p>APJ receptor agonist 8 is a small molecule agonist of the APJ receptor, enhancing load-independent cardiac contractility in isolated perfused rat hearts.</p>
    Formula:C24H27N7O5S
    Purity:98.31% - 99.60%
    Color and Shape:Solid
    Molecular weight:525.58

    Ref: TM-T85710

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    IMP-1575

    CAS:
    IMP-1575 is a highly effective inhibitor of hedgehog acyltransferase (HHAT), with an IC50 of 0.75 μM when inhibiting purified HHAT. IMP-1575 has potential applications in cancer research.
    Formula:C19H25N3OS
    Molecular weight:343.49

    Ref: TM-T209044

  • Leukotriene B4 dimethyl amide
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    Leukotriene B4 dimethyl amide

    CAS:
    LTB4 dimethyl amide: inhibits human neutrophil degranulation and rat lysozyme release; antagonizes LTB4 receptor on guinea pig lung membranes (Ki = 130 nM).
    Formula:C22H37NO3
    Color and Shape:Solid
    Molecular weight:363.53

    Ref: TM-T37618

  • NBI 35965 hydrochloride
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    NBI 35965 hydrochloride

    CAS:
    NBI 35965 hydrochloride is a selective CRF1 (corticotropin-releasing factor receptor 1) antagonist that is both orally active and capable of penetrating the brain. It possesses a K i value of 4 nM and a pK i of 8.5, and does not affect CRF2. This compound effectively diminishes CRF or stress-triggered ACTH (adrenocorticotropic hormone) production in vivo, demonstrating pIC 50 values of 7.1 and 6.9. Additionally, NBI 35965 hydrochloride exhibits anxiolytic properties [1] [2].
    Formula:C21H23Cl3N4
    Color and Shape:Solid
    Molecular weight:437.79

    Ref: TM-T86978

  • Sigma-1 receptor antagonist 6
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    Sigma-1 receptor antagonist 6

    CAS:
    <p>Sigma-1 receptor antagonist 6 (Compound 12), a σ1R antagonist, demonstrates significant antiallodynic effects by targeting the Sigma-1 receptor (σ1R). This compound is effective in animal models for neuropathic pain, particularly for reducing mechanical allodynia caused by paclitaxel.</p>
    Formula:C32H34N6
    Color and Shape:Solid
    Molecular weight:502.65

    Ref: TM-T89901

  • CP-199330
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    CP-199330

    CAS:
    CP-199330: non-toxic alternative to Zafirlukast & Pranlukast, blocks cysteyl LT1 receptors.
    Formula:C28H24ClF3N2O6S
    Color and Shape:Solid
    Molecular weight:609.01

    Ref: TM-T31043

  • F 14679
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    F 14679

    CAS:
    <p>F 14679 is a potent 5-HT1A agonist (pKi=10.23) with a maximum Ca2t response similar to 5-HT.</p>
    Formula:C21H25ClF2N4O
    Purity:99.09%
    Color and Shape:Solid
    Molecular weight:422.9

    Ref: TM-T62269

  • GPR27 agonist-1
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    GPR27 agonist-1

    CAS:
    GPR27 agonist-1 (compound I) is a selective agonist for GPR27 with a pEC50 value of 6.34.
    Formula:C19H14Cl2N2O3S
    Color and Shape:Solid
    Molecular weight:421.30

    Ref: TM-T201309

  • LK-732
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    LK-732

    CAS:
    LK-732 is a thrombin inhibitor with antithrombotic activity. It exhibits dose-dependent inhibition in models of hypercoagulability, with an IC50 value of 1.3 mg/kg. LK-732 is used in cardiovascular and cerebrovascular research.
    Formula:C25H29N5O3S
    Color and Shape:Solid
    Molecular weight:479.59

    Ref: TM-T201818

  • Nedemelteon
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    Nedemelteon

    CAS:
    <p>Nedemelteon is an agonist of the melatonin receptor (melatonin receptor).</p>
    Formula:C15H18N2O2
    Color and Shape:Solid
    Molecular weight:258.32

    Ref: TM-T201036

  • Fosrolapitant
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    Fosrolapitant

    CAS:
    Fosrolapitant is an antagonist of the neurokinin 1 (NK1) receptor.
    Formula:C27H29F6N2O8P
    Color and Shape:Solid
    Molecular weight:654.49

    Ref: TM-T201161

  • MRS4833
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    MRS4833

    CAS:
    MRS4833 (compound 15) is an orally active, potent, competitive antagonist of P2Y14R, exhibiting IC50 values of 5.92 nM for hP2Y14R and 4.8 nM for mP2Y14R. It reduces airway eosinophilia in protease-mediated asthma models and reverses chronic neuropathic pain in mouse CCI models.
    Formula:C30H24F3NO3
    Color and Shape:Solid
    Molecular weight:503.51

    Ref: TM-T200837

  • Neflumozide
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    Neflumozide

    CAS:
    Neflumozide (HRP 913) is an orally effective derivative of benzisoxazole, characterized by its potent dopamine antagonist properties and antipsychotic activity. It is utilized in research related to psychiatric disorders.
    Formula:C22H23FN4O2
    Color and Shape:Solid
    Molecular weight:394.44

    Ref: TM-T201050

  • LB-102
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    LB-102

    CAS:
    LB-102 is an orally active inhibitor of dopamine D2, D3, and serotonin 5-HT7 receptors, utilized in the study of schizophrenia and other psychiatric disorders.
    Formula:C18H29N3O4S
    Color and Shape:Solid
    Molecular weight:383.51

    Ref: TM-T200914

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    SSR 146977 hydrochloride

    CAS:
    SSR 146977 hydrochloride is a potent, selective antagonist of the tachykinin NK 3 receptor, and it can be utilized in research on psychiatric disorders and airway inflammation [1].
    Formula:C35H43Cl3N4O2
    Molecular weight:658.1

    Ref: TM-T87440

  • Nipradolol
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    Nipradolol

    CAS:
    Nipradolol blocks alpha-1-adrenergic receptors, lowers IOP in rabbits, and reduces NA-induced muscle contraction and dog artery vasodilation.
    Formula:C15H22N2O6
    Color and Shape:Solid
    Molecular weight:326.35

    Ref: TM-T73083

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    SLF1081851 hydrochloride

    CAS:
    SLF1081851 (hydrochloride), a Spns2 inhibitor, effectively inhibits S1P release with an IC50 value of 1.93 μM. This compound is instrumental in the development and functioning of the immune system [1].
    Formula:C21H34ClN3O
    Molecular weight:379.97

    Ref: TM-T87408

  • Sulfinalol hydrochloride
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    Sulfinalol hydrochloride

    CAS:
    Sulfinalol hydrochloride is an orally active β-adrenoceptor (β-adrenoceptor) antagonist that exhibits direct vasodilatory activity. It is also classified as an antihypertensive agent.
    Formula:C20H28ClNO4S
    Color and Shape:Solid
    Molecular weight:413.96

    Ref: TM-T201759

  • Monlunabant
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    Monlunabant

    CAS:
    Monlunabant ((S)-MRI-1891), a solid dispersion compound, functions as an inhibitor of the cannabinoid CB1 receptor [1].
    Formula:C26H22ClF3N6O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:591.00

    Ref: TM-T79137