Zolmitriptan and Impurities

<p>Applications A metabolite of Zolmitriptan (Z639000).<br>References Buckingham, J., et al.: J. Med. Chem., 38, 3566 (1995),<br></p>

<p>Impurity Zolmitriptan USP Related Compound E<br>Applications A metabolite of Zolmitriptan. Zolmitriptan USP Related Compound E.<br>References Forrester, L., et al.: Biochem. J., 281, 359 (1992), Newton, D., et al.: Drug Metab. Dis., 23, 154 (1995), Dixon, R., et al.: Clin. Drug Invest., 15, 515 (1998), Whale, R., et al.: Psychopharmacology, 145, 223 (1999), Wild, M., et al.: Xenobiotica, 29, 847 (1999),<br></p>

<p>Impurity Zolmitriptan USP Related Compound F<br>Stability Hygroscopic<br>Applications (N,N-Dimethyl-1-butanamine) Zolmitriptan Dimer (Zolmitriptan USP Related Compound F) is an impurity from the synthesis of Zolmitriptan (Z639000). Zolmitriptan is a Serotonin 5HTID-receptor agonist.<br>References Glen, R.C., et al.: J. Med. Chem., 38, 3566 (1995), Seaber, E., et al.: Brit. J. Clin. Pharmacol., 41, 141 (1996), Tepper, S.J., et al.: Curr. Med. Res. Opin., 15, 254 (1999)<br></p>

<p>Zolmitriptan related compound D is a drug product that is an analytical impurity of the active ingredient, zolmitriptan. It is a synthetic compound and has been shown to be metabolized in vivo in humans. The chemical name for Zolmitriptan related compound D is 3-acetyl-5-(4-methoxyphenyl)-1H-indole-2,3-dione. This compound has been shown to have niche pharmacological properties that are not shared with other compounds in the same class, such as zolmitriptan.</p>