Aminoacids and derivatives

<p>Applications A metabolite of 5-Hydroxytryptamine, also known as Serotonin (S274990).<br>References Uutela, P. et al.: Anal. Chem., 81, 8417 (2009); Koehle, C. et al.: Biochem. Pharmacol., 69, 1397 (2005); Krishnaswamy, S. et al.: Xenobiotica, 33, 169 (2003);<br></p>

<p>Applications Desacetyl Desmethyl Lacosamide is an impurity of Lacosamide (L098500) which is a potent anticonvulsant.<br>References Lees, G., et al.: Brain Res., 612, 190 (1993), Kuo, C., et al.: Mol. Pharmacol., 51, 1077 (1997), Barton, M., et al.: Epilepsy Res., 47, 217 (2001), Beyreuther, B., et al.: Eur. J. Pharmacol., 539, 64 (2006), Beyreuther, B., et al.: CNS Drug Rev., 13, 21 (2007),<br></p>

<p>Stability Moisture Sensitive<br>Applications 3-(4-Chlorophenyl)glutaric Anhydride (cas# 53911-68-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Isotope labelled L-Serine is used in the synthesis of purines and pyrimidines as antibacterial/antifungal agents, as well as acting as a proteinogenic compound.<br>References Olivella, M. et al.: Bioorg. Med. Chem., 20, 6109 (2012);<br></p>

<p>Applications A labelled synthetic amino acid precursor of Norepinephrine (N674500). Antiparkinsonian.<br>References Bartholini, J., et al.: J. Pharmacol. Exp. Ther ., 193, 523 (1975), Kato, T., et al.: Biochem. Pharmacol., 36, 3051 (1987), Kawabata, A., et al.: Br J. Pharmacol., 111, 503 (1994),<br></p>

<p>Applications 3-O-Methylcarbidopa is an impurity of Carbidopa (C175915) with potential use as therapeutic agents to treat hypertension and Parkinson's disease.<br>References Gelber, L. et al.: J. Chrom., 257, 317 (1983); Kallwass, H. et al.: Bioorg. Med. Chem., 2, 557 (1994);<br></p>

<p>Applications Labelled Dihydrochloride salt of N1-Acetylspermidine which is an analog of Spermidine (S680400), an antineoplastic.<br>References Bergeron, R. et al.: J. Med. Chem, 40, 1475 (1997);<br></p>

<p>Applications (R)-Baclofen is the R-Enantiomer of Baclofen, a specific GABA-B receptor agonist and a muscle relaxant (1,2).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References (1) Brogden, R.N., et al.: Drugs, 8,1 (1974) (2) Song, Y., et al.: Endocrinology. en.2016-1776 (2017)<br></p>

<p>Applications A labelled metabolite of 5-Hydroxytryptamine, also known as Serotonin (S274990).<br>References Uutela, P. et al.: Anal. Chem., 81, 8417 (2009); Koehle, C. et al.: Biochem. Pharmacol., 69, 1397 (2005); Krishnaswamy, S. et al.: Xenobiotica, 33, 169 (2003);<br></p>

<p>Applications L-Kynurenine-d4 Trifluoroacetic Acid Salt is the isotope labelled analog of L-Kynurenine. L-Kynurenine is a tryptophan metabolite which is a precursor of kynurenic acid, an antagonist of N-methyl-aspartate receptor.<br>References Swartz, K., et al.: J. Neurosci., 10, 2965 (1990);, Hasegawa, H., et al.: Anal. Bioanal. Chem., 377, 886 (2003); Tsai, Y., et al.: Anal. Biochem., 319, 34 (2003); Mitsuhashi, S., et al.: Anal. Chim. Acta, 584, 315 (2007)<br></p>

<p>Applications Amino acid derivative that may be used to prepare the corresponding amino acid amide L-Tryptophanamide Hydrochloride (Cat. #T89550).<br>References Smith, E.L., et al.: J. Biol. Chem., 180, 1209 (1949),<br></p>

<p>Applications A labelled imidazole, a versatile heterocycle used in the preparation of various biologically active compounds such as the amino acid histidine and is present in many antifungal medication. It is also used extensively as a corrosion inhibitor on transition metals such as copper.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Arispe, N. et al.: Biophys. J., 95, 4879 (2008); Troesken, E.R. et al.: Endo. Res., 30, 387 (2004); Otmacic Curkovic, H. et al.: Corr. Sci., 51, 2342 (2009);<br></p>

<p>Applications cis-9-Hexadecenoylcarnitine Inner Salt is an L-carnitine metobolite which are often used to diagnose specific inherited metabolic diseases.<br>References Yang, S. et l.: J. Chrom. B., Anal. Tech. Biomed. Life Sci., 857, 251 (2007); Minkler, P. et al.: J. Chrom. B., Anal. Tech. Biomed. Life Sci. 1061, 128 (2017);<br></p>

<p>Applications Used for the counterselection of TRP1, a commonly used genetic marker in the yeast Saccharoyces Cerevisiae. An antimetabolite for the tryptophan pathway in yeast, and is toxic by virtue of its antimetabolite conversion to 5-Fluorotryptophan. It can be used for the selection of tryptophan auxotroophs.<br>References Toyn, J.H., et al.: Yeast, 16, 553, 560 (2000)<br></p>

<p>Applications A metabolite of Malatonin.<br>References Young, I., et al.: J. Clin. Endocrinol. Metab., 60, 114 (1985), Barrenetxe, J., et al.: J. Physiol. Biochem., 60, 61 (2004),<br></p>

<p>Applications 2,5-Piperazinedione, can be used as an intermediate in the preparation of various pharmaceutical and biologically active compounds. It can be used in the synthesis of dipeptide isosteres by cross-metathesis.<br>References Enholm, J.E. et al.: Tetrahedron, 68, 6920 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications 4-Ethylcatechol is one of the main phenolic off-flavour markers in French ciders.<br>References Alonso-Salces, R., et al.: Anal. Bioanal. Chem., 379, 464 (2004), Xu, Y., et al.: J. Agr. Food Chemi., 55, 3051 (2007),<br></p>