Aminoacids and derivatives

<p>Applications N-Hydroxyphthalimide is used in the synthesis of a new class of antibacterials potent against macrolide resistant bacteria. Also used in the synthesis of pyrazolidines, isoxazolidines and tetrahydrooxazines.<br>References Agouridas, C. et al.: J. Med. Chem., 41, 4080 (1998); La Londe, R. et al.: Angew. Chem. Int. Ed., 49, 598 (2010);<br></p>

<p>Stability Hygroscopic<br>Applications (R)-2-Amino-N-benzyl-3-methoxypropionamide is an impurity of Lacosamide which is a potent anticonvulsant.<br>References Letiran, A., et al.: J. Med. Chem., 45, 4762 (2002); Wadavrao, S., et al.: Synthesis, 45, 3383 (2013)<br></p>

<p>Stability Hygroscopic<br>Applications CEL and CML are two stable, nonenzymatic chemical modifications of protein lysine residues resulting from glycation and oxidation reactions.<br>References Fu, M.X., et al.: J. Biol. Chem., 271, 9982 (1996), Ahmed M.U., et al.: Biochem.J., 324, 565 (1997), Schleicher, E.D., et al.: J. Clin. Invest., 99, 457 (1997), Shibayama, R., et al.: Diabetes, 48, 1842 (1999),<br></p>

<p>Applications Isotope labelled L-Serine is used in the synthesis of purines and pyrimidines as antibacterial/antifungal agents, as well as acting as a proteinogenic compound.<br>References Olivella, M. et al.: Bioorg. Med. Chem., 20, 6109 (2012);<br></p>

<p>Applications L-Kynurenine is a tryptophan metabolite which is a precursor of kynurenic acid (K660500) and an antagonist of N-methyl-aspartate receptor.<br>References Swartz, K., et al.: J. Neurosci., 10, 2965 (1990);, Hasegawa, H., et al.: Anal. Bioanal. Chem., 377, 886 (2003); Tsai, Y., et al.: Anal. Biochem., 319, 34 (2003); Mitsuhashi, S., et al.: Anal. Chim. Acta, 584, 315 (2007)<br></p>

<p>Applications L-Kynurenine-d4 Trifluoroacetic Acid Salt is the isotope labelled analog of L-Kynurenine. L-Kynurenine is a tryptophan metabolite which is a precursor of kynurenic acid, an antagonist of N-methyl-aspartate receptor.<br>References Swartz, K., et al.: J. Neurosci., 10, 2965 (1990);, Hasegawa, H., et al.: Anal. Bioanal. Chem., 377, 886 (2003); Tsai, Y., et al.: Anal. Biochem., 319, 34 (2003); Mitsuhashi, S., et al.: Anal. Chim. Acta, 584, 315 (2007)<br></p>

<p>Applications Lacosamide is a medication used for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. Lacosamide is a potent anticonvulsant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lees, G., et al.: Brain Res., 612, 190 (1993), Kuo, C., et al.: Mol. Pharmacol., 51, 1077 (1997), Barton, M., et al.: Epilepsy Res., 47, 217 (2001), Beyreuther, B., et al.: Eur. J. Pharmacol., 539, 64 (2006), Beyreuther, B., et al.: CNS Drug Rev., 13, 21 (2007),<br></p>

<p>Stability Moisture Sensitive<br>Applications 3-(4-Chlorophenyl)glutaric Anhydride (cas# 53911-68-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Desacetyl Desmethyl Lacosamide is an impurity of Lacosamide (L098500) which is a potent anticonvulsant.<br>References Lees, G., et al.: Brain Res., 612, 190 (1993), Kuo, C., et al.: Mol. Pharmacol., 51, 1077 (1997), Barton, M., et al.: Epilepsy Res., 47, 217 (2001), Beyreuther, B., et al.: Eur. J. Pharmacol., 539, 64 (2006), Beyreuther, B., et al.: CNS Drug Rev., 13, 21 (2007),<br></p>

<p>Stability Air Sensitive, Light Sensitive<br>Applications 5-Hydroxyindole-3-acetic acid is an impurity of chlorpheniramine (C424300), an antihistaminic agent.<br>References Josko, J., et al.: Annal. Acad. Med. Siles., 66, 13, (2012); Carson, R.P., et al.: Human. Molec. Genetics., 22, 140 (2013);<br></p>

<p>Applications Glycine 6-Ethylchenodeoxycholate-d5 is the labelled version of Glycine 6-Ethylchenodeoxycholate (G625250) which can be used as reactant/reagent in synthetic preparation of bile acid analogs as FXR/TGR5 agonists.<br>References Or, Y., et al.: PCT Int. Appl., WO 2016073767 A1 20160512 (2016)<br></p>

<p>Applications Isotope labelled N-Isovalerylglycine is a useful diagnostic tool in the diagnosis of many organic acidemias and mitochondrial fatty acid β-oxidation defects. N-Isovalerylglycine is found in the urine of patients with isovaleric acidemia, an inborn error of leucine metabolism.<br>References Tanaka, K. et al.: J. Biol. Chem., 242, 2966 (1967); Bonafe, L. et al.: Mol. Gen. Metab., 69, 311 (2000);<br></p>