Aminoacids and derivatives

<p>Applications N-Methyl Lacosamide is derived from (R)-2-Amino-N-benzyl-3-methoxypropionamide (A598000), which is an impurity of Lacosamide which is a potent anticonvulsant.<br>References Letiran, A., et al.: J. Med. Chem., 45, 4762 (2002); Wadavrao, S., et al.: Synthesis, 45, 3383 (2013);<br></p>

<p>Applications Epi-Lacosamide is an impurity of Lacosamide (L098500), a medication used for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. Lacosamide is a potent anticonvulsant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Choi, D., et al.: J. Med. Chem., 39, 1907 (1996), Morieux, P., et al.: Bioorg. Med. Chem., 16, 8968 (2008),<br></p>

<p>Applications Baclofen-d4, is the labeled analogue of Baclofen (B108000), a specific GABA-B receptor agonist. Muscle relaxant (skeletal).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ahuja, S., et al.: Anal. Profiles Drug Subs., 14, 527 (1985), Brogden, R.N., et al.: Drugs, 8,1 (1974)<br></p>

<p>Applications A lipid biomarker for stable and unstable heart disease.<br>References Gaziano, J., et al.: Circulation, 96, 2520 (1997), Thomas, A., et al.: Anal. Chem., 82, 6687 (2010),<br></p>

<p>Stability Hygroscopic<br>Applications L-Carnitine-d3 Chloride is the isotope labelled analog of L-Carnitine (C184110); a vitamin (enzyme cofactor). It is an essential cofactor of fatty acid metabolism and is required for the transport of fatty acids through the inner mitochondrial membrane. Synthetized primarily in the liver and kidney with the highest concentrations found in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado.<br>References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978); Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001); Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002); Karlic, H., et al.: Nutrition, 20, 709 (2004)<br></p>

<p>Applications An important metabolite of Benzene.<br></p>

<p>Applications Iminodiacetic Acid is used as a reagent in the synthesis of poly(N-isopropylacrylamide) (PNIPAM) microgel particles for metal affinity binding of peptides.<br>References Tsai, H., et al.: Colloids Surf. B, 114, 104 (2014)<br></p>

<p>Stability Very Hygroscopic, Moisture Sensitive<br>Applications 3,4-Dihydroxyphenylglycolaldehyde (Dopegal) is the monoamine oxidase metabolite of dopamine which is toxic of in a concentrated amount and may be a target for Alzheimer or Parkinson’s therapy.<br>References Burke, W. et al.: Neurotoxical., 25, 101 (2004);<br></p>

<p>Applications Benzyl Acetate, is found naturally in many flowers, It has pleasant sweet aroma reminiscent of jasmine, and thus is used widely in perfumery industry, and also as a flavouring agent. It is also used as a solvent.<br>References Schiestl, F. P., et al.: J. Chem. Ecology, 29 (2004); Qian-qian, M., et al.: Jingxi Huagong, 30, 442 (2013);<br></p>