Aminoacids and derivatives

<p>Applications 5-Aminolevulinic Acid Hydrochloride (cas# CAS:5451-09-2) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications One of the metabolites found in the lymph fluid collected from dietary stressed rats.<br>References Ardawi, M., et al.: Biochem. J., 212, 835 (1983), Otton, R., et al.: J. Endocrinol., 174, 55 (2002), Gu, H., et al.: Anal. Chem., 79, 89 (2007),<br></p>

<p>Applications Methyl 6-aminohexanoate is used as a reagent to synthesize straight chain hydroxamates, compounds that act as inhibitors of Human Histone Deacetylase (HDAC) that have the potential to treat cancer. Methyl 6-aminohexanoate is also sometimes used as a spacer unit for peptide synthesis.<br>References Matthews, S., et al.: J. Chem. Soc. Chem. Commun., 17, 1809 (1995); Remiszewski, S., et al.: J. Med. Chem., 45, 753 (2002)<br></p>

<p>Stability Hygroscopic<br>Applications Carbocisteine Lactam is an impurity of the mucolytic agent Carbocisteine (C178760).<br>References Anonymous., et al.: Biochem. J., 219, 345 (1984); Sanger, F., et al.: Biochem. J., 59, 509 (1955); Hekman, C., et al.: J. Pharm. Biomed. Anal., 20, 763 (1999);<br></p>

<p>Applications 2-Hydroxy L-Tryptophan is a metabolic intermediate in the biosynthesis of the neurotransmitters serotonin and melatonin from Tryptophan.<br>References Southan, M.D., et al.: Med. Chem. Res., 6, 343 (1996);<br></p>

<p>Applications Labelled sym-Homospermidine (H625000). sym-Homospermidine is an analogue of Spermidine. sym-Homospermidine is used as antineoplastic.<br>References Pegg, A., et al.: Cancer Res., 48, 759 (1988), Bergeron, R., et al.: J. Med. Chem., 37, 3464 (1994), Bergeron, R., et al.: Drug Metab. Dispos., 23, 1117 (1995),<br></p>

<p>Applications Labelled Tranexamic Acid (T714505). Antifibrinolytic agent; blocks lysine binding sites of plasminogen. Hemostatic.<br>References Andersson, et al.: Scand. J. Haematol. 2, 230 (1965), Melander, B., et al.: Acta Pharmacol. Toxicol., 22, 340 (1965), Bonnar, J., et al.: Br. Med. J., 313, 579 (1996), Dunn, C.J., et al.: Drugs, 57, 1005 (1999),<br></p>

<p>Applications N-Acetyl-L-Tryptophan, is a derivative of L-Tryptophan (T947210), that can be used as competitive inhibitor to identify and characterize tryptophanases. It can also be used as an NK1 tachykinin receptor antagonist, that may help to develop a novel therapeutic intervention for the treatment of reperfusion injury in acute ischemic stroke.<br>References Turner, R. J., et al.: Neuroscience, 220, 1 (2012);<br></p>

<p>Applications A labelled imidazole, a versatile heterocycle used in the preparation of various biologically active compounds such as the amino acid histidine and is present in many antifungal medication. It is also used extensively as a corrosion inhibitor on transition metals such as copper.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Arispe, N. et al.: Biophys. J., 95, 4879 (2008); Troesken, E.R. et al.: Endo. Res., 30, 387 (2004); Otmacic Curkovic, H. et al.: Corr. Sci., 51, 2342 (2009);<br></p>

<p>Applications 6-(6-(6-Aminohexanamido)hexanamido)hexanoic Acid is used in the making of a preconjugate which serves as immunoreactive conjugate useful as a developer antigen in a competitive inhibition immunoassay for the polymorphic analyte. Also used in the efficient synthesis of a heterobifunctional coupling agent.<br>References Oh, C. S., et al.: PCT Int. Appl. (1994), WO 9416330 A1 19940721; Reddy, R. E., et al.: Bioconjug. Chem., 16, 1323 (2005)<br></p>

<p>Stability Hygroscopic, moisture sensitive<br>Applications Stearoyl L-α-Lysolecithin is an bioactive lysophosphatidylcholine derived compound found to be released by bronchial epithelial cells. Stearoyl L-α-Lysolecithin have also been utilized in the development of liposomes and michelles by drug transdermal delivery devices.<br>References Zhuge, Y., et al.: Allergy Asthma Immunol Res., 6, 66 (2014)<br></p>

<p>Applications Glycine-15N is the labelled form of Glycine (G615990). Glycine is a non-essential amino acid for human development. Glycine is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.<br>References Scott, D., et al.: J. Neurosci., 21, 3063 (2001); Laube, B., et al.: Neuropharmacology, 47, 994 (2004); Papadakis, M., et al.: J. Biol. Chem., 279, 14703 (2004); Chen, P., et al.: Mol. Pharmacol., 67, 1470 (2005); Wolosker, H., et al.: Mol. Neurobiol., 36, 152 (2007)<br></p>