Carbohydrates and glycoconjugates

<p>Applications (8S-cis)-8-Acetyl-10-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione is an tert-butyldiphenylsilyl protected degredation product of Doxorubicin (D194500), an anthracycline antibiotic related to the rhodomycins.<br>References Matsumoto, T., et al.: Chem. Pharma. Bull., 34, 4613 (1986);<br></p>

<p>Applications An iridoid glycoside that exhibits protective effects against hepatic injury and other diabetic complications associated with abnormal metabolic states and inflammation caused by oxidative stress and advanced glycation endproduct formation. A potential anti-amnesic agent.<br>References Yamabe, N. et al.: Eur. J. Pharmmacol., 648, 179 (2010); de Carman Recio, M. et al.: Planta Medica, 3, 232 (1994); Kwon, S. et al.: Eur. J. Pharmacol., 619, 44 (2009);<br></p>

<p>Stability Hygroscopic<br>Applications Labelled rac FTY720 (F805010). rac FTY720 is a sphingosine 1-phosphate receptor modular, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration.<br>References Igarashi, J., et al.: J. Biol. Chem., 275, 32363 (2000), Bandhuvula, P., et al.: J. Biol. Chem., 280, 33697 (2005),<br></p>

<p>Stability Very Hygroscopic<br>Applications A component contained in cosmetic formulation. Diesters of glycosylglycerols are active in cancer chemo-prevention.<br>References Joyard, J., et al.: Eur. J. Biochem., 199, 489 (1991), Colombo, D., et al.: Bioorg. Med. Chem. Lett., 6, 1187 (1996), Colombo, D., et al.: Bioorg. Med. Chem., 7, 1867 (1999), Colombo, D., et al.: Cancer Lett., 161, 201 (2000),<br></p>

<p>Applications Ganglioside GM1 Sodium Salt (bovine brain) is a specific receptor for cholera toxin.<br>References Fishman, P.H., et al.: J. Membr. Biol., 69, 85-97 (1982); Vlasova, I., et al.: Zh. Evol. Biokhim. Fiziol., 45, 465-471 (2009);<br></p>

<p>Applications Biotin-TEG Azide is a derivative of Biotin (B389040) that is used as a reagent in the biofunctionalization on alkylated silicon substrate surfaces using click chemistry.<br>References Qin, G., et al.: J. Am. Chem. Soc., 132, 16432 (2010);<br></p>

<p>Applications L-Xylose is used in the synthesis of L-Xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.<br>References Goodwin, N.C., et. al.: J. Med. Chem., 52, 6201 (2009)<br></p>

<p>Applications 4-(6,8-Dibromo-3(4H)-quinazolinyl)-cyclohexanol is an impurity of Ambroxol (A575900), a bronchosecretolytic drug.<br>References Jauch, R., et al.: Arzneim-Forsch., 13, 474 (1963)<br></p>

<p>Applications N-Acetyllactosamine derivatives were tested as acceptors for α1,3-L-Fucosyltransferase present in human ovarian cancer sera and ovarian tumor.<br>References Lasky, L., et al.: Science, 258, 964 (1992), Hemmerich, S., et al.: Biochemistry, 33, 4830 (1994), Clarke, J., et al.: J. Biol. Chem., 271, 10317 (1996), Komba, S., et al.: Bioorg. Med. Chem., 4, 1833 (1996), Yoshino, K., et al.: J. Med. Chem., 40, 455 (1997),<br></p>

<p>Stability Very Hygroscopic<br>Applications Labelled Plerixafor, it is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM).<br>References Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),<br></p>

<p>Stability Store Under Argon<br>Applications Shown to be a functional affinity ligand for the separation of exo-(cellobiohydrolasees) and endo-(endoglucanases) acting cellulases.<br>References Piyachomkwan, K., et al.: Carbohydrate Research, 303, 255 (1997)<br></p>

<p>Applications D-(+)-Trehalose is a disaccharide composed of two α-glucose units. D-(+)-Trehalose is used in many processed foods as well as in biopharmaceutical monoclonal antibody formulations. D-(+)-Trehalose is also used as a protein stabilizer.<br>References Bosquillon, C. et al.: J. Cont. Rel., 99, 357 (2004); Arakawa, T. et al.: Adv. Drug Deliv. Rev., 46, 307 (2001); Singh, S.K. et al.: Pharmac. Res., 28, 873 (2011);<br></p>

<p>Applications Polyhyllin VI is a natural saponin extracted from the plant, Rhizoma Paridis, and displays anti-proliferative activity in vivo. Used in the treatment of HepG2 cells for tumor mitigation.<br>References Ma, D. et al.: J. Int Med. Res., 37, 631 (2009); Yin, X. et al.: Biomed. Chrom., 27, 343 (2013); Jiang, H. et al.: Mol. Med. Rep., 9, 2265 (2014); Cheng, Z. et al.: J. Ethnopharmacol., 120, 129 (2008);<br></p>

<p>Applications p-Nitrophenyl 2-Acetamido-2-deoxy-(4-O-2-acetamido-2-deoxy-β-D-_x000D_glucopyranosyl)-α-D-galactopyranoside is a compound useful in organic synthesis.<br>References Medina, M. et al.: Cancer Res. 59,1061-1070, (1999)<br></p>

<p>Stability Hygroscopic<br>Applications Benoxaprofen Glucuronide is an antiinflammatory NSAID.<br>References Okada, K. et al.: Pharmazie., 66, 777 (2011); Dong, J. et al.: Drug Metab. Disp., 37, 2314 (2009);<br></p>

<p>Applications 1-O-n-Octyl-d17-beta-D-glucopyranoside (CAS# 129522-81-2) is a useful isotopically labeled research compound.<br></p>

<p>Impurity Erdosteine EP21506 Impurity<br>Stability Hygroscopic<br>Applications An impurity of the mucolytic Erdosteine (E596050).<br></p>

<p>Applications 5'-(Methyl-d3-thio)adenosine (CAS# 174838-38-1) is a useful isotopically labeled research compound, where it is used in synthesis reactions.<br>References Sugiyama, T., et.al., Nucleic Acids Symp.Ser., 34,13-14,(1995);<br></p>