Carbohydrates and glycoconjugates

<p>Applications 4-(6,8-Dibromo-3(4H)-quinazolinyl)-cyclohexanol is an impurity of Ambroxol (A575900), a bronchosecretolytic drug.<br>References Jauch, R., et al.: Arzneim-Forsch., 13, 474 (1963)<br></p>

<p>Applications An iridoid glycoside that exhibits protective effects against hepatic injury and other diabetic complications associated with abnormal metabolic states and inflammation caused by oxidative stress and advanced glycation endproduct formation. A potential anti-amnesic agent.<br>References Yamabe, N. et al.: Eur. J. Pharmmacol., 648, 179 (2010); de Carman Recio, M. et al.: Planta Medica, 3, 232 (1994); Kwon, S. et al.: Eur. J. Pharmacol., 619, 44 (2009);<br></p>

<p>Applications L-Xylose is used in the synthesis of L-Xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.<br>References Goodwin, N.C., et. al.: J. Med. Chem., 52, 6201 (2009)<br></p>

<p>Applications 4-O-β-D-Mannopyranosyl-D-glucopyranoside (cas# 29276-55-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 5'-(Methyl-d3-thio)adenosine (CAS# 174838-38-1) is a useful isotopically labeled research compound, where it is used in synthesis reactions.<br>References Sugiyama, T., et.al., Nucleic Acids Symp.Ser., 34,13-14,(1995);<br></p>

<p>Stability Very Hygroscopic<br>Applications Labelled Plerixafor, it is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM).<br>References Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),<br></p>

<p>Applications Protected Maltotriose.<br>References Brayer, G., et al.: Biochem., 39, 4778 (2000),<br></p>

<p>Stability Stable at RT<br>Applications D-(+)-Cellohexose Eicosaacetate (cas# 355012-91-8) is a compound useful in organic synthesis.<br></p>

<p>Stability Moisture Sensitive<br>Applications US Pat. 7033765<br></p>

<p>Applications Lactitol is listed as an excipient in some prescription drugs, such as Adderall. Lactitol is a sugar alcohol used as a replacement bulk sweetener for low calorie foods. It is also used medically as a laxative.<br>References Bolhuis, G., et al.: Drug Dev. Ind. Pharm., 35, 671 (2009); Toda, Y.: New Food Ind., 33, 21 (1991); Egger, B., et al.: Eur. J. Clin. Pharmacol., 37, 205 (1989)<br></p>

<p>Applications Methyl 4-Deoxy-4-fluoro-α-D-glucose (cas# 56926-53-5) is a compound useful in organic synthesis.<br></p>

<p>Applications (8S-cis)-8-Acetyl-10-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione is an tert-butyldiphenylsilyl protected degredation product of Doxorubicin (D194500), an anthracycline antibiotic related to the rhodomycins.<br>References Matsumoto, T., et al.: Chem. Pharma. Bull., 34, 4613 (1986);<br></p>

<p>Applications A chloropropanol which shows toxic effects.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Andersen, H., et al.: Toxicology, 136, 67 (1999), Fry, J., et al.: Food Chem. Toxicol., 37, 351 (1999), Garle, M., et al.: Xenobiotica, 29, 533 (1999),<br></p>

<p>This is a custom synthesis for a polysaccharide. The CAS number is not available. It is a complex carbohydrate that contains an oligosaccharide. This polysaccharide has been modified with methylation and glycosylation, as well as click modification. It can be fluorinated to increase the purity. It is a sugar with high purity.</p>

<p>4-Methoxyphenyl 4-O-(2,3,6-tri-O-benzyl-b-D-galactopyranosyl)-2,3,6-tri-O-benzyl-b-D-glucopyranoside is a sugar that is custom synthesized. It is fluorinated and modified with saccharides. The molecular weight of this compound is 582.06 g/mol and the CAS number for it is 15041281.</p>

<p>A mixture of sodium trigalacturonate &amp; tetragalacturonate (α-1,4 sodium galacturonotriose + α-1,4 sodium galacturonotetraose) is derived from pectin or pectic acid, by enzymatic or partial acid hydrolysis (Combo, 2012). It is used in galacturonic acid metabolism research as a substrate to identify, differentiate, and characterize endo- and exopolygalacturonase(s), and gluconase(s) (Jayani, 2005). The addition of very short fragments of homogalacturonan, tri-galacturonate, and tetra-galacturonate oligosaccharides, restore development in dark-grown, de-etiolated seedling mutants, suggesting that they are unable to generate de-methylesterified pectin fragments. A model of spatiotemporally separated photoreceptive and signal-responsive cell types has been proposed, that contains overlapping subsets of the regulatory network of light-dependent seedling development (Sinclair, 2017).</p>

<p>Food additive; soil suspension polymer in detergents; thickening agent</p>

<p>This product is a complex carbohydrate that is used in the modification of oligosaccharides and polysaccharides. It is synthesized by reacting 4-O-(a-D-galactopyranosyl)-b-D-galactopyranosyl chloride with bovine serum albumin (BSA) under acidic conditions. The product has a purity of greater than 98% and a molecular weight of approximately 3,000 Daltons.</p>

<p>NGA5FB is a custom synthesis, modification, and fluorination of a glycan. It is a monosaccharide with a methylation and click modification on the terminal glucose. This glycan is synthesized with an oligosaccharide saccharide that contains a complex carbohydrate. The CAS No. for this product is 2279-97-0.</p>