Carbohydrates and glycoconjugates

<p>NA2G1F N-glycan is a modified glycopeptide that is synthesized from the monosaccharide chitin. It has been fluorinated to render it resistant to proteolytic degradation and has been glycosylated with sialic acid residues. NA2G1F N-glycan can be used for use in click chemistry, methylation, or glycosylation. The molecular weight of this product is between 5 and 50 kDa, with a purity of &gt; 98%.</p>

<p>Varenicline N-oxide is a synthetic drug product. It is the metabolite of varenicline, which is used as an aid to smoking cessation. Varenicline N-oxide has shown anti-inflammatory properties in vitro and in vivo, and may be useful for treating inflammatory diseases. Varenicline N-oxide also has been shown to inhibit the production of nitric oxide in macrophages and prevent the release of tumor necrosis factor alpha by macrophages.</p>

<p>Intermediate in the development of anti-cancer vaccines</p>

<p>A2G1 N-glycan is a high purity, methylated, custom modified oligosaccharide with a fluorinated terminal monosaccharide. It is an oligosaccharide composed of a mixture of saccharides and is synthesized using Click chemistry to introduce the fluorination at the C-3 position. A2G1 N-glycan has been shown to be useful in various applications, such as Methylation, Custom synthesis, Click modification, CAS No., Oligosaccharide, Polysaccharide, saccharide, Carbohydrate, Fluorination, complex carbohydrate.</p>

<p>Hyaluronate biotin (HB) is a modified form of hyaluronic acid. It is produced by the methylation and glycosylation of hyaluronic acid and it has an average molecular weight of 250 kDa. HB is used in tissue engineering, cell culture, and as a contrast agent for magnetic resonance imaging. The modification of hyaluronate with biotin allows for the visualization of HB using immunofluorescence microscopy. Hyaluronate biotin is a synthetic product that can be custom-synthesized to customer specifications, such as purity level, oligosaccharide content, and monosaccharide content.</p>

<p>GalNAca1-3Galb1-4GlcNAc</p>

<p>3'-Sulfated Lewis X methyl glycoside is a synthetic, fluorinated oligosaccharide that can be used as a sugar or as an intermediate in the synthesis of complex carbohydrates. It is available for custom synthesis and modification to meet your specific needs. 3'-Sulfated Lewis X methyl glycoside is a monosaccharide that has been modified with a click reaction to attach sulfate groups. This modification allows for easier saccharide recognition and binding in the body. The CAS number for 3'-sulfated Lewis X methyl glycoside is 386264-50-2.</p>

<p>Difucosyl-para-lacto-N-hexaose I is a synthetic oligosaccharide that is used as a model for the longum subsp. of human milk oligosaccharides. The Difucosyl-para-lacto-N-hexaose I oligosaccharide was synthesized from sucrose and alpha-(1,2)-fucopyranosyl chloride, which were then reacted with para-nitrophenyl bromide (PNP). This product has been shown to inhibit the growth of respiratory pathogens in vitro by binding to c-reactive protein. It also binds to the Fc region of immunoglobulins and can act as an adjuvant for vaccines.</p>

<p>3'-N-Acetylneuraminyl-N-acetyllactosamine HSA is a carbohydrate that is synthesized by the attachment of an acetyl group to a terminal glucose residue. The product is a custom synthesis and can be used for click modification. 3'-N-Acetylneuraminyl-N-acetyllactosamine HSA has been shown to have high purity and is a complex carbohydrate. This product comes in the form of an oligosaccharide or polysaccharide, which are carbohydrates composed of many sugars. 3'-N-Acetylneuraminyl-N-acetyllactosamine HSA has been fluorinated, which may reduce its degradation in vivo.</p>

<p>Methyl-O-b-D-glucopyranosyl-(1-3)-S-b-D-glucopyranosyl-(1-4)-O-4-thio-b-D-glucopyranosyl-(1,4)-b-D-[2] glucopyranoside is a synthetic saccharide with a single modification of 4'-fluoro substitution on the O6 position. This modification provides an increased stability to acid hydrolysis. Methylation and saccharide synthesis is performed in our lab and custom modifications are available upon request.</p>

<p>Heparin derived dp14 saccharide ammonium salt is a synthetic glycosaminoglycan that is found in mammalian tissues and blood. This compound is synthesized from heparin, which is a Glycosylated, complex carbohydrate. The synthesis of this compound includes methylation, click modification (a type of chemical reaction), and fluorination. This product contains saccharides that are modified with sugar, oligosaccharides, or monosaccharides. It can be custom synthesized for your specific needs and is available in high purity.</p>

<p>4-O-Acetyl-3,6-di-O-(2,3,4,6-tetra-O-acetyl-a-D-mannopyranosyl)-D-mannopyranose is a synthetic nonreducing sugar that has been modified with an acetate group at C4 and acetyl groups at C3 and C6. This compound is a white to off white crystalline solid. It is soluble in methanol and formamide. The chemical formula of the compound is CHO.</p>

<p>3-Cyclohexylpropyl-4-O-(a-D-glucopyranosyl)-b-D-glucopyranoside is a solubilized form of epidermal growth factor (EGF) that binds to the epidermal growth factor receptor. It has been shown to stimulate epidermal growth and increase the rate of cellular proliferation in human epidermis. 3-Cyclohexylpropyl-4-O-(a-D-glucopyranosyl)-b-D-glucopyranoside may also have structural roles in mitochondrial matrix, ligand binding, and energy metabolism. Further study is needed to determine the role of this drug in these processes.</p>

<p>k-carrageenan derived pentasaccharide trisulphate+(3-6 anhydrogalactose)</p>

<p>Shortest chain oligosaccharide that can be classified as a maltodextrin. A component of liquid glucose (a commercial sweetener composed of glucose, maltose, maltotriose and maltotetrose).</p>

<p>Heparin is a polysaccharide consisting of repeating units of glucosamine and glucuronic acid that has been shown to have anti-coagulant, antithrombotic, and anti-inflammatory properties. Heparin disaccharide III-H disodium salt is a heparin disaccharide that has been modified by the addition of sodium ions. This heparin disaccharide has been shown to inhibit the proliferation of leukaemia cells in vitro, which may be due to its inhibition of DNA synthesis or cell cycle progression. The mechanism by which this heparin disaccharide inhibits cell growth is not yet known. Research into this mechanism could lead to new treatments for cancer and other diseases.</p>

<p>Agarose is a polysaccharide found in red algae, typically Gelidium and Gracilaria. It is a strictly alternating polysaccharide of α-1,3 linked D-galactose and β-1,4 linked L-3,6 anhydrogalactose with occasional sulfation at position 6 of the anhydrogalactose residue. Agaro-oligosaccharides result from cleavage at galactose residues and neoagaro-oligosaccharides from cleavage at 3,6-anhydro residues. A number of publications have suggested that agarodecaose has properties that include: anti-microbial, antiviral, prebiotic, anti-tumoral, immunomodulatory, anti-inflammatory, glucosidase inhibitory, and hepatoprotective properties.</p>

<p>Chondroitin sulphate hexasaccharide ammonium salt is a synthetic glycoconjugate that is used as a drug for the treatment of osteoarthritis and other joint diseases. It is a complex carbohydrate consisting of glucuronic acid, galactose, N-acetylgalactosamine, and sulfate residues. Chondroitin sulphate hexasaccharide ammonium salt has high purity and can be custom synthesized to your specifications. This product is methylated with an acetyl group at carbon 6. The monosaccharides are modified by glycosylation with glucose or mannose residues. Chondroitin sulphate hexasaccharide ammonium salt has been click-modified to include a carboxylic acid moiety on the primary amine group at carbon 2 and an amino group on the terminal amino group at carbon 3.</p>

<p>Lewis Y tetrasaccharide-sp-biotin is a biotinylated oligsaccharide</p>

<p>Hepta-O-acetyl-b-Lactosyl-N-Fmoc-L-threonine is a substance that can be used for the diagnosis of radiation exposure. It is a liquid that is injected into the body, where it accumulates in tissues such as bone marrow. The presence of Hepta-O-acetyl-b-Lactosyl-N-Fmoc-L-threonine in bone marrow cells can be detected using an imaging technique called balloon injury. This liquid also has synergistic effects with radiation and may be useful for the treatment of diseases such as thrombolysis.</p>