Benzimidazole and Imidazole Derivatives
Benzimidazole is a compound consisting of a benzene ring fused to an imidazole ring, a five-membered structure containing two nitrogen atoms. Benzimidazole derivatives, such as albendazole, are known for their antiparasitic and antifungal activity, used in the treatment of parasitic infections and certain parasitic diseases in animals and humans. Imidazole, on the other hand, is a five-membered structure with two nitrogen atoms found in various biologically active compounds. Imidazole derivatives, such as metronidazole, have antimicrobial and antiparasitic properties. These compounds are also used in the pharmaceutical industry for treating bacterial infections, parasitic diseases, and some fungal infections, as well as in organic chemistry as catalysts.
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Found 10351 products of "Benzimidazole and Imidazole Derivatives"
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β-Ketoglutaric Acid
CAS:<p>Stability Unstable in Solution<br>Applications β-Ketoglutaric Acid is used in the synthesis of benzodiazepine derivatives. Also used in the synthesis of orally available hepatitis C virus polymerase inhibitors.<br>References Jung, D. et al.: Synth. Comm., 29, 1941 (1999); Li, H. et al.: J. Med. Chem., 52, 1255 (2009);<br></p>Formula:C5H6O5Color and Shape:Off White PowderMolecular weight:146.0981-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid (>75%)
CAS:<p>Impurity Rabeprazole EP Impurity C<br>Applications 1-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid (>75%) (Rabeprazole EP Impurity C) is a Rabeprazole (R070500) impurity. A degradation product formed in stressed tablets of Rabeprazole sodium.<br>References Kommanaboyina, B., et al.: Drug Dev. Ind. Pharm., 25, 857 (1999), Carswel, C., et al.: Drugs, 61, 2327 (2001), Garcia, C., et al.: J. Pharm. Biomed. Anal., 46, 88 (2008),<br></p>Formula:C14H11N3O3Purity:>75%Color and Shape:NeatMolecular weight:269.264-Chloro-6-ethyl-5-fluoropyrimidine
CAS:Controlled Product<p>Applications A pyrimidine derivative used as a building block in the preparation of bio-active compounds such as broad-spectrum triazole antifungal agents.<br>References Butters, M. et al.: Org. Proc. Res. Dev., 5, 28 (2001); Tong, L. et al.: Zhong. Yao., 8, 280 (2010);<br></p>Formula:C6H6ClFN2Color and Shape:NeatMolecular weight:160.582-(2-Butyl)-4-{4-[4-(4-methyloxy-phenyl)-piperazin-1-yl]-phenyl}-2,4-dihydro-[1,2,4]-triazol-3-one
CAS:Controlled Product<p>Impurity Itraconazole EP Impurity A<br>Applications 2-(2-Butyl)-4-{4-[4-(4-methyloxy-phenyl)-piperazin-1-yl]-phenyl}-2,4-dihydro-[1,2,4]-triazol-3-one (Itraconazole EP Impurity A) is an intermediate of Itraconazole.<br></p>Formula:C23H29N5O2Color and Shape:BeigeMolecular weight:407.51PD 224378
CAS:Controlled Product<p>Stability Very Hygroscopic<br>Applications PD 224378 is a lactose conjugate degradation product of pregabalin (P704800), a GABA analogue used as an anticonvulsant.<br>References Lovdahl, M.J., et al.: J. Pharma. Biomed. Anal., 28, 917 (2002);<br></p>Formula:C20H35NO11Color and Shape:NeatMolecular weight:465.49Voriconazole-d3 N-Oxide (~90%)
CAS:Controlled ProductFormula:C16D3H11F3N5O2Purity:~90%Color and Shape:NeatMolecular weight:368.332-(Ethylthio)ethanol
CAS:Controlled Product<p>Applications 2-(Ethylthio)ethanol is used to prepare aryldihydropyrimidinones as inhibitors of fatty acid transporter FATP4.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Blackburn, C., et al.: Bioorg. Med. Chem. Lett., 16, 3504 (2006)<br></p>Formula:C4H10OSColor and Shape:NeatMolecular weight:106.194-Methyl-2-[3-[(1-methylethyl)nitrosoamino]-1-phenylpropyl]phenol
CAS:Controlled ProductFormula:C19H24N2O2Color and Shape:NeatMolecular weight:312.41Isometronidazole-D4
CAS:Controlled Product<p>Applications Isometronidazole-D4 is a labelled analogue of Isometronidazole (I821342). Isometronidazole is an impurity of Metronidazole (M338880), a chemotherapeutic agent that is used as a first line defense against Clostridium difficile (C.diff). Isometronidazole is also a hypoxic cell sensitizer in humans and mice.<br>References Hentschel, M. & Schmidt, W.: Die Pharm., 47, 221 (1992); Musher, D., et al.: Clin. Inf. Dis., 40, 1586 (2005); Rosenkranz, H. & Speck, W.: Biochem. Biophys. Res. Comm., 66, 520 (1975)<br></p>Formula:C6D4H5N3O3Color and Shape:NeatMolecular weight:175.182-[2-(2-Methyl-4-nitroimidazol-1-yl)ethoxy]ethanol
CAS:Controlled ProductFormula:C8H13N3O4Color and Shape:NeatMolecular weight:215.21Tiotropium-d6 Bromide
CAS:Controlled ProductFormula:C19H16D6BrNO4S2Color and Shape:White To PurpleMolecular weight:478.45cis-Hydroxy Solifenacin (Mixture of Diastereomers)
CAS:Controlled Product<p>Applications Solifenacin (S676700) metabolite.<br>References Naito, R., et al.: J. Med. Chem., 48, 6597 (2005), Krauwinkel, W., et al.: Int. J. Clin. Pharmacol. Ther., 43, 227 (2005),<br></p>Formula:C23H26N2O3Color and Shape:NeatMolecular weight:378.46Isopropyl Itraconazole
CAS:Controlled ProductFormula:C34H36Cl2N8O4Color and Shape:NeatMolecular weight:691.613-Isobutylglutaric Anhydride
CAS:Controlled ProductFormula:C9H14O3Color and Shape:NeatMolecular weight:170.2057N-Ethylcarbamic Acid 3-[(1S)-1-(Dimethylamino)ethyl]phenyl Ester
CAS:Controlled ProductFormula:C13H20N2O2Color and Shape:NeatMolecular weight:236.3110-Methoxy-5H-dibenz[b,f]azepine-5-carbonyl chloride
CAS:Controlled ProductFormula:C16H12ClNO2Color and Shape:NeatMolecular weight:286.0010,11-Dihydro Carbamazepine
CAS:Controlled ProductFormula:C15H14N2OColor and Shape:WhiteMolecular weight:238.282,2'-Ethylenedianiline
CAS:Controlled Product<p>Applications 2,2'-Ethylenedianiline is used as a reagent to synthesize Oxcarbazepine (O869250), a broad-specturm, second-generation anticonvulsant drug that is used to treat partial and complex partial seizures in children and adults. 2,2'-Ethylenedianiline is also used as a reagent to prepare a series of triterpines (e.g. Lupeol [L474850]), compounds that have chemopreventative activity.<br>References Asmaa, M., et al.: Pac. J. Cancer Prevent., 15, 475 (2014); Kalis, M. & Huff, N.: Clin. Ther., 23, 680 (2001); Malke, S., et al.: Pharm. Sci., 69, 211 (2007); Schmidt, D. & Elger, C.: Epil. Beh., 5, 627 (2004)<br></p>Formula:C14H16N2Color and Shape:NeatMolecular weight:212.29ent-Voriconazole
CAS:Controlled Product<p>Impurity Voriconazole EP Impurity D; Voriconazole USP Related Compound B<br>Applications ent-Voriconazole (Voriconazole USP Related Compound B; Voriconazole EP Impurity D) is the (2S,3R) enantiomer in Voriconazole (V760000) drug substance.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gage, R., et al.: J. Pharm. Biomed. Anal., 17, 1449 (1998), Owens, P., et al.: Enantiomer, 4, 79 (1999), Pehourcq, F., et al.: Biomed. Chromatogr., 18, 719 (2004), Sellers, J., et al.: J. Pharm. Biomed. Anal., 41, 1088 (2006),<br></p>Formula:C16H14F3N5OColor and Shape:NeatMolecular weight:349.31
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