Benzimidazole and Imidazole Derivatives
Benzimidazole is a compound consisting of a benzene ring fused to an imidazole ring, a five-membered structure containing two nitrogen atoms. Benzimidazole derivatives, such as albendazole, are known for their antiparasitic and antifungal activity, used in the treatment of parasitic infections and certain parasitic diseases in animals and humans. Imidazole, on the other hand, is a five-membered structure with two nitrogen atoms found in various biologically active compounds. Imidazole derivatives, such as metronidazole, have antimicrobial and antiparasitic properties. These compounds are also used in the pharmaceutical industry for treating bacterial infections, parasitic diseases, and some fungal infections, as well as in organic chemistry as catalysts.
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Found 10376 products of "Benzimidazole and Imidazole Derivatives"
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2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Hydrochloride
CAS:Controlled Product<p>Impurity Omeprazole EP Impurity XI<br>Applications 2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Hydrochloride (Omeprazole EP Impurity XI) is an intermediate in the production of the antiulcer agent Omeprazole.<br>References Roma, G., et al.: J. Med. Chem., 50, 2886 (2007), Hoffmann, S., et al.: Toxicol. Lett., 180, 9 (2008),<br></p>Formula:C9H12ClNO·ClHColor and Shape:WhiteMolecular weight:222.112-(2-Butyl)-4-{4-[4-(4-methyloxy-phenyl)-piperazin-1-yl]-phenyl}-2,4-dihydro-[1,2,4]-triazol-3-one
CAS:Controlled Product<p>Impurity Itraconazole EP Impurity A<br>Applications 2-(2-Butyl)-4-{4-[4-(4-methyloxy-phenyl)-piperazin-1-yl]-phenyl}-2,4-dihydro-[1,2,4]-triazol-3-one (Itraconazole EP Impurity A) is an intermediate of Itraconazole.<br></p>Formula:C23H29N5O2Color and Shape:BeigeMolecular weight:407.51N-Methyl Omeprazole-d3 (Mixture of isomers with the methylated nitrogens of imidazole)
CAS:Controlled Product<p>Applications Labelled Omeprazole (O635000) impurity.<br>References Allenmark, S., et al.: Anal. Biochem., 136, 293 (1984), Besancon, M., et al.: J. Biol. Chem., 272, 22438 (1997),<br></p>Formula:C18H18D3N3O3SColor and Shape:NeatMolecular weight:362.46Varenicline-d2,15N2 Dihydrochloride
CAS:Controlled Product<p>Applications Varenicline-d2,15N2 Dihydrochloride, is the labelled dihydrochloride salt of Varenicline (V098492), a nicotinic α4β2 acetylcholine receptor partial agonist. Aids in smoking cessation.<br>References Benowitz, N., et al.: Clin. Pharmacol. Ther., 44, 23 (1988), Cohen, C., et al.: J. Pharmacol. Exp. Ther., 306, 407 (2003), Tapper, A., et al.: Science, 306, 1029 (2004), Coe, J., et al.: J. Med. Chem., 48, 3474 (2005), Obach, R., et al.: Drug Metab. Disp., 34, 121 (2006),<br></p>Formula:C13H13D2Cl2N15N2Color and Shape:Light Beige SolidMolecular weight:288.184-Fluorobenzonitrile
CAS:Controlled Product<p>Applications 4-Fluorobenzonitrile is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wan, J. et al.: Org. Lett., 15, 2742 (2013); Kormos, C. et al.: J. Med. Chem., 56, 4551 (2013);<br></p>Formula:C7H4FNColor and Shape:NeatMolecular weight:121.11Varenicline Carbamoyl β-D-Glucuronide
CAS:Controlled Product<p>Applications A metabolite of Varenicline.<br>References Toide, K., et al.: Biochem. Pharmacol., 67, 1269 (2004), Coe, J., et al.: J. Med. Chem., 48, 3474 (2005), Doll, R., et al.: Br. J. Cancer, 92, 426 (2005), Obach, R., et al.: Drug Metab. Dispos., 33, 262 (2005),<br></p>Formula:C20H21N3O8Color and Shape:NeatMolecular weight:431.4rac N-Demethyl Promethazine-d3 Hydrochloride
CAS:Controlled Product<p>Applications Labelled Promethazine (P757000) impurity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Keipert, S., et al.: Pharmazie, 31, 296 (1976),<br></p>Formula:C16H16D3ClN2SColor and Shape:NeatMolecular weight:309.871-Chloro-2-(dichlorophenylmethyl)benzene
CAS:Controlled Product<p>Applications 1-Chloro-2-(dichlorophenylmethyl)benzene is an intermediate used in the preparation of 2-chlorotrityl chloride resins. 1-Chloro-2-(dichlorophenylmethyl)benzene is an impurity of the antifungal agent Clotrimazole (C587400).<br>References Li, P. et al.: Guoch. Gong. Xue., 9, 558 (2009);<br></p>Formula:C13H9Cl3Color and Shape:Light YellowMolecular weight:271.579-Acridinecarboxylic acid
CAS:Controlled Product<p>Applications 9-Acridinecarboxylic acid is used in the synthesis of short DNA-binding peptides.<br></p>Formula:C14H9NO2Color and Shape:YellowMolecular weight:223.23Isometronidazole-D4
CAS:Controlled Product<p>Applications Isometronidazole-D4 is a labelled analogue of Isometronidazole (I821342). Isometronidazole is an impurity of Metronidazole (M338880), a chemotherapeutic agent that is used as a first line defense against Clostridium difficile (C.diff). Isometronidazole is also a hypoxic cell sensitizer in humans and mice.<br>References Hentschel, M. & Schmidt, W.: Die Pharm., 47, 221 (1992); Musher, D., et al.: Clin. Inf. Dis., 40, 1586 (2005); Rosenkranz, H. & Speck, W.: Biochem. Biophys. Res. Comm., 66, 520 (1975)<br></p>Formula:C6D4H5N3O3Color and Shape:NeatMolecular weight:175.182-(Ethylthio)ethanol
CAS:Controlled Product<p>Applications 2-(Ethylthio)ethanol is used to prepare aryldihydropyrimidinones as inhibitors of fatty acid transporter FATP4.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Blackburn, C., et al.: Bioorg. Med. Chem. Lett., 16, 3504 (2006)<br></p>Formula:C4H10OSColor and Shape:NeatMolecular weight:106.191',4-Dihydroxy Midazolam
CAS:Controlled Product<p>Applications A metabolite of Midazolam (M343000).<br>References Soucek, P., et al.: Xenobiotica, 22, 83 (1992), Ghosal, A., et al.: Drug Metab. Dispos., 24, 940 (1996), Kobayashi, K., et al.: Biochem. Pharmacol., 63, 889 (2002),<br></p>Formula:C18H13ClFN3O2Color and Shape:NeatMolecular weight:357.774-Hydroxy Triazolam
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications A metabolite of Triazolam (T767380).<br>References Gall, M., et al.: J. Med. Chem., 21, 1290 (1978), Jones, H., et al.: Drug Metab. Dispos., 32, 973 (2004), Hallifax, D., et al.: Drug Metab. Dispos., 33, 1852 (2005).<br></p>Formula:C17H12Cl2N4OColor and Shape:NeatMolecular weight:359.21Noratropine Hydrochloride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications A metabolite of Atropine (A794625). Two metabolites of Atropine (apoatropine and noratropine) were found in rat urine.<br>References Xu, A., et al.: J. Pharm. Biomed. Anal., 14, 33 (1995), Cherkaoui, S., et al.: J. Pharm. Biomed. Anal., 17, 1167 (1998),<br></p>Formula:C16H21NO3·HClColor and Shape:BrownMolecular weight:311.80Voriconazole-d3 N-Oxide (~90%)
CAS:Controlled ProductFormula:C16D3H11F3N5O2Purity:~90%Color and Shape:NeatMolecular weight:368.33(R)-1-Methyl-3-pyrrolidinol
CAS:Controlled Product<p>Applications (R)-1-Methyl-3-pyrrolidinol is a useful synthetic intermediate. It is used for asymmetric synthesis of constrained (-)-S-adenosyl-L-homocysteine (SAH) analogs as DNA methyltransferase inhibitors.<br>References Isakovic, L., et al.: Bioorg. Med. Chem. Lett., 19, 2742 (2009); Gobbini, M., et al.:J. Med. Chem., 51, 4601 (2008)<br></p>Formula:C5H11NOColor and Shape:NeatMolecular weight:101.15N-Acetylethanolamine
CAS:<p>Applications N-Acetylethanolamine can be used as an antistatic agent, foam boosting agent, hair conditioning humectant, skin conditioning surfactant and viscosity controlling agent in cosmetics industry. It is a non-tacky glycerine alternative for use in skin and hair care.<br>References Hough, L., et al.: J. Chem. Soc., 7923994-3997 (1957); Auzanneau, F-I, et al.: J. Chem. Soc., 10, 2831-2834 (1990);<br></p>Formula:C4H9NO2Purity:~90%Color and Shape:NeatMolecular weight:103.12Triazolam-d3
CAS:Controlled Product<p>Applications Labelled Triazolam (T767380(M)). Triazolam in an hypnotic drug used in the short term treatment of insomnia.<br>References Lomen, P., et al.: J. Int. Med. Res., 4, 55 (1976), Allens, G.S., et al.: J. Int. Med. Res., 6, 343 (1978), Pakes, G.E., et al.: Drugs, 22, 81 (1981).<br></p>Formula:C17H9D3Cl2N4Color and Shape:NeatMolecular weight:346.23Prazepam
CAS:Controlled Product<p>Applications Prazepam, is a benzodiazepine derivative drug having anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.<br>References Shader R. I., et al.: Ciba. Found. Symp., (74), 141 (1979); Jacqmin, P., et al.: Neuropsychobiology, 19 (4), 186 (1988);<br></p>Formula:C19H17ClN2OColor and Shape:Off-WhiteMolecular weight:324.80
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