Benzimidazole and Imidazole Derivatives
Benzimidazole is a compound consisting of a benzene ring fused to an imidazole ring, a five-membered structure containing two nitrogen atoms. Benzimidazole derivatives, such as albendazole, are known for their antiparasitic and antifungal activity, used in the treatment of parasitic infections and certain parasitic diseases in animals and humans. Imidazole, on the other hand, is a five-membered structure with two nitrogen atoms found in various biologically active compounds. Imidazole derivatives, such as metronidazole, have antimicrobial and antiparasitic properties. These compounds are also used in the pharmaceutical industry for treating bacterial infections, parasitic diseases, and some fungal infections, as well as in organic chemistry as catalysts.
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Found 10376 products of "Benzimidazole and Imidazole Derivatives"
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(3S)-3-(2-Methylpropyl)-pentanedioic Acid 1-Methyl Ester
CAS:Controlled Product<p>Impurity Pregabalin Impurity 17<br>Applications (3S)-3-(2-Methylpropyl)-pentanedioic Acid 1-Methyl Ester (Pregabalin Impurity 17) is an impurity of Pregabalin (P704800), a GABA analogue used as an anticonvulsant.<br>References Taylor, C.P., at al.: Epilepsy Res., 14, 11 (1993); Field, M.J., et al.: Pain, 80, 391 (1999)<br></p>Formula:C10H18O4Color and Shape:NeatMolecular weight:202.25(2-Chlorophenyl)diphenylmethane
CAS:Controlled Product<p>Applications (2-Chlorophenyl)diphenylmethane is a triarylmethane with antiproliferative activity. (2-Chlorophenyl)diphenylmethane is an impurity of the antifungal agent Clotrimazole (C587400).<br>References Al-Qawasmeh, R.A. et al.: Bioorg. Med. Chem. Lett., 14, 347 (2004);<br></p>Formula:C19H15ClColor and Shape:NeatMolecular weight:278.78Metronidazole β-D-Glucuronide
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications A metabolite of Metronidazole.<br>References Kokwaro, G.O., et al.: Biochem. Pharmacol., 45, 1243 (1993), Sidelmann, U.G. , et al.: Xenobiotica, 26, 709 (1996),<br></p>Formula:C12H17N3O9Color and Shape:NeatMolecular weight:347.283,4-Dihydro-1-phenylisoquinoline Hydrochloride
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications 3,4-Dihydro-1-phenylisoquinoline has been shown to have anesthetic properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Moore, M.B., et. al.: J. Am. Chem. Soc., 76, 3656 (1954)<br></p>Formula:C15H13N·ClHColor and Shape:NeatMolecular weight:243.73Midazolam-d6 (1 mg/mL in Acetonitrile)
CAS:Controlled ProductFormula:C18D6H7ClFN3Color and Shape:Single SolutionMolecular weight:331.802,4-Dicyano-3-(2-methylpropyl)-pentanediamide (Mixture of Diastereomers)
CAS:Controlled Product<p>Stability Hygrscopic<br>Applications 2,4-Dicyano-3-(2-methylpropyl)-pentanediamide is an impurity of Pregabalin (P704800), a GABA (A602920) analogue used as an anticonvulsant.<br>References Hoekstra, M.S., et al.: Org. Proc. Rec. Deve., 1, 26 (1997); Lowry, O., et al.: J. Biol. Chem., 193, 265 (1951); Gerlach, M., et al.: Brain Res., 741, 142 (1996); Taylor, C.P., at al.: Epilepsy Res., 14, 11 (1993), Field, M.J., et al.: Pain, 80, 391 (1999)<br></p>Formula:C11H16N4O2Color and Shape:NeatMolecular weight:236.272-(Chloromethyl)-3,5-dimethylpyridine Hydrochloride
CAS:Controlled Product<p>Applications Intermediate in the preparation of Omeprazole metabolites<br></p>Formula:C8H10ClN·ClHColor and Shape:NeatMolecular weight:192.09Oxybutynin-d10 Hydrochloride
CAS:Controlled Product<p>Applications Oxybutynin-d10 Hydrochloride is a labeled analogue of Oxybutynin Chloride (O868525), an inhibitor of proliferation and supresses gene expression in bladder smooth muscle cells.<br>References Park, J.M., et al.: J. Urol., 162, 1110 (1999); Watson, M., et al.: Brit. J. Pharmacol., 127, 590 (1999)<br></p>Formula:C22H22D10ClNO3Color and Shape:NeatMolecular weight:404.01(S)-Aclidinium Bromide
CAS:Controlled Product<p>Applications (S)-Aclidinium Bromide is an isomer of Aclidinium Bromide (A190180) a novel long-acting antimuscarinic bronchodilator in phase II clinical trials for the treatment of chronic obstructive pulmonary disease (1,2).<br>References (1) Gupta, V. and Singh, D.: Expert Rev Respir Med. 6, 581 (2012)(2) De La Motte, S., et al.: Int. J. Clin. Pharmacol. Therap., 50,403 (2012)<br></p>Formula:C26H30BrNO4S2Color and Shape:Off-WhiteMolecular weight:564.5510-Methoxy-5H-dibenz[b,f]azepine-5-carbonyl chloride
CAS:Controlled ProductFormula:C16H12ClNO2Color and Shape:NeatMolecular weight:286.004-Desmethoxypropoxyl-4-chloro Rabeprazole Sulfide
CAS:Controlled Product<p>Applications A process impurity of Rabeprazole (R070500).<br>References Pingili, R.R., et al.: Pharmazie, 60, 814 (2005),<br></p>Formula:C14H12ClN3SColor and Shape:NeatMolecular weight:289.781-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid Sodium Salt
CAS:<p>Applications 1-(1H-Benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid is an impurity of Rabeprazole. It is also a degradation product formed in stressed tablets of Rabeprazole sodium.<br>References Kommanaboyina, B., et al.: Drug Dev. Ind. Pharm., 25, 857 (1999); Carswel, C., et al.: Drugs, 61, 2327 (2001); Garcia, C., et al.: J. Pharm. Biomed. Anal., 46, 88 (2008)<br></p>Formula:C14H10N3NaO3Color and Shape:NeatMolecular weight:291.24N-Carbamoyl Carbamazepine
CAS:Controlled Product<p>Impurity Carbamazepine EP Impurity C<br>Applications Carbamazepine (C175840) impurity.<br></p>Formula:C16H13N3O2Color and Shape:NeatMolecular weight:279.29(3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl Acetate
CAS:Controlled Product<p>Impurity Lansoprazole<br>Applications (3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl Acetate is an impurity of Lansoprazole (L175000). Lansoprazole is used as a gastric proton pump inhibitor and an antiulcerative. It May limit the severity of tuberculosis.<br>References Figgitt, D., et al.: Drugs, 60, 925 (2000); Katsuki, H., et al.: Eur. J. Clin. Pharmacol., 57, 709 (2001); Barradell, L.B., et al.: Drugs, 44, 225 (1992); Kim, K., et al.: Clin. Pharmacol. Ther., 72, 90 (2002); Niioka, T., et al.: Ther. Drug Monit., 28, 321 (2006); Chem. and Eng. News. p. 28 July 20 (2018)<br></p>Formula:C11H12F3NO3Color and Shape:NeatMolecular weight:263.2135,6-Dimethoxyindane-1,3-dione
CAS:Controlled ProductFormula:C11H10O4Color and Shape:NeatMolecular weight:206.192-Deschlorothien-3-yl Tioconazole Hydrochloride
CAS:Controlled Product<p>Applications 2-Deschloro Tioconazole Hydrochloride is an analog of Tioconazole (T444680), an antifungal that is more active than Fluconazole (F421000) or Voriconazole (V760000) against Candida glabrata mutant strains. Antifungal (topical).<br>References Jevons, S., et al.: Antimicrob. Agents Chemother., 15, 597 (1979), Clayton, Y.M., et al.: Clin. Exp. Dermatol., 7, 543 (1982), Marriott, M.S., et al.: Dermatologica, 166, 1 (1983),<br></p>Formula:C16H14Cl2N2OS·ClHColor and Shape:NeatMolecular weight:389.73Varenicline-d2,15N2 Dihydrochloride
CAS:Controlled Product<p>Applications Varenicline-d2,15N2 Dihydrochloride, is the labelled dihydrochloride salt of Varenicline (V098492), a nicotinic α4β2 acetylcholine receptor partial agonist. Aids in smoking cessation.<br>References Benowitz, N., et al.: Clin. Pharmacol. Ther., 44, 23 (1988), Cohen, C., et al.: J. Pharmacol. Exp. Ther., 306, 407 (2003), Tapper, A., et al.: Science, 306, 1029 (2004), Coe, J., et al.: J. Med. Chem., 48, 3474 (2005), Obach, R., et al.: Drug Metab. Disp., 34, 121 (2006),<br></p>Formula:C13H13D2Cl2N15N2Color and Shape:Light Beige SolidMolecular weight:288.181,3-Diethyl 2-(1-cyano-3-methylbutyl)propanedioate
CAS:Controlled ProductFormula:C13H21NO4Color and Shape:NeatMolecular weight:255.31Butyl Itraconazole
CAS:Controlled ProductFormula:C35H38Cl2N8O4Color and Shape:NeatMolecular weight:705.63
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