Benzimidazole and Imidazole Derivatives
Benzimidazole is a compound consisting of a benzene ring fused to an imidazole ring, a five-membered structure containing two nitrogen atoms. Benzimidazole derivatives, such as albendazole, are known for their antiparasitic and antifungal activity, used in the treatment of parasitic infections and certain parasitic diseases in animals and humans. Imidazole, on the other hand, is a five-membered structure with two nitrogen atoms found in various biologically active compounds. Imidazole derivatives, such as metronidazole, have antimicrobial and antiparasitic properties. These compounds are also used in the pharmaceutical industry for treating bacterial infections, parasitic diseases, and some fungal infections, as well as in organic chemistry as catalysts.
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Found 10376 products of "Benzimidazole and Imidazole Derivatives"
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N-Carbamoyl Carbamazepine
CAS:Controlled Product<p>Impurity Carbamazepine EP Impurity C<br>Applications Carbamazepine (C175840) impurity.<br></p>Formula:C16H13N3O2Color and Shape:NeatMolecular weight:279.298-Demethyl Zolazepam
CAS:Controlled Product<p>Applications N-Demethylated metabolite of the anesthetic agent, Zolazepam (Z613500).<br>References Baukema, J. et al.: Res. Comm. Chem. Pathol. Pharmacol., 10, 227 (1975);<br></p>Formula:C14H13FN4OColor and Shape:NeatMolecular weight:272.282-(2-Butyl)-4-{4-[4-(4-methyloxy-phenyl)-piperazin-1-yl]-phenyl}-2,4-dihydro-[1,2,4]-triazol-3-one
CAS:Controlled Product<p>Impurity Itraconazole EP Impurity A<br>Applications 2-(2-Butyl)-4-{4-[4-(4-methyloxy-phenyl)-piperazin-1-yl]-phenyl}-2,4-dihydro-[1,2,4]-triazol-3-one (Itraconazole EP Impurity A) is an intermediate of Itraconazole.<br></p>Formula:C23H29N5O2Color and Shape:BeigeMolecular weight:407.51(3S)-3-(2-Methylpropyl)-pentanedioic Acid 1-Methyl Ester
CAS:Controlled Product<p>Impurity Pregabalin Impurity 17<br>Applications (3S)-3-(2-Methylpropyl)-pentanedioic Acid 1-Methyl Ester (Pregabalin Impurity 17) is an impurity of Pregabalin (P704800), a GABA analogue used as an anticonvulsant.<br>References Taylor, C.P., at al.: Epilepsy Res., 14, 11 (1993); Field, M.J., et al.: Pain, 80, 391 (1999)<br></p>Formula:C10H18O4Color and Shape:NeatMolecular weight:202.25Midazolam-d6 (1 mg/mL in Acetonitrile)
CAS:Controlled ProductFormula:C18D6H7ClFN3Color and Shape:Single SolutionMolecular weight:331.80Modafinil-d5 Sulfone
CAS:Controlled Product<p>Applications A labelled metabolite of Modafinil (M482500), a central nervous system vigilance promoting agent, which possesses neuroprotective properties.<br>References Wong, Y., et al.: J. Clin. Pharmacol., 39, 281 (1999), Robertson, P., et al.: Drug Metab. Dispos., 28, 664 (2000), Roth, T., et al.: Clin. Ther., 28, 689 (2006),<br></p>Formula:C152H5H10NO3SColor and Shape:NeatMolecular weight:294.38(alphaS)-N,N,α-Trimethyl-3-(4-nitrophenoxy)benzenemethanamine
CAS:Controlled Product<p>Applications (αS)-N,N,α-Trimethyl-3-(4-nitrophenoxy)benzenemethanamine is an impurity of Rivastigmine Tartrate (R541000). Rivastigmine Tartrate is a brain selective acetylcholinesterase inhibitor.<br>References Rosler, M., et al.: Brit. Med. J., 318, 633 (1999); Enz, A., et al.: Prog. Brain Res., 98, 431 (1993)<br></p>Formula:C16H18N2O3Color and Shape:OrangeMolecular weight:286.33rac N-Demethyl Promethazine-d3 Hydrochloride
CAS:Controlled Product<p>Applications Labelled Promethazine (P757000) impurity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Keipert, S., et al.: Pharmazie, 31, 296 (1976),<br></p>Formula:C16H16D3ClN2SColor and Shape:NeatMolecular weight:309.8710-Bromo-5H-dibenzo[b,f]azepine-5-carboxamide
CAS:Controlled Product<p>Impurity Carbamazepine EP Impurity G<br>Applications 10-Bromo-5H-dibenzo[b,f]azepine-5-carboxamide is a Carbamazepine (C175840(P)) impurity, which has been used in treatment of pain associated with trigeminal neuralgia. It is an anticonvulsant, neuroprotective & neuroresearch product.<br>References Cry, T., et. al.: J. Assoc. Official Anal. Chem., 70, 836 (1987); Stenger, E.G., et al.: Med. Exp., 11, 191 (1964); Pynnonen, S., et al.: Ther. Drug Monit., 1, 409 (1979); Sidebottom, A., et al.: J. Clin. Pharm. Ther., 20, 31 (1995)<br></p>Formula:C15H11BrN2OColor and Shape:NeatMolecular weight:315.16Scopolamine Sulfate
CAS:Controlled Product<p>Applications Scopolamine Sulfate is an impurity of Scopolamine (S200000), an acetylcholine antagonist used in the treatment of motion sickness and also used as antiemetic, antispasmodic, mydriatic, preanesthetic agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Trendelenburg P., et al.: Archiv fuer Exper. Pathol. Pharmacol., 73, 118 (1914);<br></p>Formula:C17H21NO7SColor and Shape:NeatMolecular weight:383.42(S)-Aclidinium Bromide
CAS:Controlled Product<p>Applications (S)-Aclidinium Bromide is an isomer of Aclidinium Bromide (A190180) a novel long-acting antimuscarinic bronchodilator in phase II clinical trials for the treatment of chronic obstructive pulmonary disease (1,2).<br>References (1) Gupta, V. and Singh, D.: Expert Rev Respir Med. 6, 581 (2012)(2) De La Motte, S., et al.: Int. J. Clin. Pharmacol. Therap., 50,403 (2012)<br></p>Formula:C26H30BrNO4S2Color and Shape:Off-WhiteMolecular weight:564.55N-Desethyl N-Methyl rac-Rivastigmine
CAS:<p>Impurity Rivastigmin USP Related Compound B<br>Applications N-Desethyl N-Methyl rac-Rivastigmine (Rivastigmin USP Related Compound B) is an impurity in the synthesis of Rivastigmine (R541000) a brain selective acetylcholinesterase inhibitor. Nootropic.<br>References Rosler, M., et al.: Brit. Med. J., 318, 633 (1999), Enz, A., et al.: Prog. Brain Res., 98, 431 (1993),<br></p>Formula:C13H20N2O2Color and Shape:Clear ColourlessMolecular weight:236.312-(Ethylthio)ethanol
CAS:Controlled Product<p>Applications 2-(Ethylthio)ethanol is used to prepare aryldihydropyrimidinones as inhibitors of fatty acid transporter FATP4.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Blackburn, C., et al.: Bioorg. Med. Chem. Lett., 16, 3504 (2006)<br></p>Formula:C4H10OSColor and Shape:NeatMolecular weight:106.19cis-Hydroxy Solifenacin (Mixture of Diastereomers)
CAS:Controlled Product<p>Applications Solifenacin (S676700) metabolite.<br>References Naito, R., et al.: J. Med. Chem., 48, 6597 (2005), Krauwinkel, W., et al.: Int. J. Clin. Pharmacol. Ther., 43, 227 (2005),<br></p>Formula:C23H26N2O3Color and Shape:NeatMolecular weight:378.4610-Methoxy-5H-dibenz[b,f]azepine-5-carbonyl chloride
CAS:Controlled ProductFormula:C16H12ClNO2Color and Shape:NeatMolecular weight:286.002-Chlorobenzotrichloride
CAS:Controlled Product<p>Applications 2-Chlorobenzotrichloride is a chlorinated toluene with mutagenicity.<br>References Mineki, S. et al.: Mat. technol., 23, 413 (2005); Matsushita, H. et al.: Indust. Health., 17, 199 (1979);<br></p>Formula:C7H4Cl4Color and Shape:NeatMolecular weight:229.92Voriconazole-d3 N-Oxide (~90%)
CAS:Controlled ProductFormula:C16D3H11F3N5O2Purity:~90%Color and Shape:NeatMolecular weight:368.33trans-Itraconazole
CAS:Controlled Product<p>Impurity Itraconazole EP Impurity E<br>Applications trans-Itraconazole (Itraconazole EP Impurity E) is a geometrical isomer of Itraconazole (I937500). It is a COVID19-related research product.<br>References Ahn, C., et al.: J. Korean Chem. Soc., 43, 676 (1999),<br></p>Formula:C35H38Cl2N8O4Color and Shape:NeatMolecular weight:705.631,2-Bismethylenecyclohexane (~75%)
CAS:Controlled ProductFormula:C8H12Purity:~75%Color and Shape:NeatMolecular weight:108.18Isometronidazole-D4
CAS:Controlled Product<p>Applications Isometronidazole-D4 is a labelled analogue of Isometronidazole (I821342). Isometronidazole is an impurity of Metronidazole (M338880), a chemotherapeutic agent that is used as a first line defense against Clostridium difficile (C.diff). Isometronidazole is also a hypoxic cell sensitizer in humans and mice.<br>References Hentschel, M. & Schmidt, W.: Die Pharm., 47, 221 (1992); Musher, D., et al.: Clin. Inf. Dis., 40, 1586 (2005); Rosenkranz, H. & Speck, W.: Biochem. Biophys. Res. Comm., 66, 520 (1975)<br></p>Formula:C6D4H5N3O3Color and Shape:NeatMolecular weight:175.18
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