Flavonoids and Polyphenols

<p>Applications 4-Hydroxybenzophenone-d4 is an isotopic analog of 4-Hydroxybenzophenone (H829305), a metabolite of benzophenone (B204980).<br>References Stocklinski, A. et al. Life Sciences 26, 365(1980)<br></p>

<p>Applications Coumarin is a pharmaceutic aid (flavor) that is found in tonka beans, levender oil, woodruff, sweet clover.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hazleton, L., et al.: J. Pharmacol. Exp. Ther., 118, 348 (1956); Lake, B., et al.: Food Chem. Toxicol., 37, 423 (1999); Frerot, E., et al.: Flavour Fragrance J., 17, 218 (2002); Yang, Z., et al.: Food Chem., 114, 289 (2009);<br></p>

<p>Applications 7-Hydroxy Coumarin-d5 is the labeled analogue of 7-Hydroxy Coumarin (H924875), a metabolite of Coumarin that is present in many plants and is the aglucon of skimmin.<br>References Schilling, et al.: Nature, 221, 664 (1969); Indahl, S., et al.: Xenobiotica, 1, 13 (1971); Thompson, S.G., et al.: Antimicrob. Agents Chemother., 18, 264 (1980)<br></p>

<p>Stability Hygroscopic<br>Applications rac-Hesperetin 7-O-β-D-Glucuronide is a metabolite of Hesperetin (H289500), which is the main circulating metabolite involved in osteoblast differentiation.<br>References Kim, D., et al.: J. Cell Biochem., 101, 790 (2007), Brand, W., et al.: Drug Metab. Dispos., 36, 1794 (2008)<br></p>

<p>Stability Hygroscopic<br>Applications Cyanidol 3-Glucoside is a anthocyanin that is naturally occurring in various fruits, vegetable and plants. Cyanidol 3-Glucoside is known to exhibit high antioxidant capacity and neuroprotective effects by triggering mobilization of cellular free sialic acid and utilizing it as an additional biological antioxidant in brain neural cells.<br>References Damar, I., et al.: Food. Chem., 135, 2910 (2012); Kim, S.M., et al.: Life. Sci., 90, 874 (2012); Asada, T., et al.: J. Agri. Chem., 60, 10634 (2012);<br></p>

<p>Applications Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol<br>References Akiyama, T., et al.: J. Biol. Chem., 262, 5592 (1987), O'Dell, T.J., et al.: Nature, 353, 588 (1991), Aharonovits, O., et al.: Biochim Biophys. Acta, 1112, 181 (1992), Platanias, L.C., et al.: J. Biol. Chem., 267, 24053 (1992), Yoshida, H., et al.: Biochim. Biophys. Acta, 1137, 321 (1992), Uckun, F.M., et al.: Science, 267, 886 (1995)Merck Index 12th ed. 43952. Huang, R.Q.; Fang, M.J.; Dillon, G.H., Mol. Brain Res. 67: 177-183 (1999)<br></p>

<p>Applications Urolithin A is a major metabolite of ellagitannin and exhibits anti-inflammatory and antioxidant properties.<br>References Ishimoto, H., et. al.: Bioorg. Med. Chem. Lett., 21, 5901 (2011);<br></p>

<p>Applications Sulfuric Acid conjugated Genistein metabolite.<br>References Kinjo, J., et al.: Biol. Pharm. Bull., 27, 185 (2004), Tsuchihashi, R., et al.: Nat. Med., 58, 71 (2004), Bursztyka, J., et al.: Food Chem. Toxicol., 46, 939 (2008),<br></p>