Organic Phosphates and Phosphonates

Applications A major metabolite of Fenthion (FEN). It is used as organophosphorus pesticides.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Buratti, F., et al.: Toxicol. Lett., 167, 245 (2006), Buratti, F., et al.: Drug Metab. Dispos., 33, 295 (2005), Buratti, F., et al.: Toxicology, 241, 33 (2007),

Applications Fenthion Sulfone is a metabolite of the organothiophosphate insecticide Fenthion (F278000).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Oh, C., et al.: Bull Environ. Contam. Toxicol., 78, 314 (2007); Wang, W., et al.: Anal. Chim. Acta, 602, 211 (2007);

Applications A metabolite of Fenthion (FEN).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Buratti, F., et al.: Toxicol. Lett., 167, 245 (2006), Buratti, F., et al.: Drug Metab. Dispos., 33, 295 (2005), Buratti, F., et al.: Toxicology, 241, 33 (2007),

Applications 2-Pyrrolidinylphosphonic Acid, is an impurity of Alendronate (A521250), a bisphosphonate used as a bone reabsoption inhibitor.
References Wang, X.M., et al.: Clin. J. Dent. Res., 3, 26 (2000), Woo, T., et al.: Best Pract. Res. Clin. Rheumatol., 15, 469 (2001), Benford, H.L., et al.: Bone, 28, 465 (2001),

Applications 3-(Methylnitrosamino)propionitrile (MNPN) was detected for the 1st time in the saliva of betel quid chewers and is a potent carcinogen.
References Bartsch, H., et al.: Mutat. Res., 250, 103 (1991), Su, T., et al.: Drug Metab. Dispos., 24, 884 (1996), Guengerich, F., et al.: Chem. Res. Toxicol., 14, 611 (2001),

Stability Light Sensitive, Moisture Sensitive
Applications POPE is a component of E. Coli bacteria cell membrane.
References Tu, Y., et al.: Nature Nanotechnology, 8, 594 (2013).

Pravastatin lactone is a prodrug of pravastatin that is hydrolyzed in vivo to its active form. It is used for the treatment of bowel disease and has been shown to have concentration-time curves that are linear and dose-dependent. Pravastatin lactone has an acidic pH, which may be due to the presence of carboxyl groups on the molecule. This drug also inhibits the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, which is an enzyme that catalyzes the conversion of HMG CoA to mevalonate in order to produce cholesterol. Pravastatin lactone also suppresses the production of fatty acids by inhibiting their synthesis at the level of acetyl-coenzyme A (acetyl-CoA). The drug has not shown any evidence of toxicity when administered to rats at doses up to 10 mg/kg body weight per day