Quinones and Derivatives

<p>Applications A potent inhibitor of microtubule assembly.<br></p>

<p>Stability Hygroscopic<br>Applications Antibiotic substance produced by a white spore aspergilus which has been placed under the species name Aspergillus niveus. Also produced in small quantities by Penicillium citrinum.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ciegler, A., et al.: Appl. Microbiol., 26, 271 (1973), Creppy, E., et al.: Toxicol. Lett., 28, 29 (1985), DeGroene, E., et al.: Cancer Res., 56, 299 (1996),<br></p>

<p>Applications Sterigmatocystin is a carcinogenic mycotoxin that is struturally related to Aflatoxin. Sterigmatocystin has been shown to inhibit RNA synthesis in rat liver nuclei.Environmental contaminants; Food contaminants<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nel, W. et al.: Biochem. Pharmacol., 19, 957 (1970); Purchase, I.F.H. et al.: Food Cosm. Toxicol., 8, 289 (1970);<br></p>

<p>Stability Hygroscopic<br>Applications Patulin (PAT), a mycotoxin produced by certain species of Penicillium, Aspergillus, and Byssochlamys, is mainly found in ripe apple and apple products. Patulin-induced genotoxicity and modulation of glutathione in Hep G2 cells. Patulin is an antibiotic. Patulin-induced nephropathy and gastrointestinal tract malfunction have been demonstrated in several animal models. The oral LD50 value of patulin ranges between 29 and 55 mg/kg body weight in rodents and 170 mg/kg body weight in poultry. The World Health Organization considers patulin cytotoxic and established a safety level of patulin in apple juice at 50 μM. At 100-200 μM, patulin can directly increase intracellular oxidative stress in HEK293 and HL-60 cells. In 1944, this compound was tested in a clinical trial for potential antibiotic<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Scott, P., et al.: J. Agric. Food Chem., 20, 450 (1972), Aden, D., et al.: Nature, 282, 615 (1979), Surralles, J., et al.: Mutat. Res., 341, 169 (1995), Alves, I., et al.: Mutagenesis, 15, 229 (2000), Liu, B., et al.: Toxicol. Appl. Pharmacol., 191, 255 (2003), Puel, O., Galtier, P., and Oswald, I.P. Biosynthesis and toxicological effects of patulin. Toxins 2(4) 613-631 (2010). Liu, B., Wu, T., Yu, F., et al. Induction of oxidative stress response by the mycotoxin patulin in mammalian cells. Toxicol Sci 95(2) 340-347 (2007). Chalmers, I., and Clarke, M. Commentary: The 1994 patulin trial: The first properly controlled multicentre trial conducted under the aegis of the British Medical Research Council. Int J Epidemiol 32 253-260 (2004).<br></p>

<p>Applications Tetradehydropodophyllotoxin is a aryl-naphthalene lignans that was shown to exhibit anticancer activities.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hui, J., et al.: Med. Chem. Res., 21, 3994 (2012); Tian, H., et al.: Brit. J. Pharmacol., 150, 321 (2007); Ter, Harr, E., et al.: Bioorg. Med. Chem., 4, 1659 (1996);<br></p>

<p>Stability Hygroscopic<br>Applications Alternariol is an alternaria mycotoxin and genotoxin, found in common edible crops. It inhibits the activity of various DNA-topoisomerases, increasing the rate of DNA strand breaks.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Asam S et al. J Agric Food Chem. 2009 Jun 24;57(12):5152-60.Fehr M et al. Mol Nutr Food Res. 2009 Apr;53(4):441-51Vejdovszky K. et al. Toxicol Lett. 2017 Feb 5;267:45-52.<br></p>

<p>Applications Podophyllotoxin 4-O-glucoside is the glucoside derivative of Podophyllotoxin (P681000), a skin treatment for genital warts caused by some types of HPVs.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Marques, J.V., et al.: J. Biol. Chem., 288, 466 (2013); Kelly, M.G. &amp; Hartwell, J.L.; J. of the Nat'l Cancer Inst., 14, 967 (1954); Gupta, R.S.; Somatic Cell Genetics, 7, 59 (1981); Gupta, R.S.; Cancer Research, 43, 505 (1983)<br></p>

<p>Stability Very Hygroscopic<br>Applications Skin treatment for genital warts caused by some types of HPVs.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kelly, M.G. &amp; Hartwell, J.L.; J. of the Nat'l Cancer Inst., 14, 967 (1954), Gupta, R.S.; Somatic Cell Genetics, 7, 59 (1981), Gupta, R.S.; Cancer Research, 43, 505 (1983a)<br></p>