Sulfonamides and Derivatives

Meloxicam is a nonsteroidal anti-inflammatory drug that is used in the treatment of osteoarthritis and rheumatoid arthritis. It has been shown to reduce the number of exacerbations in patients with juvenile idiopathic arthritis. Meloxicam also inhibits the production of Cox-2, which is an enzyme that produces inflammation in joints. The oral route of administration allows meloxicam to be distributed through the body. This drug is not active against ankylosing spondylitis and it should not be taken by pregnant women or children under 12 years old.

2-(4-Formylphenyl)propionic acid is a racemic mixture of 2-formylphenylacetic acid and 4-formylphenylacetic acid. This compound is used in the treatment of bacterial infections and inflammation. It is an organic solution that can be injected, administered orally, or applied topically. The 2-(4-formylphenyl)propionic acid has been shown to have anti-inflammatory properties, but also has side effects such as skin irritation when it is applied topically. This drug can also cause nausea, vomiting, and diarrhea when administered orally.

This is a white crystalline compound that has been shown to be effective against glutamic acid-sensitive L-amino acid decarboxylase. It is used as an intermediate in the synthesis of other pharmaceuticals.

Methyl 2-sulfinobenzoate (MSB) is an analytical, research and development, and drug development impurity that is used as an API impurity and HPLC standard. It is a metabolite of sulfadiazine, which belongs to the family of drugs known as sulfonamides. MSB has been shown to have pharmacopoeia activity for the treatment of bacterial infections. It is a natural product found in plants, such as garlic and onion, or it can be synthesized from benzene and sulfur chloride.

2-[[4-(2-Pyridylsulfamoyl)phenyl]azo]hydroxybenzene is an impurity found in sulfasalazine. It is a metabolite that is formed by the P450 system in the liver. The metabolic process of 2-[[4-(2-Pyridylsulfamoyl)phenyl]azo]hydroxybenzene has been studied in detail and has been shown to be a major contributor to the pharmacokinetic profile of sulfasalazine. This substance also exhibits antimicrobial activity and inhibits the growth of bacteria, fungi, and viruses.

Ibuprofen EP impurity H is an impurity of ibuprofen. It is a white crystalline powder with a melting point of 182-184°C and a molecular weight of 253.3. Ibuprofen EP impurity H can be synthesized in high purity by reacting 4-bromobenzenesulfonyl chloride with 2-hydroxybenzoic acid in the presence of triethylamine. This impurity has been used as a standard for drug product analysis, pharmacopoeia standards, drug development, and metabolism studies. Ibuprofen EP impurity H can be identified by HPLC using a retention time of 17.2 minutes and an UV absorption maximum at 254 nm.

Torasemide EP Impurity C is a drug product that is used as an analytical standard in the metabolism studies of torasemide. Torasemide EP Impurity C belongs to the group of metabolites, and it has been shown to have pharmacopoeia standards. Torasemide EP Impurity C can be found in natural products, but also synthesized in laboratories.