Fatty Acids and Lypidic Derivatives

<p>Stability Hygroscopic<br>Applications An active carboxylate of Mevastatin (M340500). It is a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase with hypocholesterolemic activity. It has been shown to be effective in reducing cholesterol synthesis in vivo, and thereby in lowering cholesterol levels in blood.<br>References Endo, A. et al.: Atheroscler. Supp., 5, 39 (2004); Hosobuchi, M. et al.: J. Ferm. Bioeng., 76, 470 (1993);<br></p>

<p>Applications Labelled Choleretic produced by, and isolated from liver cells.<br>References Nomoto, M., et al.: Biol. Pharm. Bull., 32, 172 (2009), Simonsen, H., et al.: J. Agric. Food Chem., 57, 2056 (2009), Miyata, M., et al.: Drug Metab. Disposition, 37, 338 (2009),<br></p>

<p>Applications Orlistat isomer. Used in the asymmetric synthesis of Orlistat (O686500).<br>References Barbier, P., et al.: Helv. Chimica Acta, 70, 196 (1987),<br></p>

<p>Applications Has wide-spread occurrence in a number of sources, including man as a major biliary metabolite.<br>References Karavolas, H.J., et al.: J. Biol. Chem., 240, 1568 (1965), Tammer, A.R.: Biochem. J., 98, 25 (1966), Eneroth, P., et al.: J. Lipid Res., 7, 524 (1966), Sorensen, P.W., et al.: J. Gen. Physiol., 105, 569 (1995)<br></p>

<p>Applications D-Glucose is a simple sugar that is present in plants. A monosaccharide that may exist in open chain or cyclic conformation if in solution. It plays a vital role in photosynthesis and fuels the energy required for cellular respiration. D-Glucose is used in various metabolic processes including enzymic synthesis of cyclohexyl-α and β-D-glucosides. Can also be used as a diagnostic tool in detection of type 2 diabetes mellitus and potentially Huntington's disease through analysis of blood-glucose in type 1 diabetes mellitus.<br>References Wang, R., et al.: J. Mol. Catal. B. Enz., 56, 131 (2009); Springhorn, C. et al.: J. Clin. Endocrinol. Metab., 97, 4640 (2012); Hashimoto, K. et al.: J. Clin. Endocrinol. Metab., 97, 3016 (2012); Avelange, M. et al.: Plant. Phys., 94, 1157 (1990); Cramer, C. et al.: J. Chem. Soc., 115, 5745 (1993);<br></p>

<p>Impurity Rosuvastatin EP Impurity A<br>Applications S-Desmethyl-S-(2-hydroxy-2-methylpropyl) Rosuvastatin Sodium Salt (Rosuvastatin EP Impurity A) is an impurity of Rosuvastatin (R700500).<br></p>

<p>Applications 3α,12α-Dihydroxy-5β-chol-9(11)-enic Acid is used in the analysis and in the structure determination of unsaturated 5β-cholanoic acids.<br>References Kuksis, A., et al.: Lipids, 15, 770 (1980)<br></p>

<p>Applications Labelled sodium salt of L-Lactic Acid (L113500). L-Lactic Acid occurs in small quantities in the blood and muscle fluid of man and animals. The lactic acid concentration increases in muscle and blood after vigorous activity. L-(+)-Lactic acid is also present in liver, kidney, thymus gland, human amniotic fluid, and other organs and body fluids.<br>References Borsook, et al.: J. Biol. Chem., 102, 449 (1933); Brin, M., et al.: Ann. N.Y. Acad. Sci., 119, 851 (1965);<br></p>