Ethers and Derivatives

<p>Applications 1,1-Dichloro-1-(difluoromethoxy)-2,2,2-trifluoroethane is a polyhalogenated methyl ethyl ether with anesthetic properties.<br>References Sewell, J., Sear, J.: Anesth. Analg., 102, 764 (2006); Trogdon, G., et al.: J. Mol. Model., 13, 313 (2007); Abraham, M., et al.: J. Pharm. Sci., 97, 2373 (2008);<br></p>

<p>Applications 1,1,3,3,3-Pentafluoro-2-(fluoromethoxy)-1-propene is an impurity of Sevoflurane (H291050), and acts as an anaesthetic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tong, Z. et al.: Chem. Res. Toxicol., 15, 623 (2002); Iyer, R. et al.: J. Pharmacol. Exp. Ther., 283, 1544 (1997);<br></p>

<p>Applications Igepal is a nonionic surfactant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sedgqwick, M. et al.: Langmuir, 25, 5496 (2009);<br></p>

<p>Applications Nonidet P 40 Aubstitute, a nonionic, non-denaturing detergent, with many applications, such as used in in paper industry, hand cleaners, metal cleaners. It can also be used used to solubilize cerebral GABA receptors, in solubilization of proteins and lipids of the scallop gill ciliary membrane, and of membranes from breast cancer tumors.This compound is a contaminant of emerging concern (CECs).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shick, M., et al.: Non-ionic Surfactants, p.929 (1967); Stephens, R. E., J Cell Bio., 100, 1082 (1985);<br></p>

<p>Applications Isoflurane is a halogenated ether used for inhalational anesthesia. Recent studies suggest that there might be a relationship between administration of isoflurane and postoperative cognitive dysfunction (POCD).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lewis, M.C. et al.: Med. Hypoth., 68, 484 (2007); Mellon, R.D. et al.: Anesth. Analg., 104, 509 (2007);<br></p>

<p>Stability Volatile<br>Applications 1,1,1,3,3,3-Hexafluoro-2-propanol effects the native state of proteins, denaturing them as well as stabilizing the α-helical conformation of unfolded proteins and polypeptides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hirota, N. et al.: Prot. Sci., 6, 416 (1997);<br></p>

<p>Applications 2,2',4,4',5,5'-Hexabromodiphenyl Ether is a polybrominated diphenyl ether (PBDE) used as a flame retardant. One of the new POPs under the Stockholm Convention<br>References Rayne, S., et al.: Environ. Int., 32, 575 (2006); Jakobsson, K., et al.: Chemosphere, 46, 709 (2002)<br></p>

<p>Applications Tetrachloro Biphenol S is an endocrine disruptor with estrogenic activity.<br>References Zheng, S., et al.; Water Res., 132, 167 (2018); Kuruto-Niwa, R., et al.: Environ. Toxicol. Pharmacol., 19, 121 (2005)<br></p>

<p>Applications 1,2,3,4,5-Pentabromo-6-(2,3,4,5-tetrabromophenoxy)benzene is a polybrominated diphenyl ethers (PBDEs) found as a contaminant in soil.<br>References ‘t Mannetje, A., et al.: Sci. Total. Environ., 458, 399 (2013); Lee, S., et al.: Sci. Total. Environ., 443, 24 (2013);<br></p>