Pharmaceutical and Veterinary Compounds and Metabolites

<p>Galactose 1-phosphate, an intermediate substance in both galactose metabolism and nucleotide sugar processes, plays a crucial role in the biochemical pathways</p>

<p>Lantanose A is a bioactive chemical from Lantana cumara roots.</p>

<p>3α-Hydroxysteroid dehydrogenase (3α-HSD), encoded by the AKR1C4 gene, is responsible for catalyzing the transformation of 3-ketosteroids into 3α-hydroxy</p>

<p>Clopidogrel Related Compound A is a useful organic compound for research related to life sciences.</p>

<p>Asperaculane B, a fungal metabolite, inhibits P. falciparum (IC50: asexual 3 µM, transmission 7.89 µM) and is non-toxic to human cells.</p>

<p>Angiotensin I-13C6,15N (human, mouse, rat) TFA is a labeled version of Angiotensin I, using isotopes 13C and 15N, specifically targeted for human, mouse, and rat studies. This compound serves as a precursor to angiotensin II, which is formed through the cleavage by angiotensin-converting enzyme (ACE).</p>

<p>B4GALT1 (LgtB) is key in biochemical research, bonding UDP-galactose and N-acetylglucosamine to form Galβ1-4GlcNAc.</p>

<p>20-hydroxy LTB4, a LTB4 metabolite in neutrophils, is less active (~5%) but inhibits LTB4-induced degranulation, retains BLT2 affinity, non-agonist.</p>

<p>β-Cryptoxanthin is isolated from Satsuma mandarin orange with an anti-stress effect. It is an oxygenated carotenoid and an antioxidant.</p>

<p>AtGalAK, a GHMP kinase, converts d-GalA to GalA-1-P using ATP.</p>

<p>ACS activates fatty acids for lipid metabolism and the TCA cycle.</p>

<p>Lasiocarpine is a pyrrolizidine alkaloid, it has acute cytotoxicity in human and hepatic cell lines.</p>

<p>13,14-dehydro-15-cyclohexyl Carbaprostacyclin, a stable PGI2 analog, impedes ADP-induced platelet aggregation; ED50 ~40 nM in PRP, 77 nM in washed platelets.</p>

<p>Cholesteryl Linolenate is a human endogenous metabolite.</p>

<p>Cellobiosan is an anhydro sugar formed during biofuel production from the fast pyrolysis of wood.</p>

<p>Trihydroxycholestanoic acid aids cholic acid creation; high levels indicate Zellweger syndrome due to faulty PEX genes.</p>

<p>Cholesteryl arachidonate is a human endogenous metabolite.</p>

<p>N-β-Alanyldopamine hydrochloride (NBAD hydrochloride) represents the primary dopamine derivative found in haemolymph [1].</p>

<p>cGAMP is a second messenger that triggers interferon production via STING activation upon detecting cytosolic DNA.</p>

<p>(S)-Higenamine, a benzylisoquinoline precursor, forms from dopamine and 4-HPAA via NCS.</p>

<p>UDP-GlcNAc disodium is a substrate for O-GlcNAc transferase and removed by O-GlcNAcase, produced in the hexosamine pathway regulated by GFAT.</p>

<p>1-Amino-1-deoxy-D-fructose is an amino sugar causing DNA damage at pyrimidine sites, found in elevated levels in diabetics.</p>

<p>BlUSP enzyme turns Glc-1-P into UDP-Glucose, transferring uridyl from UTP and producing PPi.</p>

<p>(S)-3,4-Dihydroxybutyric acid (Li hydrate) is a urinary metabolite; higher in SSADH deficiency cases.</p>

<p>SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner (EC50: 0.3 mM).</p>

<p>5-Methoxyresorcinol (Flamenol) is a chemical intermediate.</p>

<p>Crotonyl-CoA tetrasodium is the tetrasodium salt form of Crotonyl-CoA. It serves as an intermediate in butyrate fermentation and in the metabolism of lysine and tryptophan. This compound plays a crucial role in the metabolism of fatty acids and amino acids.</p>

<p>Citrulline malate is a cpd of anti-fatigue.</p>

<p>4,12-Dimethoxy-6-(7,8-dihydroxy-7,8-dihydrostyryl)-2-pyrone is a microbial metabolism of yangonin, a major styryl lactone from Piper methysticum.</p>

<p>Protectin D1, or neuroprotectin D1 in neurons, is anti-inflammatory. 10(S),17(S)-DiHDHA, also PDX, differs in structure and inhibits neutrophils and platelets.</p>

<p>7-hydroxy Coumarin sulfate, a phase II coumarin metabolite, aids as an internal standard for GC/LC-MS metabolic analyses.</p>

<p>9-PAHPA, a fatty acid ester of hydroxy fatty acid (FAHFA), belongs to a recently identified family of endogenous lipids known for their antidiabetic and anti-</p>

<p>Palitantin is a useful organic compound for research related to life sciences. The catalog number is T125757 and the CAS number is 15265-28-8.</p>

<p>2-Methylpyrrolidine is an endogenous secondary metabolite that can be used for relevant research in the life sciences.</p>

<p>Kinetensin is a neurotensin-like peptide.</p>

<p>(S)-3,4-Dihydroxybutyric acid is a human urinary metabolite.</p>

<p>Adenosine 2',5'-diphosphate sodium is a competitive P2Y1 antagonist with non-selective antagonism at recombinant and human platelet P2X1 receptors.</p>

<p>Valinotricin is a minor fungal metabolite.</p>

<p>Acetoacetic acid(3-oxobutanoic acid) is a oxidative stress inducer, gluconeogenesis, and can be used as an indicator of in ketoacidosis.</p>

<p>SAHH, an enzyme, reversibly converts SAH into adenosine and L-homocysteine, and may predict HBV-LC outcomes.</p>

<p>C2 L-threo Ceramide is a sphingolipid that modulates cholesterol in cells and affects IL-4, cell cycle, and leukemia cell growth.</p>

<p>7β,25-Dihydroxycholesterol, an endogenous metabolite, functions as chemoattractants for immune cells that express EBI2 [1].</p>

<p>5(S)-HETE, an endogenous metabolite found in the blood, is utilized in researching Rheumatoid Arthritis, Rhinitis, and Asthma [1] [2].</p>

<p>15-deoxy-Δ-12,14-Prostaglandin J2 is a PPARγ agonist.</p>

<p>L-Tartaric acid sodium hydrate is a white plant-derived dicarboxylic acid used in food and wine, reacts with sodium bicarbonate.</p>

<p>Heptanoyl-L-carnitine is a medium-chain acylcarnitine and derivative of L-carnitine .</p>

<p>Prostaglandin F1α (PGF1α) is a lipid mediator and an endogenous metabolite of prostacyclin, regulate smooth muscle contraction.</p>

<p>Homocarnosine is an endogenous dipeptide in cerebral regions and cerebrospinal fluid.</p>

<p>N4-Acetylcytidine triphosphate is efficiently used as a substrate in T7 Polymerase-catalyzed in vitro transcription .</p>

<p>Hexasodium phytate is used potentially to treat vascular calcification and calciphylaxis.</p>

<p>(±)13-HODE cholesteryl ester was originally extracted from atherosclerotic lesions and shown to be produced by Cu2+-catalyzed oxidation of LDL.</p>

<p>8,11,14-Eicosatrienoic acid, also known as dihomo-γ-linolenic acid , is a polyunsaturated fatty acid (PUFA) produced from γ-linolenic acid by the action of</p>

<p>(±)18-HETE (18-Hydroxyeicosatetraenoic acid) is an arachidonic acid metabolite with a hydroxyl group on carbon 18, catalyzed by cytochrome P-450.</p>

<p>Cellohexaose, a cellulose-derived polymer, comprises at least two β(1-4) linked D-glucose units.</p>

<p>cis-5-Tetradecenoic acid, found in blood, helps study Long Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency.</p>

<p>Creatine riboside, a urinary metabolite, is a diagnostic and prognostic biomarker of lung cancer.</p>

<p>Nε,Nε,Nε-Trimethyllysine chloride (Lys(Me)3-OH Chloride) is a methylated derivative of the amino acid lysine and a component of histone proteins.</p>

<p>Alcohol oxidase, a key enzyme in the methanol utilization pathway, is derived from yeast peroxisomes.</p>

<p>4,7,10,13,16-Docosapentaenoic acid is an endogenous metabolite.</p>

<p>16(S)-HETE, a CYP450 byproduct of arachidonic acid, halts kidney ATPase by 60% at 2µM when angiotensin II is present.</p>

<p>Coproporphyrin I, an endogenous metabolite found in urine and blood, is utilized in researching liver disease and porphyria [1] [2] [3] [4].</p>

<p>D-Fructose 1-phosphate disodium salt, a derivative of fructose, serves as a crucial intermediate in glucose metabolism.</p>

<p>11-cis Retinal, a chromophore, binds to opsin, activating rhodopsin for vision; light triggers it to start phototransduction.</p>

<p>3-Hydroxysebacic acid, an endogenous metabolite found in urine, is utilized in the study of Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCADD) [1] [2].</p>

<p>substrate of IMP dehydrogenase (IMPDH)</p>

<p>8-iso PGA1: an isoprostane, non-COX prostanoid, minor PGE1 impurity, biological effects unstudied.</p>

<p>1,3-Diphenethylurea (N,N'-Bis(phenethyl)urea) is a marine derived natural products found in Lissoclinum patella.</p>

<p>2H-Naphth[2',1':4,5]indeno[1,2-d][1,3]dioxole derivative is a potent, lung-selective anti-inflammatory in Sprague Dawley rats.</p>

<p>Acremin F is a useful organic compound for research related to life sciences. The catalog number is T124074 and the CAS number is 863480-61-9.</p>

<p>LTC4, made by neutrophils and others via LTC4 synthase, causes smooth muscle contractions and is involved in asthma/allergic responses.</p>

<p>Aeruginosin B is a biochemical.</p>

<p>Ecdysone is a major steroid hormone in insects and herbs.</p>

<p>Eremofortin A, a metabolite, can be isolated from Penicillium roqueforti cultures [1].</p>

<p>N1-Acetylspermine, an endogenous metabolite found in urine, has applications in leukemia research [1] [2].</p>

<p>DepNA, a nitroaniline fatty acid amide, measures FAAH activity by releasing yellow dye p-nitroaniline upon exposure, detectable via spectrophotometer.</p>

<p>Coenzyme Q6, also Ubiquinone 30, is a benzoquinone lipid aiding respiration and acting as an antioxidant.</p>

<p>DFpLNH II: a reagent for life science research, usable as a biological material/organic compound.</p>

<p>Secalciferol is a Vitamin D metabolite,Secalciferol is a possibly anti-inflammatory steroid which is involved in bone ossification.</p>

<p>GOase, a type II copper enzyme from fungus, oxidizes alcohols to aldehydes and reduces O2 to H2O2.</p>

<p>Cvs 738 is the desmethyl form of CVS 1123, an orally bioavailable inhibitor of thrombin.</p>

<p>11-epi-Chaetomugilin I, from Chaetomium globosum, has cytotoxic effects against P388, HL-60, L1210 leukemia, and KB carcinoma cells.</p>

<p>Fumiquinazoline D, from A. fumigatus, inhibits Gram-positive/negative bacteria (MIC 8-16 μg/ml) and F. solani, C. albicans (MIC 32, 64 μg/ml).</p>

<p>Pyrindolol, a S. alboverticillatus metabolite, inhibits bovine β-galactosidase at 2 μg/ml in acid; not effective on other species' enzymes.</p>

<p>Tajixanthone is the fungus metabolite from Aspergillus variecolor [1] .</p>

<p>ent-Prostaglandin F2α is the enantiomer of PGF2α and is found in urine.</p>

<p>Leucine dehydrogenase from Bacillus spheroides oxidizes/reduces branched-chain amino acids and their keto analogs.</p>

<p>γ-Glu-Gly TFA, a γ-glutamyl dipeptide, is a human lipid metabolite with a structure resembling GABA (γ-aminobutyric acid).</p>

<p>Butyrolactone II is a useful organic compound for research related to life sciences. The catalog number is T124034 and the CAS number is 87414-44-6.</p>

<p>Pristanic acid, found in blood, aids in studying Alpha Methylacyl CoA Racemase Deficiency and Zellweger Syndrome.</p>

<p>Adenylosuccinic acid, orally active, is a purine ribonucleotide involved in nucleotide metabolism, may aid in DMD studies.</p>

<p>Mesembrenone is a selective the serotonin transporter (SERT) inhibitor. Mesembrenone is the main alkaloid of Sceletium tortuosum.</p>

<p>Hepaxanthin is a carotenoid.</p>

<p>L-Tryptophan (Tryptophane), an essential amino acid, is necessary for normal growth in infants and for nitrogen balance in adults.</p>

<p>5-(3'-Hydroxyphenyl)-γ-valerolactone, a metabolite resulting from the transformation of polyphenols such as (+)-catechin and (−)-epicatechin by gut microbiota,</p>

<p>N-acetyl Leukotriene E4 is an endogenous metabolite of Leukotriene E4, less active than Leukotriene E4, causing constriction of the airways.</p>

<p>γ-Glu-Phe (γ-Glutamylphenylalanine) is a γ-3 glutamyl dipeptide found in sourdough.it is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae</p>

<p>Endogenous metabolite in urine, 1-O-Hexadecyl-2-O-docosahexaenoyl-sn-glycero-3-phosphorylcholine, linked to obesity research.</p>

<p>Myristoyl coenzyme A lithium, a compound marked by lithium in its myristoylated form, plays a crucial role in the biochemical mechanism of myristoylation, essential for both viral functionalities and tumor growth in colon epithelial cells. This process is predominantly governed by N-myristoyltransferase (NMT), which exhibits increased activity in colon epithelial tumors compared to normal cells. The activity of NMT is significantly influenced by the reduction of coenzyme A (CoA), a vital regulator that enhances NMT's ability to induce myristoylation, unlike its oxidized form which impedes this process. Consequently, Myristoyl coenzyme A serves as an inhibitor to the demyristoylation activity, showcasing its potential as an anticancer and antiviral agent.</p>

<p>1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphoinositol is an intrinsic metabolite and a component of the cell membrane [1].</p>

<p>NahK phosphorylates GlcNAc/GalNAc at C1 using ATP to form GlcNAc-1P/GalNAc-1P.</p>