Pharmaceutical and Veterinary Compounds and Metabolites

<p>TDC, a PLP-dependent enzyme, removes carboxyl groups from tyrosine, producing tyramine and CO2, found in plants, insects, and microbes.</p>

Rubratoxin B is a mycotoxin that causes hypoglycemia and fatty liver and has exhibited anticancer activity.

<p>Ozolinone, an etozoline metabolite, is a loop diuretic treating hypertension and edema.</p>

<p>ESI1 is a small molecule inhibitor of epigenetic silencing. This compound induces the formation of nuclear aggregates of the key lipid metabolism regulator SREBP1/2, thereby concentrating transcription co-activators to drive lipid/cholesterol biosynthesis. Additionally, ESI1 promotes myelin regeneration in demyelination animal models and facilitates de novo myelination on regenerating CNS axons, reversing age-related cognitive decline.</p>

Phosphate acetyltransferase, an enzyme, reversibly transfers acetyl groups to CoA, aiding in acetate assimilation/dissimilation.

<p>Meproscillarin is a glycoside with high bioavailability (about 70%) and an elimination independent of renal function.</p>

<p>Larsucosterol sodium: a liver-derived cholesterol byproduct; modulates lipid synthesis, inflammation, and cell death regulation.</p>

<p>S-Adenosyl-L-methionine (Ademetionine) is an intermediate metabolite of methionine,for treatment of primary biliary cirrhosis and major depressive disorder.</p>

<p>7-Hydroxydichloromethotrexate is a methotrexate metabolite.</p>

<p>Ribulose: key in pentose metabolism, aids L-ribose isomerase study, yeast engineering, and chiral compound research.</p>

<p>Epothilone C is a polyketide natural product. It is produced through the collaborative action of a nonribosomal peptide synthetase (NRPS) and nine polyketide synthase (PKS) molecules within a multi-enzyme system. Epothilone C is utilized in tumor research.</p>

<p>NHC-triphosphate tetrasodium, a metabolite of β-d-N4-Hydroxycytidine, acts as a viral polymerase substrate affecting HCV RNA replication.</p>

<p>(S)-(+)-ochracin (8-hydroxy-3-methyl-3,4-dihydroisochromen-1-one) is a marine derived natural products found in Helicascus kanaloanus.</p>

<p>(±)16-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro.</p>

<p>10-FTHF is a donor of formyl groups in anabolism used as a substrate in formyltransferase reactions, which is important in purine biosynthesis.</p>

<p>An endogenous blood metabolite, 1-heptadecanoyl-glycerophosphocholine, researches pregnancy/sepsis.</p>

<p>Epoxide hydrolase, an enzyme responsible for catalyzing the reaction of epoxides with water to convert epoxy groups into diols, plays a crucial role in the metabolism of environmental pollutants and lipids. It is instrumental in detoxification, inflammatory responses, and regulating the health of the cardiovascular system. Additionally, Epoxide hydrolase is used in asymmetric catalytic reactions, such as the asymmetric ring-opening of epoxides, which are important for the synthesis of chiral pharmaceutical molecules.</p>

<p>5-Formylcytosine (5FC) is a rare mammalian DNA base aiding in demethylation, altering helix structure, and affecting RNA polymerase II activity.</p>

<p>Geranylgeranyl pyrophosphate: a metabolite for protein modification and diterpenoid precursor, used in cancer research.</p>

<p>Glycodeoxycholic acid monohydrate is a nuclear receptor ligand.</p>