Pharmaceutical and Veterinary Compounds and Metabolites

<p>L-Glutamic acid ammonium is an excitatory neurotransmitter.</p>

<p>L-Saccharopine is a product of the breakdown of essential amino acid Lysine.</p>

<p>Angiotensinogen (1-14), human TFA is a fragment of the renin substrate angiotensinogen. Angiotensinogen is a precursor for all angiotensin peptides.</p>

<p>NADP+ is the oxidized cofactor form of NADPH, vital for cell survival, redox balance, and signaling; synthesized from NAD+ and ATP.</p>

<p>Biotin (Vitamin B7) sodium aids in metabolism, cell growth, fatty acid synthesis, and gluconeogenesis.</p>

<p>Yokonoside is a biochemical.</p>

<p>Premarin (Estrone 3-sulfate) is an an estrogen sulfate with neuroprotective actions during traumatic brain injury.</p>

<p>[(3R)-3-Hydroxydodecanoyl]-L-carnitine is an endogenous metabolite[1].</p>

<p>Cystocholic acid is a metabolite of bile acids, possessing antimicrobial potential.</p>

<p>Aldosterone D8, a deuterium-labeled variant of Aldosterone produced in the adrenal zona glomerulosa, regulates blood pressure.</p>

<p>Allotetrahydrocortisol (5a-Tetrahydrocortisol) is a metabolite of Cortisol. Cortisol is the main glucocorticoid in human.</p>

<p>Glutarylcarnitine lithium indicates malonic aciduria, glutaric aciduria I in newborn screenings.</p>

<p>Tuftsin diacetate, Thr-Lys-Pro-Arg, activates macrophages/microglia; it's in immunoglobulin G's Fc and boosts immunity.</p>

<p>13,14-dihydro PGE1, a metabolite of PGE1, inhibits platelet aggregation and activates adenylate cyclase with IC50 of 31/21 nM and Kact 668 nM.</p>

<p>8-Isoprostaglandin F2α is a natural product for research related to life sciences. The catalog number is T37164 and the CAS number is 27415-26-5.</p>

<p>1, 4-butanediamine is an aliphatic diamine compound that can be used as an analytical reagent to assist in precise detection experiments and also as a dye intermediate to facilitate the synthesis of various functional dyes.</p>

<p>L-Palmitoylcarnitine TFA: long-chain fat metabolite that disrupts membranes in ischaemia &amp; inhibits KATP channels via Kir6.2 interaction.</p>

<p>Estriol-3-glucuronide, a natural compound found in urine, is also present in amniotic fluid during normal pregnancy [1][2].</p>

<p>Sucrose phosphorylase, a bacterial enzyme, transforms sucrose and phosphate into α-D-glucose-1-phosphate and D-fructose.</p>

<p>10-Formyldihydrofolate is a Methotrexate metabolite. It inhibits thymidylate synthetase and glycinamide ribotide transformylase.</p>

<p>L-Amino acid oxidase catalyzes the oxidative deamination of L-amino acids, which have local oxidative effects as well as potent antimicrobial effects.</p>

<p>Adefovir diphosphate 2TEA,a metabolite of Adefovir, an oral reverse transcriptase inhibitor with antiviral activity against herpes, hepatitis B, and HIV.</p>

<p>Epicoccamide is a marine fungal metabolite originally isolated from E. purpurascens.</p>

<p>Preterramide C is a fungal metabolite that has been found inA.</p>

<p>Di-O-demethylcurcumin (Bisdemethylcurcumin) is an intestinal metabolite of curcumin known for its neuroprotective properties.</p>

<p>2,8-Dihydroxyadenine causes urinary crystals, kidney stones, and helps diagnose APRT deficiency.</p>

<p>Manoyl oxide is a proposed intermediate in the biosynthesis of forskolin and other medically important labdane-type terpenoids.</p>

<p>D-Sedoheptulose-7-phosphate: Key in pentose phosphate path, carbon fixation, and compound biosynthesis.</p>

<p>Prostaglandin F2β (PGF2β) is the 9β-hydroxy stereoisomer of PGF2α.</p>

<p>18-Oxocortisol, a naturally occurring mineralocorticoid and adrenal biomarker, is produced by CYP11B2.</p>

<p>Diaphorase from anaerobic sludge catalyzes RDX biotransformation via denitrification.</p>

<p>1-Methyladenosine-d3 hydrochloride is the hydrochloride salt form of deuterium-labeled 1-Methyladenosine. This compound is a modification of RNA that serves as a biomarker for tumors, with elevated levels in the body linked to cancer development. Upon methylation, 1-Methyladenosine upregulates the expression of PPARδ, regulates cholesterol metabolism, and activates the Hedgehog signaling pathway, thereby driving the onset of liver tumors.</p>

<p>ADR-925 has the ability to protect neonatal rat cardiomyocytes from doxorubicin-induced injury.Cost-effective and quality-assured.</p>

<p>5-Aminolevulinic acid: heme synthesis intermediate, photosensitizer, antineoplastic, prodrug, treats actinic keratosis with blue light.</p>

<p>Uric Acid (Lithic acid) is an oxidation product of oxypurines. Uric Acid is the final oxidation product of purine catabolism in humans and primates.</p>

<p>(S)-Higenamine hydrobromide, S-enantiomer for benzylisoquinoline synthesis, results from dopamine and 4-HPAA condensation by NCS.</p>

<p>Secaubryenol is a 3,4-secocycloartane triterpenes isolated from Coussarea macrophylla.</p>

<p>13,14-dehydro-15-cyclohexyl Carbaprostacyclin, a stable PGI2 analog, impedes ADP-induced platelet aggregation; ED50 ~40 nM in PRP, 77 nM in washed platelets.</p>

<p>ACS activates fatty acids for lipid metabolism and the TCA cycle.</p>

<p>Sarcophine is a natural cembranoid from the Red Sea soft coral Sarcophyton glaucum.</p>

<p>9(S)-HOTrE is a plant metabolite and octadecatrienoic acid produced by the action of 5-lipoxygenase (5-LO) on α-linolenic acid.</p>

<p>(S)-Salsolidine is a MAO inhibitor with Ki 63μM; its R enantiomer is more effective, Ki 26μM.</p>

<p>Alterporriol B is a biochemical.</p>

<p>Tetranor-PGEM, the primary urinary byproduct of PGE1 and PGE2, marks PGE2 production; humans excrete 7-40 μg daily.</p>

<p>2-(2',3',4'-Trihydroxybutyl)quinoxaline is a food metabolite.</p>

<p>Dynorphin (1-8) is an opioid octapeptide from the porcine hypothalamus. It comprises the N-terminal eight residues of dynorphin.</p>

<p>Dihydrozeatin riboside is a cytokinin that can be isolated from Phaseolus vulgaris L.</p>

<p>Mevalonic acid 5-pyrophosphate (also known as 5-Diphosphomevalonic acid) tetralithium is an endogenous metabolite involved in the mevalonate pathway.</p>

<p>N1-Acetylspermine, an endogenous metabolite found in urine, has applications in leukemia research [1] [2].</p>

<p>5(S)-HpETE is a PUFA made by 5-LO from arachidonic acid, metabolized into LTA4, a key leukotriene precursor.</p>