Amino Acids (AA)

<p>Applications L-Serine (15n, 98%) (cas# 59935-32-9) is a useful research chemical.<br></p>

<p>Applications 2-Methoxyphenol-3,4,5,6-d4 (CAS# 7329-52-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-(1-Methylethyl)benzoic Acid is used in the synthesis of quinuclidine benzamides as agonists for nicotinic acetylcholine receptors. Also used in the synthesis of nifuroxazide analogues showing antimicrobial activity against methicillin-resistant Staphylococcus.<br>References Bodnar, A. et al.: J. Med. Chem., 48, 905 (2005); Masunari, A. et al.: Bioorg. Med. Chem. Lett., 15, 4229 (2007);<br></p>

<p>Applications Glycyl-L-tyrosine<br></p>

<p>Stability Light Sensitive, Volatile<br>Applications Labelled 2-Methylfuran (M305440). 2-Methylfuran is a volatile organic compound (VOCs) used as a potential non-intrusive tool for screening of lung cancer.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References McWilliams, et al.: Curr. Oncol. Rep., 4, 487 (2002), Buszewski, B., et al.: Biomed. Chromatogr., 21, 553 (2007), Ligor, T., et al.: J. Breath. Res., 1, 1 (2007),<br></p>

<p>Applications 4-Methylfluorene is a polycyclic aromatic hydrocarbon that has been found to be emitted by wastewater treatment facilities.<br>References Zhang, W., et. al.: Sci. Total Environ., 432m 396 (2012)<br></p>

<p>Applications L-Lysine L-Malate is used in the preparation of amino acid ionic liquids for use in food and medical field.<br></p>

<p>Applications Protected (S) enantiomer of the amino acid Phenylalanine.<br>References Zhu, P., et al.: Bioorg. Med. Chem. Lett., 19, 6966 (2009), Cramer, B., et al.: Bioorg. Med. Chem., 18, 343 (2010),<br></p>

<p>Applications 2-Mercapto-4-methyl-5-thiazoleacetic Acid is used as a reagent for determination of hydroxylamine using fused gold nanoparticles immobilized on sol-gel film modified gold electrode.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kannan, P., John, A.: Anal. Chim. Acta, 663, 158 (2010);<br></p>

<p>Applications DL-glutamine<br></p>

<p>Applications Substrate for TenA enzyme in the thiamin salvage pathway<br>References Jenkins, A., et al.: Nat. Chem. Biol., 3, 492 (2007), Jenkins, A., et al.: Bioorg. Chem., 36, 29 (2008),<br></p>

<p>Stability Volatile<br>Applications 2-Chloro-2-Methylpentane (cas# 4325-48-8) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications 2,3-dihydroxy-3-methylbutanoic acid (cas# 1756-18-9) is a useful research chemical.<br></p>

<p>Applications (4S)-4-Hydroxy-L-isoleucine is 4S isomer of 4-Hydroxyisoleucine, which is used as a treatment for type II diabetes.<br>References Martinez-Force, E., et al.: Biotechnol. Tech., 5, 209 (1991); Sauvaire, Y., et al.: Diabetes, 47, 206 (1998), Narender, T., et al.: Bioorg. Med. Chem. Lett., 2006, 16, 293 (2006);<br></p>

<p>Applications L-Glutamic acid 5-methyl ester is a protected form of L-Glutamic acid (G596960). L-Glutamic acid is a nonessential amino acid that is important to the mammalian central nervous system. L-Glutamic acid is also a neurotransmitter for cone photoreceptors in the human brain and is used as a treatment for patients who have liver disease accompanied by encephalopathy (a condition termed ‘hepatic coma’).<br>References Anderson, H., et al.: J. Nutr., 99, 82 (1969); Brandon, C. &amp; Lam, D.: Proc. Nat. Acad. Sci., 80, 5117 (1983); McDermott Jr, W., et al.: New Engl. J. Med., 253, 1093 (1955)<br></p>

<p>Applications 5-(2-Hydroxyethylamino)-2-methoxylaniline sulfate (cas# 83763-48-8) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications It can be degraded efficiently by the QL-degrading bacteria.<br>References Shukla, O., et al.: Microbios., 59, 47 (1989), Oh, Y; Biotechnol Bioeng 1994, 44, 533,,,<br></p>

<p>Applications Increased levels lead to hyperhomocysteinemia; a cardiovascular risk factor in prediction of coronary heart disease as well as being associated with congenital birth defects, pregnancy complications and cancer.<br>References Geisel, J. et al.: Clin. Chem. Lab. Med., 41, 1513 (2003); Geisel, J. et al.: Clin. Chem. Lab. Med., 41, 1513 (2003);<br></p>

<p>Applications Benzamide, 2,2'-dithiobis[N-methyl- (cas# 2527-58-4) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 5'-O-Methylthymidine (cas# 14504-60-0) is a useful research chemical.<br></p>

<p>Applications L-Anserine Nitrate Salt (cas# 10030-52-1) is a compound useful in organic synthesis.<br></p>

<p>Applications A major metabolite of non-essential amino acid L-Cysteine.<br>References Parsons, R.B. et al.: Neurotoxicol., 19, 599 (1998);<br></p>

<p>Applications N-[(R)-1-Carbethoxybutyl]-(S)-alanine is an intermediate in the synthesis of Perindoprilat (P287530), an angiotensin-converting enzyme (ACE) inhibitor. Antihypertensive.<br>References Pascard, C., et al.: J. Med. Chem., 34, 663 (1991)<br></p>

<p>Applications N-Methyl-N-trimethylsilylacetamide, is a powerful silylating agent for polar compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Melanie MacGregor-Ramiasa et. al; Acta biomaterialia, 56, undefined (2017-2-25)<br></p>

<p>Stability Hygroscopic<br>Applications Isotope labelled N-Acetyl-S-(2-cyanoethyl)-L-cysteine Ammonium Salt is a metabolite of Acrylonitrile (AN) and acrylamide (AM). Are commonly used in the synthesis of plastics and polymers.<br>References van Bladeren, P., et al.: Drug Metab. Dispos., 9, 246 (1981), Guengerich, F., et al.: Chem. Res. Toxicol., 4, 168 (1991),<br></p>

<p>Applications D-Homophenylalanine<br></p>

<p>Applications 4-Hydroxy-4-methylhepta-1,6-diene is a compound useful in organic synthesis.<br>References Ji, X., et al.: Xiangliao Xiangjing Huazhuangpin, 4, 6 (2011)<br></p>

<p>Stability Hygroscopic<br>Applications N-Acetyl-S-(2-cyanoethyl)-L-cysteine Ammonium Salt is a metabolite of Acrylonitrile (AN) and acrylamide (AM); and are commonly used in the synthesis of plastics and polymers.<br>References van Bladeren, P., et al.: Drug Metab. Dispos., 9, 246 (1981), Guengerich, F., et al.: Chem. Res. Toxicol., 4, 168 (1991),<br></p>

<p>Applications 2-Bromo-3-methylbutenoic Acid Methyl Ester (cas# 51263-40-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Methylpentane is used as a raw material/intermediate in organic synthesis, rubber solvent, and vegetable oil extraction solvent.<br>References Choi, D., et al.: Adv. Funct. Mater. 25, 920 (2015)<br></p>

<p>Applications D-Aspartic Acid Dimethyl Ester Hydrochloride is a useful synthetic intermediate in the synthesis of MK-7246 (M425045); a potent and selective CRTH2 antagonist for the treatment of respiratory diseases.<br>References Molinaro, C., et al.: J. Org. Chem., 77, 2299 (2012); Gervais, F.G., et al.: Mol. Pharmacol., 79, 69 (2011); Gallant, M, et al.: Bioorg. Med. Chem. Lett., 21, 288 (2011)<br></p>

<p>Applications A cysteine derivative as potential antitumor agent. (A609645)A vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate. (F680300)<br>References Paul, B., et al.: J. Med. Chem., et al.: 19, 1002 (1976), Xu, L., et al.: Mol. Pharm., 7, 1311 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010), Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010), McKay, D., et al.: Nut. J., 9 (2010),<br></p>

<p>Applications A metabolite of Acrylonitrile (ACN).<br>References Guengerich, F., et al.: Cancer Res., 41, 4925 (1981), Leonard, A., et al.: Mutation Res., 436, 263 (1999), Stadler, R., et al.: J. Agric. Food Chem., 52, 5550 (2004), Dybing, E., et al.: Food Chem. Toxicol., 43, 365 (2005), Rice, J., et al.: Mutation Res., 580, 3 (2005),<br></p>

<p>Applications Methyl(4-methylnaphthalen-1-ylmethyl)amine is a reagent in the preparation of heterocyclic compounds as enoyl-acyl carrier protein reductase FabI inhibitors and antibacterial agents.<br>References Stuetz, A., et al.: J. Med. Chem., 29, 112 (1986); Berman, J., et al.: PCT Int. Appl., 2004:515512 (2004)<br></p>

<p>Applications N-Methylsuccinimide-d3 is the isotope labelled analog of N-Methylsuccinimide (M329425); a model compound used to investigate the mechanism of enolization step by density-functional theory (DFT) calculations. N-Methylsuccinimide is a metabolite of N-methyl-2-pyrrolidone (NMP) and its presence in plasma and urine can be used as a biomarker of exposure to NMP<br>References Takahashi, O., et al.: Chem. Biodivers., 7, 1349 (2010)<br></p>

<p>Applications α-(2,3-Dimethylphenyl)-α-methyl-1H-imidazole-5-methanol is used as a reagent in the synthesis of Medetomidine (M203250); an α2-adrenergic agonist. Also a sedative and analgesic.<br>References Scheinin, M., et al.: Br. J. Clin. Pharmacol., 24, 443 (1987); Stenberg, D., et al.: J. Vet. Pharmacol. Ther., 10, 319 (1987); Virtanen, R., et al.: Eur. J. Pharmacol., 150, 9 (1988); Cullen, L.K., et al.: Br. Vet. J., 152, 519 (1996); Chen, W., et al.: Faming Zhuanli Shenqing. CN 101921234 A 20101222. Dec 22, 2010<br></p>

<p>Applications: (3,5-Di-tert-butyl-4-methoxyphenyl)boronic acid (cas# 233584-42-4) is a useful research chemical.<br></p>

<p>Applications This not naturally occurring amino acid was first observed after alkali treatment of different proteins. Synthetic Lysinoalanine was found to have a strong chelating ability for metals.<br>References Schwass, D., et al.: J. Agric. Food Chem., 32, 1377 (1984), Ahmed, M., et al.: J. Biol. Chem., 261, 8816 (1986), Wells-Knecht, K., et al.: Biochem., 34, 3702 (1995),<br></p>

<p>Stability Moisture Sensitive<br>Applications A biologically active, cell permeable, but nonphysiologic ceramide analog. It inhibits cell proliferation and induces monocytic differentiation of HL-60 cells and induces apoptosis. It stimulates protein phosphatase 2A and activates MAP Kinase2.<br>References Inoue, T., et al.: J. Biol. Chem., 284, 9566 (2009), Kang, J., et al.: Bioorg. Med. Chem., 17, 1498 (2009), Rath, G., et al.: Int. J. Biochem. Cell Biol., 41, 1165 (2009),<br></p>

<p>Applications α-Methyl-L-phenylalanine is used to prepare hippuryl-α-methylphenylalanine and hippuryl-α-methylphenyllactic acid as substrates for carboxypeptidase A. It is also used in the synthesis of high affinity tachykinin NK2 receptor antagonists.<br>References Lee, M., et al.: Bioorg. Med. Chem., 8, 815 (2000); Boyle, S., et al.: Bioorg. Med. Chem., 2, 101 (1994)<br></p>

<p>Applications 2-Chloro-1-methylquinolinium tetrafluoroborate (cas# 16843-24-6) is a useful research chemical.<br></p>

<p>Applications 8-Bromo-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dione is an intermediate used to prepare selective inhibitors of dipeptidyl peptidase 4 (DPP4) for potential use in the treatment of type 2 diabetes.<br>References Sutton, J., et al.: Bioorg. Med. Chem. Lett., 22, 1464 (2012); Lai, Z., et al.: Eur. J. Med. Chem., 83, 547 (2014)<br></p>

<p>Applications (±)-Aspartic Acid, is a non-essential amino acid found in food sources. Its conjugate base D-aspartate has potential use as a a therapeutic agent in the treatment of schizophrenia-related symptoms.<br>References Errico, F. et al.: J. Neurosci., 28, 10404 (2008); Denu, J.M. et al.: Biochem., 34, 3396 (1995); Chen, P.E. et al.: Mol. Pharmacol., 67, 1470 (2005);<br></p>

<p>Applications A labelled derivative of Dibarbituric acid.<br>References Hitchings, G.H., et al.: J. Biol. Chem., 177, 357 (1949),<br></p>

<p>Applications 4-(4-Chloro-2-methylphenoxy-d3)butyric Acid (CAS# 1219803-42-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-(3-Methoxypropoxy)-2,3-dimethylpyridin-1-ium-1-olate is used in preparation of Picolylsulfides and related drugs by using Esterification and Thioetherification as the key steps.<br>References Wang, D., et al.: Faming Zhuanli Shenqing, (2019);<br></p>

<p>Applications Carbamoyl-guanidine Amidino Urea Salt, Hydrochloride salt (cas# 926-72-7) is a compound useful in organic synthesis.<br></p>

<p>Applications Methylpropylnitrosamine is used in biological studies as human liver microsomal cytochrome P-450 enzymes which are involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.<br>References Shimada, T., et al.: Cancer Res., 48, 3218 (1989);<br></p>

<p>Applications 2-amino-3-methylbutanamide Hydrochloride is a useful research chemical for the degradation studies of antibiotic MDL 62,879 (GE2270A), and a reagent for peptide synthesis.<br>References Tavecchia, P., et al.: Tetrahedron, 51, 4867 (1995); Gazis, E., et al.: Peptides, Proc. Eur. Symp., 6th, Athens, 1963, 107 (1966)<br></p>

<p>Applications L-alloisoleucine is a stereo-isomer of L-isoleucine (I820175) and is produced as a byproduct of isoleucine via transamination.  L-allo-isoleucine has been suggested to induce epithelial β-defensin expression. In addition, L-allo-isoleucine is utilized in the biosynthesis pathway for coronamic acid.<br>References Fehlbaum, P., et al.: Proc. Natl. Acad. Sci. USA 97, 12723 (2000); Parry, R. J., et al.: J. Am. Chem. Soc. 113, 1849 (1991)<br></p>

<p>Applications This compound contains up to 25% of the two other regioisiomers.<br></p>

<p>Applications 1-Azido-2-(2-methoxyethoxy)ethane (cas# 215181-61-6) is a useful research chemical.<br></p>

<p>Applications phenyl(pyridin-4-yl)methyl 4-methyl-2-(pyrimidin-2-yl)-1,3-thiazole-5-carboxylate (cas# 1281055-79-5) is a useful research chemical.<br></p>

<p>Applications 4-Aminobutyl-d8 Guanidine is the labelled analog of the decarboxylation product of the amino acid arginine (A769500) and also an intermediate in polyamine biosynthesis.<br>References Golding, B.T., et al.: Biochem. Soc. Trans., 22, 391S (1994);<br></p>

<p>Applications 2,2-Dimethoxy-N-methylethanamine is an impurity formed in the synthetic process of Methimazole (M260300), a thiourea antithyroid agent that prevents iodine organification,<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sitar, D.S., et al.: J. Pharmacol. Exp. Ther., 184, 432 (1973), Aboul-Enein, H.Y., et al.: Anal. Profiles Drug Subs., 8, 351 (1979), Cooper, D.S., et al.: N. Engl. J. Med., 311, 1353 (1984), Atterwill, C.K., et al.: Food Chem. Toxicol., 29, 355 (1991),<br></p>

<p>Impurity Rifaximin EP Impurity A<br>Applications 2-Amino-4-methylpyridine (Rifaximin EP Impurity A) is an impurity of Rifaximin.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications An intermediate in the preparation of Ethosuximide.<br></p>

<p>Applications [2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-1-yl]acetic acid (cas# 1171565-50-6) is a useful research chemical.<br></p>

<p>Applications 2-Methyl-2-(1-Methylbutyl)-propanedioic Acid 1,3-Diethyl Ester is an intermediate in the synthesis of 2,3-Dimethyl-hexanoic Acid (D473405) which is used to prepare Mono-2,3-dimethylhexyl Phthalate (M539400), a metabolite of Dibutyl phthalate (DBP) (D429495), which is widely used in consumer products.<br>References Silva, M., et al.: Arch. Toxicol., 77, 561 (2003), Silva, M., et al.: Toxicology, 210, 123 (2005), Silva, M., et al.: J. Anal. Toxicol., 29, 819, (2005)<br></p>

<p>Applications (3R)-Tetrahydrofuran-3-yl 4-Methylbenzenesulfonate is derived from (R)-(-)-3-Hydroxytetrahydrofuran (H957760), which is a versatile chemical reactant used in the synthesis of pharmaceutical agents.<br>References Hrapchak, M., et al.: J. Labelled. Comp. Radiopharm., 57, 687 (2014);<br></p>

<p>Applications Used in the synthesis of Capsaicin analogues, useful for their anti-tumor activity.<br>References Fusco, B., et al.: Drugs, 53, 909 (1997), Buisman, G., et al.: Biotechnol. Lett., 20, 131 (1998), Kobata, K., et al.: Bios. Biotechnol. Biochem., 66, 319 (2002), Aluru, M., et al.: J. Exp. Bot., 54, 1655 (2003),; Wang, W. et al.: Gaodeng Xuexiao Huaxue Xuebao 31, 2400(2010)<br></p>