Amino Acids (AA)

<p>Applications 4-Methyl-1-[3-nitro-5-(trifluoromethyl)phenyl]-1H-imidazole, is a 4-methyl-1H-imidazole (4-MEI) derivative.<br></p>

<p>Applications N-Methyl-dl-valine, HCl<br></p>

<p>Applications Metabolite of Theophylline and Caffeine.<br>References Yu, Ch. et al.: J. Bacteriol. 191, 4624 (2009); Geraets, L. et al.: Biochem. Pharmacol. 72, 902 (2006).<br></p>

<p>Stability Light Sensitive<br>Applications α-Methacrylic acid is used in chemistry as a stabilizing agent, forming a thin capping layer on the surface of nanoparticles. α-Methacrylic acid is also used as a surfactant, so that control is maintained during nanocrystal growth. α-Methacrylic acid is also used as a chelating agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Peng, W., et al.: J. Cryst. Growth, 279, 454 (2005); Qu, S., et al.: Appl. Phys. Lett., 80, 3605 (2002); Zhao, G., et al.: Phys. C: Supercond., 468, 2317 (2008)<br></p>

<p>Applications Isotope labelled Intermediate for transsulfuration whereby a mammal transfers the sulfur of methionine via homocysteine to cysteine.<br>References Thompson, J.W., et al.: J. Biol. Chem., 266, 17011 (1991), Yoshida, Y., et al.: Microbiol., 148, 3961 (2002), Jiracek, J., et al.: J. Med. Chem., 49, 3982 (2006),<br></p>

<p>Applications 5-Amino-2-methylbenzotrifluoride is used to prepare azoles as inhibitors of VEGF receptors 1 and 2 with high intestinal permeability. It can also be used to prepare curcumin analogs conjugated with antiandrogens.<br>References Kiselyov, A., et al.: Bioorg. Med. Chem. Lett., 17, 1369 (2007); Shi, Q., et al.: Bioorg. Med. Chem., 20, 4020 (2012)<br></p>

<p>Applications Piperazine derivative used as reference material for forensic laboratories.<br>References Brady, J., et al.: Drug Dev. Res., 20, 231 (1990), Winter, J., et al.: J. Pharmacol. Exp. Ther., 262, 682 (1992), Ator, N., et al.: Eur. J. Pharmacol., 241, 237 (1993), Forster, E., et al.: Eur. J. Pharmacol., 281, 81 (1995),<br></p>

<p>Applications N-[(Benzyloxy)carbonyl]glycylglycine is a reagent in the synthesis of Glycylglycyl-L-tyrosine (G718500), which is a fungal tyrosinases and their capability to oxidize peptide-bound tyrosine residues is important in a view of applicability of tyrosinases.<br>References Bowness, J., et al.: Biochem. J., 53, 620 (1953), Cuff, M., et al.: J. Mol. Biol., 278, 855 (1998), Kubo, I., et al.: Bioorg. Med. Chem., 12, 5349 (2004),<br></p>

<p>Applications L-Alanine-d3 is the labeled analogue of L-Alanine (A481500), which is used to make in-vivo measurement of glucose and alanine metabolism in studies of patients with diabetes. L-Alanine is a non-essential amino acid for human development. L-Alanine is one of the 20 amino acids encoded by the genetic code.<br>References Bier, D.M. et al.: Diabetes, 26, 1005 (1977); Capaldo, B. et al.: J. Clin. Endocrinol. Metab., 71, 1220 (1990); Giacca, A. et al.: Diabetes, 47, 1763 (1998)<br></p>

<p>Applications Ethionine-induced inhibition of protein synthesis and lowering of ATP level in the liver.<br>References Rotig, A., et al.: Lancet, 356, 391 (2000), Forsgren, M., et al.: Biochem. J., 382, 519 (2004), Johnson, A., et al.: J. Biol. Chem., 280, 31397 (2005), Horvath, R., et al.: Neurology, 66, 253 (2006), Mollet, M., et al.: J. Clin. Invest., 117, 765 (2007),<br></p>

<p>Impurity Betahistine EP Impurity C (Free Base)<br>Applications N-Methyl-N,N-bis(2-pyridylethyl)amine is used as a reagent in the preparation of copper pyridylmethylethylenediamine dicyanamido polymeric complexes.<br>References Mautner, F.A. et al.: Inorg. Chim. Acta, 362, 4073 (2009);<br></p>

<p>Stability Hygroscopic<br>Applications CEL and CML are two stable, nonenzymatic chemical modifications of protein lysine residues resulting from glycation and oxidation reactions.<br>References Fu, M.X., et al.: J. Biol. Chem., 271, 9982 (1996), Ahmed M.U., et al.: Biochem.J., 324, 565 (1997), Schleicher, E.D., et al.: J. Clin. Invest., 99, 457 (1997), Shibayama, R., et al.: Diabetes, 48, 1842 (1999),<br></p>

<p>Applications N,N'-Di-4-pyridinyl-methanediamine is used to prepare bis(heteroaryl)-imidazolidinediones with oxalyl chloride.<br>References Ghandi, M., et al.: Synth. Comm., 37, 637 (2007)<br></p>

<p>Applications N-Boc-propargylamine is used in the preparation of triazolobenzylidene-thiazolopyrimidines which act as CDC25 phosphatase inhibitors. Also used in the synthesis of β-glucan polysaccharide analogs.<br>References Duval, R. et al.: J. Comb. Chem., 11, 947 (2009); Tanaka, H. et al.: Tetrahedron Lett., 53, 4104 (2012);<br></p>

<p>Applications L-Leucic Acid is a reagent in the synthesis of cryptophycins based macrocyclic depsipeptides which are used as tubulin inhibitors.<br>References Kumar, A., et al.: Eur. J. Med. Chem., 93, 55 (2015)<br></p>

<p>Stability Hygroscopic<br>Applications 2S,2’S,5S)-5-Hydroxy Lysinonorleucine is one of the stereoisomers of 5-Hydroxylysinonorleucine, reduced collagen cross links.<br>References Astbury, C., et al.: Br. J. Rheumatol., 33, 11 (1994), Watts, N., et al.: Clin. Chem., 45, 1359 (1999), Banse, X., et al.: Bone, 31, 70 (2002),<br></p>

<p>Applications Labelled L-Methionine, an essential aminoacid for human development. Hepatoprotectant; antidote (acetominophen poisoning); urinary acidifier.<br>References Benevenga, N.J., et al.: J. Agric. Food Chem., 22, 2 (1974), Fleisher, L.D., et al.: Clin. Endocrinol. Metab., 3, 37 (1974), Meinnel, T., et al.: Biochimie, 75, 1061 (1993),<br></p>

<p>Applications 3-N-Methyl-L-histidine is a potential compound to be used as a treatment with pharmacological PPARα agonists to stimulate the ubiquitin proteasome pathway and myofibrillar protein breakdown in skeletal muscle of rodents.<br>References Ringseis, R., et al.: Biochem. Biphys. Gen. Subject., 1830, 2105 (2013); Ubhi, B.K., et al.: Molec. Biosys., 8, 3125 (2012);<br></p>

<p>Applications Glycyl-L-Tyrosine Dihydrate is used in process for producing N-Glycyltyrosine. Glycyl-L-Tyrosine Dihydrate is the anhydrous form of Glycyl-L-tyrosine(G720108); which is used in preparation method of high quality Aspartame and Aspartame crystallization-inducing agent.<br>References Mimura, T., et al.: Eur. Pat. Appl., (1999); Gao, Z., et al.: Faming Zhuanli Shenqing, (2019);<br></p>

<p>Applications 2,6-Di-tert-butyl-4-methyl-d3-phenol (CAS# 86819-59-2) is a useful isotopically labeled research compound. This compound has been shown to significantly have lower toxic potency in mice compared to butylated hydroxytolune (BHT).<br>References Mizutani, T., et.al., Toxicol. Appl. Pharmacol. 69,283-290,(1983);<br></p>

<p>Applications 1,2,3-Trichloro-5-methylbenzene is useful in calculating 21 physical properties of organic compounds strictly from molecular structure.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jain, N., et al.: J. Pharm. Sci., 88, 852-860 (1999)<br></p>

<p>Applications 2-(6-methoxynaphthalen-2-yl)propanenitrile (cas# 86603-94-3) is a useful research chemical.<br></p>

<p>Applications 3-Methylbutyric-2,2-d2 Acid (CAS# 95927-02-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications It is used as labelled biomarker for metabolic age.<br>References Selmer, T., et al.: Eur. J. Biochem., 268, 1363 (2001), Connelly, J., et al.: Drug Metab. Dispos., 30, 1357 (2002), Lindon, J., et al.: Pharm. Res., 23, 1075 (2006), Monteagudo, E., et al.: Xenobiotica, 37, 1000 (2007),<br></p>

<p>Applications A proteinogenic amino acids involved in the biosynthesis of purines and pyrimidines. Inhibitor of serine palmitoyltransferase. A neuromodulator.<br>References Junjaud, G. et al.: J. Neurochem., 98, 1159 (2006); Hanada, K. et al.: FEBS Lett., 474, 63 (2000); Pollegionni, L. et al.: Cell. Mol. Life Sci., 67, 2387 (2010);<br></p>

<p>Applications L-Ornithine-2,3,3,4,4,5,5-d7 hydrochloride is the labelled analogue of L-Ornithine Hydrochloride (O695550), a non-essential amino acid for human development but is required intermediate in arginine biosynthesis. L-Ornithine is found in virtually all vertebrate tissues as well as incorporated into proteins, such as tyrocidine. Isolation from chicken excreta.<br>References Fattori, D., et al.: J. Med. Chem., 50, 550 (2007), Gomez-Alonso, S., et al.: J. Agric. Food Chem., 55, 608 (2007), Subramaniam, R., et al.: Bioorg. Med. Chem. Lett., 18, 3333 (2008),<br></p>

<p>Applications 1-Methoxy-2-propanol is used as a reagent in the synthesis of 2-amino-3-carboxy-4-phenylthiophenes as novel atypical protein kinase C inhibitors. Also used as a reagent in the synthesis of Metolachlor (M338700); a selective pre-emergence herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Titchenell, P.M., et al.: Bioorg. Med. Chem. Lett., 23, 3034 (2013); Zhang, H.: Nongyao Kexue Yu Guanli, 32, 26 (2011)<br></p>

<p>Impurity Rabeprazole EP Impurity G<br>Applications Used in the preparation of 2-[[(2-pyridyl)methyl]thio]-1H-benzimidazoles derivatives as anti helicobacter pylori agents.<br>References Kuehler, T. et al.: J. Med. Chem., 41, 1777 (1998)<br></p>

<p>Stability Moisture Sensitive<br>Applications 1-Acetate 4-Methanesulfonate 1,4-Butanediol is used in the facile cleavage of ethers. A Busulfan Impurity<br>References Mazur, Y., et al.: J. Org. Chem., 36, 532 (1971);<br></p>

<p>Applications 2-Chloro-3-methylaniline (cas# 29027-17-6) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Melatonin (M215000).<br>References Reiter, R.J., et al.: J. Biomed. Sci., 7, 444 (2000), Chen, Z., et al.: Am. J. Physiol, 284, 1618 (2003), Barrenetxe, J., et al.: J. Physiol. Biochem., 60, 61 (2004),<br></p>

<p>Applications Used for the synthesis of Bortezomib from L-phenylalanine via dipeptidyl boronic acid ester intermediates.<br>References Zhu, Y., et al.: J. Med. Chem., 52, 4192 (2009),<br></p>

<p>Applications N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-alloisoleucine, is a building block used in the synthesis of Ecumicin, which is a the potent anti-mycobacterial cyclic depsipeptide natural product.<br>References Hawkins, P. et al.: Organic Letters, Vol. 20, P: 1019-1022 (2018)<br></p>

<p>Applications D-Arginine is an unnatural isomer of L-Arginine (A769505), and is used to inhibit glutamate-induced nitric oxide production in rats. Derivatives of D-Arginine are used for pharmaceutical purposes, one example is 1-Deamino-8-D-arginine vasopressin, which is used to treat various bleeding disorders.<br>References Castellano, M., et al.: Neurosci. Lett., 314, 127 (2001); Kobrinsky, N., et al.: Lancet, 323, 1145 (1984); Weyrich, A., et al.: Circulation, 86, 279 (1992)<br></p>

<p>Applications 2-chloro-N-(2-ethyl-6-methylphenyl)acetamide (cas# 32428-71-0) is a useful research chemical.<br></p>

<p>Applications 2-Amino-5-chloro-3-methylbenzoic Acid is a useful research chemical for the preparation of benzoyl urea containing anthranillic acid groups with insecticidal activity.<br>References Peng, Y., et al.: Nongyao, 48, 326 (2009);<br></p>

<p>Applications N-Acetyl-S-(2,5-dimethylbenzene)-L-cysteine-d3 (cas# 1331909-07-9) is a compound useful in organic synthesis.<br>References Gonzalez-Reche, L., et al.: Arch. Toxicol., 77, 80 (2003),<br></p>

<p>Applications 2-amino-5-butyl-6-methylpyrimidin-4(3H)-one (cas# 4038-64-6) is a useful research chemical.<br></p>

<p>Stability Volatile<br>Applications N-Isopropyl-N-methylamine (cas# 4747-21-1) is a compound useful in organic synthesis.<br> E0<br></p>

<p>M02961 - H-Phe-OH</p>

<p>Applications (E)-3-Methoxy-5-styrylphenol (cas# 35302-70-6) is a useful research chemical.<br></p>

<p>Applications 3-Bromo-L-tyrosine is used in the preparation and synthesis of polyclonal antibodies that work against brominated protein related allergic responses and afflictions. Also effective in asthma control and prediction in children.<br>References Kambayashi, Y. et al.: J. Clin. Biochem., 44, 95 (2009); Wedes, S. et al.: J. Ped., 159, 248 (2011);<br></p>

<p>Applications Indole-3-acetic-L-alanine is a derivative of the phytohormone indole-3-acetic acid (I577340) used in studies for the isolation and characterization of Arabdopsis thaliana mutants.<br>References Rampey, R.A., et al.: G3 (Bethesda), 3, 131-141 (2013)<br></p>