Amino Acids (AA)

<p>Applications 3-(2-Methoxy-5-methylphenyl)-3-phenyl-propanoic Acid (cas# 109089-77-2) is a compound useful in organic synthesis.<br></p>

<p>Applications Isopropyl 2-bromo-2-methylpropanoate (cas# 51368-55-9) is a useful research chemical.<br></p>

<p>Applications A substrate for pyroglutamate aminopeptidase. Used for colorimetric determination of pyrrolidonyl peptidase activity in bacteria.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Szewczuk, A., et al.: Eur. J. Biochem., 8, 63 (1969), Szewczuk, A., et al.: Anal. Biochem., 39, 268 (1971)<br></p>

<p>Applications 5-Bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine is a reagent in the synthesis and structure-activity relationship studies of highly potent novel benzoxazinyl-oxazolidinone which is an antibacterial agent. Benzoxazinyl-oxazolidinone had potent activity against Gram-positive pathogens. 5-Bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine is also an intermediate in the synthesis of Tedizolid (T013750).<br>References Xin, Q., et al.: J. Med. Chem., 54, 7493 (2011)<br></p>

<p>Applications It is used as labelled biomarker for metabolic age.<br>References Selmer, T., et al.: Eur. J. Biochem., 268, 1363 (2001), Connelly, J., et al.: Drug Metab. Dispos., 30, 1357 (2002), Lindon, J., et al.: Pharm. Res., 23, 1075 (2006), Monteagudo, E., et al.: Xenobiotica, 37, 1000 (2007),<br></p>

<p>Applications 4-Methoxy-6-(trifluoromethyl)-1,3,5-triazin-2-amine can be used as reactant/reagent in preparation of N-phenylsulfony-N'-pyrimidinylureas as herbicides.<br>References Hamprecht, G., et al.: Ger. Offen., DE 4322726 A1 19950112 (1995)<br></p>

<p>Impurity Levodopa EP Impurity A; Levodopa USP Related Compound A<br>Stability Hygroscopic<br>Applications 6-Hydroxy-L-DOPA (Levodopa EP Impurity A; Levodopa USP Related Compound A) is the 6-hydroxy derivative of the amino acid L-DOPA (D533751) with neurotoxic properties. Studies show that exogenously administered 6-Hydroxy-L-DOPA is biotransformed by amino acid decarboxylase to the highly potent and catecholamine-selective neurotoxin, 6-Hydroxydopamine. The treatment of 6-Hydroxy-L-DOPA in rats resulted in the stimulation of acetylcholinesterase.<br>References Jaim-Etcheverry, G. et al.: Brain Res., 100, 699 (1975); Kostrzewa, R.M. et al.: Amino Acids, 14, 175 (1998); Berthet, A. et al.: J. Neurosci., 29, 4829 (2009);<br></p>

<p>Applications L-Tryptophan-d3 is a deuterium labelled amino acid, which is a protein building block. The unlabelled L-Tryptophan (T947210) is also available.<br>References Goze, C., et al.: Eur. J. Pharmacol., 643, 153 (2010), Bhandare, P., et al.: J. Chem. Pharm. Res., 2, 372 (2010),<br></p>

<p>Stability Temperature Sensitive<br>Applications Precursor of Diazomethane. It has a cytotoxicity effect.This product contains an undetermined amount of water.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Huggins, C., et al.: J. Exp. Med., 131, 321 (1970), Gullino, P.M., et al.: J. Natl. Cancer Inst., 54, 401 (1975),<br></p>

<p>Applications H-D-Ala-D-Leu-OH (cas# 67392-69-2) is a useful research chemical.<br></p>

<p>Applications 2-Methylpentane is used as a raw material/intermediate in organic synthesis, rubber solvent, and vegetable oil extraction solvent.<br>References Choi, D., et al.: Adv. Funct. Mater. 25, 920 (2015)<br></p>

<p>Applications 7,10-Dichloro-2-methoxybenzo[b][1,5]naphthyridine is used in the preparation of pyronaridine.<br>References Li, J., et al.: PCT Int. Appl., 2013:1701510 (2013)<br></p>

<p>Stability Volatile<br>Applications 2-Chloro-2-Methylpentane (cas# 4325-48-8) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications A novel labelled metabolite of Butadiene monoepoxide (BMO), a mutagen and carcinogen compound.<br>References Cheng, X., et al.: Drug Metab. Dispos., 21, 121 (1993), Nieusma, J., et al.: Chem. Res. Toxicol., 10, 450 (1997),<br></p>

<p>Applications Used in the methods of detecting nitrotyrosine and aminotyrosine residues of peptides and proteins. Also used in the studies on the separation and photometric determination of antiepileptics.<br>References Quednow, B., et al.: Pharmazie, 34, 724 (1979),<br></p>

<p>Applications A proteinogenic amino acids involved in the biosynthesis of purines and pyrimidines. Inhibitor of serine palmitoyltransferase. A neuromodulator.<br>References Junjaud, G. et al.: J. Neurochem., 98, 1159 (2006); Hanada, K. et al.: FEBS Lett., 474, 63 (2000); Pollegionni, L. et al.: Cell. Mol. Life Sci., 67, 2387 (2010);<br></p>

<p>Applications 5-Carboxy-2-methylphenylboronic Acid acts as a reagent in the synthesis of pyrazolopyridinone-based p38 MAP kinase inhibitor<br>References Milburn, R. R., et al.: Org. Process Res. Dev., 15, 31 (2011); Achmatowicz, M., et al.: J. Org. Chem., 74, 795 (2009)<br></p>

<p>Applications L-Ornithine-2,3,3,4,4,5,5-d7 hydrochloride is the labelled analogue of L-Ornithine Hydrochloride (O695550), a non-essential amino acid for human development but is required intermediate in arginine biosynthesis. L-Ornithine is found in virtually all vertebrate tissues as well as incorporated into proteins, such as tyrocidine. Isolation from chicken excreta.<br>References Fattori, D., et al.: J. Med. Chem., 50, 550 (2007), Gomez-Alonso, S., et al.: J. Agric. Food Chem., 55, 608 (2007), Subramaniam, R., et al.: Bioorg. Med. Chem. Lett., 18, 3333 (2008),<br></p>

<p>Applications Ademethionine-d3 1,4-Butanedisulfonate, is a labeled analogue of Ademethionine 1,4-Butanedisulfonate (A280355), used in the synthesis of sulfonio-adenosyl-L-methionine (SAMe) salts.<br></p>

<p>Applications 5-((2-Hydroxyethyl)amino)-2-methylphenol (cas# 55302-96-0) is a useful research chemical.<br></p>

<p>Applications It is a versatile industrial solvent. NMP is currently approved for use only in veterinary pharmaceuticals. The determination of the disposition and metabolism of NMP in the rat will contribute toward understanding the toxicology of this exogenous chemical which man may likely be exposed to in increasing amounts.<br>References Southwell, D., et al.: J. Pharm. Pharmacol., 33, 3 (1981), Barry, W., et al.: J. Invest. Dermatol., 82, 49 (1984),<br></p>

<p>Applications 4-Methylfluorene is a polycyclic aromatic hydrocarbon that has been found to be emitted by wastewater treatment facilities.<br>References Zhang, W., et. al.: Sci. Total Environ., 432m 396 (2012)<br></p>

<p>Applications MNC is on the metabolic pathway for 2,4-Dinitotoluene degradation.<br>References Spangoord, R.J., et al.: App. and Environ. Microbiology, 57, 11, 3200 (1991)<br></p>

<p>Applications 2-amino-5-methylhexanoic acid (cas# 3558-32-5) is a useful research chemical.<br></p>

<p>M02961 - H-Phe-OH</p>

<p>Impurity Cefoperazone EP Impurity C<br>Applications N-Methyl-5-tetrazolethiol (Cefoperazone EP Impurity C) is an impurity of Cefoperazone.<br>References Kitson, T., et al.: Biochem. J., 175, 83 (1978), Elenbaas, R., et al.: Clin. Pharmacol. Ther., 32, 347(1982),<br></p>

<p>Applications N-Acetyl-S-phenyl-d5-DL-cysteine is the deuterium labelled form of N-Acetyl-S-phenyl-DL-cysteine, which is used as a reactant in the preparation of potent HIV-1 protease inhibitors that use D-amino acids as P2/P3 ligands.<br>References Jungheim, L., et al.: J. Med. Chem., 39, 96 (1996);<br></p>

<p>Applications 4-Methyl-valerophenone is an intermediate used in the synthesis of a-Pyrrolidinoisohexanophenone (Hydrochloride) (P841230), which is a phenone derivative used for research purposes.<br>References Guo, Z.K., et al.: Marine Drugs, 16, 45/1 (2018)<br></p>

<p>Applications Intermediate for the preparation of Naratriptan and other indole sulfonamide derivatives.<br></p>

<p>Applications 2-Methylalanine is an Alanine (A481400) derivative. Alanine is an amino acid that occurs naturally in nature. It is a functional component in the alanine cycle which regulates the level of alanine aminotransferases which can be used as a diagnostic tool to predict type II diabetes.<br>References Naveed S. et al.: Diab., 53, 11 (2004); Barlind, J. et al.: Bioorg. Med. Chem. Lett., 23, 2721 (2013);<br></p>

<p>Applications 3-Methyl Salicylic Acid is a toxic compound, it’s toxicity is similar to salicylic acid. Reagent used in manufacturing and preparation of dyes.<br>References Egorova, T. V., et al.: Tekstil'naya Promyshlennost , 3, 48 (1987); Keshavarz, M. H., et al.: J. Hazard. Mater., 237, 79 (2012)<br></p>

<p>Applications N-Acetyl-S-(3-hydroxypropyl)-L-cysteine Dicyclohexylamine Salt (unlabelled) (CAS# 14369-42-7) is a useful research compound.<br></p>

<p>Applications 3-Fluoro-4-methoxycarbonylphenylboronic acid, pinacol ester is a useful intermediate for organic synthesis and other chemical transformations.<br>References Zhao, F., et al.: Eur. J. Med. Chem., 134, 147 (2017); Zhao, F., et al.: Bioorg. Med. Chem., 24, 4281 (2016)<br></p>

<p>Stability Light Sensitive<br>Applications 6-Methoxy-2-naphthol is a reactant in the development of sirtuin inhibitors from pyrazolone and isoxazol-5-one cambinol analogs.<br>References Mahajan, S.S., et. al.: J. Med. Chem., 57, 3283 (2014)<br></p>

<p>Applications Boc-4-azido-L-phenylalanine is used in the development of visible fluorogenic dyes for cellular imaging.<br>References Qi, Jianjun., et al.; Bioconjugate Chem., 22, 1758 (2011);<br></p>

<p>Stability Unstable in methanol solution<br>Applications 4-Chloro-2-methylphenol Sulfate Sodium Salt is a halogenated derivative of o-toluenesulfonate, present in landfill leachates. o-Toluenesulfonate is an analog of the strong organic acid p-Toluenesulfonate.<br>References Riediker, S. et al.: Environ. Sci. Tech., 34, 2156 (2000);<br></p>

<p>Applications Labelled 1-Methyl-2-pyrrolidinone (M326120). It is a versatile industrial solvent. NMP is currently approved for use only in veterinary pharmaceuticals. The determination of the disposition and metabolism of NMP in the rat will contribute toward understanding the toxicology of this exogenous chemical which man may likely be exposed to in increasing amounts.<br>References Southwell, D., et al.: J. Pharm. Pharmacol., 33, 3 (1981), Barry, W., et al.: J. Invest. Dermatol., 82, 49 (1984),<br></p>

<p>Applications 7-Methoxy-3,4-dihydro-1-naphthalenyl-acetonitrile (cas# 861960-34-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-(4-Methoxyphenyl)piperazine (cas# 38212-30-5) is a useful research chemical.<br></p>

<p>Applications Felypressin(Octapressin) is a vasopressin 1 agonist and a peptide containing eight amino acids including cystine. Felypressin is used as a vasoconstrictor.<br>References Boissonnas, G., et al.: Helv. Chim. Acta, 43, 190 (1960), Farkas, D., et al.: Curr. Drug Metab., 6, 111 (2005), Elferink, M., et al.: Toxicol. Appl. Pharmacol., 229, 300 (2008),<br></p>

<p>Applications Protected L-Tyrosine (T899975), an amino acid, used by cells to synthesize proteins. L-Tyrosine is biologically converted from L-phenylalanine and is in turn is converted to L-DOPA and further converted into the neurotransmitters: dopamine, norepinephrine, and epinephrine.<br>References Rasmussen D.D. et al.: J. Clin. Endocrinol. Metab., 57, 760 (1983); Bagchi, S.P. et al.: Biochem. Pharmacol., 26, 900 (1977)<br></p>

<p>Applications 2-Amino-3-methylpyridine is used in the synthesis of ketones from aldehydes.<br>References Jun, C. et al.: J. Org. Chem., 62, 1200 (1997); Jun, C. et al.: Angew. Chem. Int. Ed., 37, 145 (1998);<br></p>

<p>Stability Light Sensitive<br>Applications 3-Methyl-diazirine-3-propanoic Acid is a reagent used in crosslinking sugars and photoactivatable crosslinking.<br>References Tanaka, Y. et al.: J. Am. Chem. Soc., 130, 3278 (2008);<br></p>

<p>Applications 4-(4-Chloro-2-methylphenoxy-d3)butyric Acid (CAS# 1219803-42-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Used for the synthesis of Bortezomib from L-phenylalanine via dipeptidyl boronic acid ester intermediates.<br>References Zhu, Y., et al.: J. Med. Chem., 52, 4192 (2009),<br></p>

<p>Applications Protected (S) enantiomer of the amino acid Phenylalanine.<br>References Zhu, P., et al.: Bioorg. Med. Chem. Lett., 19, 6966 (2009), Cramer, B., et al.: Bioorg. Med. Chem., 18, 343 (2010),<br></p>

<p>Applications Labelled 4-Methyl-2-oxovaleric Acid, an α-ketomonocarboxylic acid that triggers insulin release by acting upon receptor sites which differ from those occupied by amino acids. 4-Methyl-2-oxovaleric Acid is an intermediate in the metabolism of Leucine.<br>References Panten, U. et al.: Naun.-Schmied. Arch. Pharmacol., 291, 405 (1975); Vague, P. et al.: Diab. Metab., 1, 185 (1975); Francois, G. et al.: Lancet, 1, 858 (1984);<br></p>

<p>Applications Indole-3-acetyl-L-phenylalanine is an indole-3-acetyl-amino acid conjugate involved in regulatory mechanisms for the control of auxin activity during physiological and pathophysiological responses.<br>References Ostrowski, M., et al.: J Plant Physiol, 191, 63-72 (2016)<br></p>

<p>Applications 1,2-Bismethylphenidate is an impurity of methylphenidate (M325880), an CNS stimulant.<br>References Greenblatt, E.N., et al.: J. Pharmacol. Exp. Ther., 131, 115 (1961), Padmanabhan, G.R., Anal. Profiles Drug Subs., 10, 473 (1981), Srinivas, N.R., et al.: Pharm. Res., 10, 14 (1993),<br></p>

<p>Stability Hygroscopic<br>Applications Dityrosine (DY), a tyrosine dimer formed by 3,3’-biaryl bond formation can be used as a biomarker to detect oxidative protein damage and selective proteolysis. Fluorescence intensity decays of Dityrosine are generally characterized by two decay components, one with a lifetime in the range of 150 to 800 ps and another between 2.5 and 4.5 ns.<br>References Libertini, L., et al.: Biophys. J., 47, 765 (1985), Huggins, T., et al.: J. Biol. Chem., 268, 12341 (1993), Malencik, D., et al.: Biochemistry, 35, 4375 (1996),<br></p>

<p>Applications N-Methyltaurine can be used as a counter ion in the formation of soaps.<br>References Miyahara, Reiji, et al.: J. of Oleo Sci., 50(10), 823-830 (2001)<br></p>

<p>Impurity Carvedilol EP Impurity E; Carvedilol Impurity E; Carvedilol USP E<br>Applications 2-(2-Methoxyphenoxy)ethylamine Hydrochloride (Carvedilol EP Impurity E; Carvedilol Impurity E; Carvedilol USP E) is an impurity of Carvedilol synthesis.<br>References Smith, L., et al.: J. Med. Chem., 20, 1653 (1977),<br></p>

<p>Applications 3,5-Diiodo-DL-tyrosine is used for diagnosis of hypothyroidism caused by DEHAL1 gene defects.<br>References Encinas, S., et al.: Chem. Res. Toxicol., 11, 946 (1998), Daneshvar, A., et al.: Chemosphere, 80, 301 (2010), Eriksson, J., et al.: Photochem. Photobiol., 86, 528 (2010),<br></p>

<p>Applications 2-hydroxy-3-methylpentanoic acid (cas# 488-15-3) is a useful research chemical.<br></p>

<p>Applications Used in the synthesis of DMPO-type spin traps.<br>References Konaka, R., et al.: Free Radical Res., 23, 15 (1995),<br></p>

<p>Applications Butyl 4-methylbenzenesulfonate (cas# 778-28-9) is a useful research chemical.<br></p>

<p>Applications A reagent used to synthesize 5-HT2A and 5-HT3 receptor ligands for use in treating CNS-related disorders.<br>References Bermudez, J., et al.: J. Med. Chem., 33, 1924 (1990),<br></p>

<p>Stability Volatile<br>Applications 3-ETHYL-3-METHYLHEPTANE (cas# 17302-01-1) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications DL-Homocysteine-d4 is used in the detection of the biosynthetic pathway for the formation of volatile aroma compound 2-methyltetrahydrothiophen-3-one by the bacterium Chitinophaga.<br>References Nawrath, T., et al.: ChemBioChem., 11, 1914-1919 (2010)<br></p>

<p>Applications A red azoic dye.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hoover, K., et al.: Chem. Res. Toxicol., 18, 1497 (2005), Altenburger, R., et al.: Environ. Toxicol. Chem., 24, 324 (2005), Gonzalez, M., et al.: Bioorg. Med. Chem., 13, 1775 (2005),<br></p>

<p>Applications A derivative of imidazole used in the synthesis of heteroxanthine.<br>References Sarasin, J., et al.: Helv. Chim. Acta, 7, 713 (1924),<br></p>

<p>Applications N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-alloisoleucine, is a building block used in the synthesis of Ecumicin, which is a the potent anti-mycobacterial cyclic depsipeptide natural product.<br>References Hawkins, P. et al.: Organic Letters, Vol. 20, P: 1019-1022 (2018)<br></p>

<p>Applications 1-Chloro-3-methoxypropane (cas# 36215-07-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,2-Dimethoxy-N-methylethanamine is an impurity formed in the synthetic process of Methimazole (M260300), a thiourea antithyroid agent that prevents iodine organification,<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sitar, D.S., et al.: J. Pharmacol. Exp. Ther., 184, 432 (1973), Aboul-Enein, H.Y., et al.: Anal. Profiles Drug Subs., 8, 351 (1979), Cooper, D.S., et al.: N. Engl. J. Med., 311, 1353 (1984), Atterwill, C.K., et al.: Food Chem. Toxicol., 29, 355 (1991),<br></p>