Amino Acids (AA)

<p>Applications 2-Methoxyphenylsulfate is used in the analysis of alkylsulfatases and their kinetics.<br>References Bateman, T. et al.: Biochem. J., 236, 401 (1986);<br></p>

<p>Applications N-methyl-6-(2,2,2-trifluoroethoxy)-1,3,5-triazine-2,4-diamine (cas# 101988-70-9) is a useful research chemical.<br></p>

<p>Applications A labelled metabolite of Crotonaldehyde.<br>References Gray, J.M., et al.: Xenobiotica, 1, 55 (1971), Chung, F., et al.: Mutat. Res., 424, 71 (1999), Smith, C., et al.: Food Chem. Toxicol., 38, 637 (2000), Pan, J., et al.: Chem. Res. Toxicol., 15, 367 (2002),<br></p>

<p>Applications (±)-3-Amino-iso-butyric-2,3,3-d3 Acid is the labeled version of DL-3-Aminoisobutyric Acid (A603043(P)), which is a useful compound for suppressing atherosclerosis in apolipoprotein E-knockout mouse.<br>References Shimba, Y., et al.: Bio. Pharma. Bull., 43, 1016 (2020)<br></p>

<p>Applications 4-methyl-2-(piperidin-4-yl)pyridine (cas# 1260886-47-2) is a useful research chemical.<br></p>

<p>Applications 4-Chloro-3-methylaniline (cas# 7149-75-9) is a compound useful in organic synthesis.<br></p>

<p>Applications [2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-1-yl]acetic acid (cas# 1171565-50-6) is a useful research chemical.<br></p>

<p>Stability Unstable in Aqueous Solution<br>Applications 2-METHYL-1,4-BUTANEDIOL (cas# 2938-98-9) is a useful research chemical.<br></p>

<p>Applications (4R, 2S)-4-Hydroxy-1-(9-phenyl-9H-fluoren-9-yl)-proline Methyl Ester (cas# 179990-59-1) is a compound useful in organic synthesis.<br></p>

<p>Stability Hygroscopic<br>Applications Labelled N-Acetyl-S-(carbamoylethyl)-L-cysteine (A171870). N-Acetyl-S-(carbamoylethyl)-L-cysteine is the urinary metabolite of Acrylamide (AA). Acrylamide is formed during the heating of food and is classified as a genotoxic carcinogen.<br>References Besaratinia, A., et al.: Mutat. Res., 80, 31 (2005), Bjellaas, T., et al.: Xenobiotica, 35, 1003 (2005), Bjellaas, T., et al.: Food Chem. Toxicol., 45, 1020 (2007), Bjellaas, T., et al.: Toxicol. Sci., 98, 110 (2007),<br></p>

<p>Applications 2-Methoxypropyl Acetate causes moderate irritation, significant reduction in body weight development and thymic atrophy in rats as well as pronounced prenatal toxicity in rats.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ma-Hock, L., et al.: Hum. Exp. Toxicol., 24, 95-99 (2005)<br></p>

<p>Applications 3-Ethyl-2-methyl-2-(3-methylbutyl)-oxazolidine is a oxazolidine-based moisture scavenger for use in urethane coatings, sealants and elastomers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Isotope labelled Intermediate for transsulfuration whereby a mammal transfers the sulfur of methionine via homocysteine to cysteine.<br>References Thompson, J.W., et al.: J. Biol. Chem., 266, 17011 (1991), Yoshida, Y., et al.: Microbiol., 148, 3961 (2002), Jiracek, J., et al.: J. Med. Chem., 49, 3982 (2006),<br></p>

<p>Applications L-Glutamic acid dibenzyl ester 4-toluenesulfonate<br></p>

<p>Applications 4,4'-Methylenebis[2-chlorophenol] is used in the manufacture of fire-resistant polyester material and is used in the synthesis of photo-sensitive print plates.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yu, S. et al.: Faming Zhuanli Shenqing (2009), CN 101597219 A 20091209.<br></p>

<p>Stability Hygroscopic<br>Applications (S)-(+)-2-Methylbutyric Acid is a chiral starting reagent used in various synthetic preparations.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Neves, F., et al.: Beilstein. J. Org. Chem., 7, 1504 (2011); King, A.M., et al.: J. Medn. Chem., 54, 6432 (2011); Ferrarni, A., et al.: Chirality., 26, 9 (2011);<br></p>

<p>Applications L-Hydroxyprolylglycine_x000D__x000D (cas# 7672-35-7) is a useful research chemical.<br></p>

<p>Applications δ-Valerolactam-d4 is a labeled analog of δ-Valerolactam (V091440), which is a useful synthetic intermediate. It is an intermediate used to synthesize Cenicriviroc (C256550), an experimental drug candidate for the treatment of HIV infection. It is also a starting material for a new route to hexahydrojulolidines, using intramolecular 1,4-cycloaddition.<br>References Potts, K., et al. J. Org. Chem., 58, 5040 (1993); Klibanov, O., et al.: Curr. Opinion Invest. Drugs, 11, 940 (2010);<br></p>

<p>Applications Pipecolic acid is involved in synaptic transmission in the central nervous system. The l-form occurs in plants.<br>References Nomura Y., et al.: Neurochem. Res., 6, 391 (1981),<br></p>

<p>Applications N-ACETYLISOLEUCINE (cas# 3077-46-1) is a useful research chemical.<br></p>

<p>Applications 4-Amino-2-methyl-5-pyrimidinemethanesulfonic acid is used in the biosynthesis of Thiamine (T344185) in yeast.<br>References White, R., et al.: Journal of the American Chemical Society, 104, 4934 (1982).<br></p>

<p>Applications Intermediate in the preparation of 2,3-Desisopropylidene Topiramate, a metabolite of Topiramate<br></p>

<p>Applications 3-Methoxy-1,2-propanediol is used to prepare phosphorothioate analogs of sn-2 radyl lysophosphatidic acid as metabolically stabilized LPA receptor agonists. It is also used to synthesize diacylglycerol analogs as potential second-messenger antagonists.<br>References Jiang, G., et al.: Bioorg. Med. Chem. Lett., 23, 1865 (2013); Briggs, J., et al.: Bioorg. Med. Chem. Lett., 2, 127 (1992)<br></p>

<p>Impurity Temozolomide USP Related Compound B<br>Applications N'-Methyl-N,N-diphenylurea is used in the stabilization of thermal propellants. Temozolomide USP Related Compound B.<br>References Bohn, M. et al.: Prop. Exp. Pyro.,et al.: 19, 266 (1994); Muthurajan, H. et al.: J. Hazard. Mat., 133, 30 (2006);<br></p>

<p>Stability Air Sensitive<br>Applications A metabolite of Methyl Isocyanate.<br>References Slatter, J. G., et al.: Chem. Res. Toxicol., 4, 157 (1991),<br></p>

<p>Applications Ethylenediaminetetraacetic Acid-d16 (CAS# 203805-96-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromo-3-methylbutane, is used as an extraction solvent to determine various polycyclic aromatic hydrocarbons in water samples though dispersive liquid-liquid microextraction along with GC-MS (gas chromatography- mass spectrometry).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rezaee, M., et al.: J. Chromat. A., 1116, 1 (2006)<br></p>

<p>Applications L-Aspartic Acid is a non-essential amino acid found in food sources. L-Aspartic Acid is one of the 20 proteinogenic amino acids; the building blocks of proteins. Its conjugate base L-aspartate is an excitatory neurotransmitter in the central nervous system.<br>References Ager, D.J. et al.: J. Mol. Catal. Enzym., 11, 199 (2001); Velisek, J. et al.: Cze. J. Food. Sci., 24, 1 (2006); Nagahama, M. et al.: Cell Tiss. Res., 318, 483 (2004);<br></p>

<p>Stability Hygroscopic<br>Applications CEL and CML are two stable, nonenzymatic chemical modifications of protein lysine residues resulting from glycation and oxidation reactions.<br>References Fu, M.X., et al.: J. Biol. Chem., 271, 9982 (1996), Ahmed M.U., et al.: Biochem.J., 324, 565 (1997), Schleicher, E.D., et al.: J. Clin. Invest., 99, 457 (1997), Shibayama, R., et al.: Diabetes, 48, 1842 (1999),<br></p>

<p>Applications 2-Methoxyethyl 3-oxobutanoate (cas# 22502-03-0) is a useful research chemical.<br></p>

<p>Stability Hygroscopic, Light Sensitive<br></p>

<p>Applications Methyl 4-Methoxysalicylate, is an organic building block, used for the synthesis of (+)-coriandrone A and B, two bioactive natural products. It can also be used for the preparation of Dimethoxybenzofuran derivatives as potent and selective inhibitors of CYP2A6.<br>References Wang, W., et al.: Org. Biomol. Chem., 11, 6686 (2013); Yamaguchi, Y., et al.: Heterocycles, 87, 1727 (2013);<br></p>

<p>Impurity Verapamil EP Impurity K<br>Applications (Verapamil EP Impurity K)<br></p>

<p>Applications 3-Bromo-5-methoxypyridine<br></p>

<p>Applications L-Threonic acid calcium salt is the salt of L-Threonic acid, a naturally occurring compound that can be found in the leaves of Pelargonium crispum. L-Threonic acid is also the degradation product of Dehydroascorbate (DHA), a metabolite of Vitamin C (A786990).<br>References Helsper, J. &amp; Loewus, F.: Plant Phys., 69, 1365 (1982); Koch, C. &amp; Biaglow, J.: J. Cell. Phys., 94, 299 (1978); Nielsen J., et al.: J. Agr. Food Chem., 49, 2998 (2001)<br></p>

<p>Applications N-Acetyl-L-phenylalanine is an protected analogue of L-Phenylalanine (P319415), an essential amino acid produced for medical, feed, and nutritional applications such as in the preparation of Aspartame.<br>References Sriram, S., et al.: J. Med. Chem., 56, 2540 (2013); Parker, B.M., et al.: J. Biotech., 155, 396 (2011);<br></p>

<p>Applications 1-(2-METHOXYPHENETHYL)PIPERAZINE (cas# 6722-54-9) is a useful research chemical.<br></p>

<p>Applications 2-Furoylglycine is an intermediate used to prepare non-nucleoside inhibitors of HCV NS5b RNA polymerase. It is also used in the synthesis of benzimidazolylazabicyclooctylethylpiperidines as Ccr5 antagonists for the treatment of HIV infection.<br>References Antonysamy, S., et al.: Bioorg. Med. Chem. Lett., 18, 2990 (2008); Kazmierski, W., et al.: PCT Int. Appl. (2004), WO 2004054974 A2 20040701<br></p>

<p>Applications 2,2-Dimethoxy-N-methylethanamine is an impurity formed in the synthetic process of Methimazole (M260300), a thiourea antithyroid agent that prevents iodine organification,<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sitar, D.S., et al.: J. Pharmacol. Exp. Ther., 184, 432 (1973), Aboul-Enein, H.Y., et al.: Anal. Profiles Drug Subs., 8, 351 (1979), Cooper, D.S., et al.: N. Engl. J. Med., 311, 1353 (1984), Atterwill, C.K., et al.: Food Chem. Toxicol., 29, 355 (1991),<br></p>

<p>Applications 2-Methylresorcinol (cas# 608-25-3) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Impurity Rifaximin EP Impurity A<br>Applications 2-Amino-4-methylpyridine (Rifaximin EP Impurity A) is an impurity of Rifaximin.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Hydroxyprolines are valuable chiral building blocks for organic synthesis of pharmaceuticals. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.<br>References Lawrence, C., et al.: Biochem. J., 313, 185 (1996), Mori, H., et al.: J. Bacteriol., 179, 5677 (1997), Clifton, I., et al.: Eur. J. Biochem., 268, 6625 (2001),<br></p>

<p>Applications 2,3-Diethyl-5-methylpyrazine-N4-oxide (cas# 1076200-01-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Guaiacol-beta-D-glucopyranoside, is a Guaiacol Conjugate, that has shown to present in fermentation of grapes that had been exposed to bushfire smoke and can potentially yield unpalatable, smoke-affected wine.<br>References Hayasaka, Y.m et al.: J. Arg. Food Chem., Vol. 58, Issue 4, P: 2076; 2081 (2010);<br></p>

<p>Applications 2-Ethyl-4-methyl-1-pentanol is a volatile chemical that can be used to diagnose ratoon stunting disease in Sugar cane.<br>References Berna, A. Z., et al.: Pro. of the Conf. of the Austr. Soc. of Sugar Cane Tech., 37th, 150-157 (2015)<br></p>

<p>Applications L-Methionine-3,3,4,4-d4 (CAS# 67866-75-5) is a useful isotopically labeled research compound.<br></p>

<p>Impurity Paliperidone USP Related Compound A<br>Applications 3-Ethyl-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (Paliperidone USP Related Compound A) is used in the synthesis of Paliperidone (P141000). Intermediate.<br>References Rein, A., et al.: Curr. Opin. Drug Discovery Dev., 3, 734 (2000),<br></p>

<p>Applications N-Acetyl-DL-aspartic acid (cas# 2545-40-6) is a useful research chemical.<br></p>

<p>Applications 4-Methyl-d3-catechol (CAS# 83719-41-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications L-Lysine L-Malate is used in the preparation of amino acid ionic liquids for use in food and medical field.<br></p>

<p>Applications D-Serine Methyl Ester Hydrochloride (cas# 5874-57-7) is a compound useful in organic synthesis.<br></p>

<p>Applications N-Acetyl-L-glutamic Acid is the N-Acetyl analogue of the non-essential amino acid, L-glutamic acid (G596960). N-Acetyl-L-glutamic Acid activates carbamoyl phosphate synthetase in the urea cycle.<br>References Saheki, T. et al.: J. Biochem., 77, 659 (1975); Rivas, J. et al.: Acta Biol. Med. Ger., 36, 1673 (1977); Zollner, H.: Biochim. Biophys. Acta, 676, 170 (1981);<br></p>

<p>Applications (S)-2-Amino-4-[(3-aminopropyl)amino]-butanoic Acid is used in the reaction of carboxynorspermidine decarboxylase of Vibrio alginolyticus.<br>References Nakao, H., et al.: J. Gen. Microbiol. 136, 1699-704 (1990)<br></p>

<p>Applications An essential amino acid for human development. Precursor for nitric oxide. Ammonia detoxicant (hepatic failure); diagnostic aid (pituitary function).<br>References Miura, T., et al.: Anal. Biochem., 139, 432 (1984), Jones, et al.: Adv. Enzyme Regul., 9, 19 (1970), Borders, C.L., et al.: Protein. Sci., 3, 541 (1994),<br></p>

<p>Applications 5-Hydroxy-N-methyl-2-pyrrolidinone is a metabolite of N-methylpyrrolidone (NMP).<br>References Payan, J., et al.: Drug Metab. Dispos., 30, 1418 (2002), Carnerup, M., et al.: Food Chem. Toxicol., 43, 1441 (2005), Angerer, J., et al.: Toxicol. Sci., 93, 3 (2006),<br></p>

<p>Applications A proteinogenic amino acids involved in the biosynthesis of purines and pyrimidines. Inhibitor of serine palmitoyltransferase. A neuromodulator.<br>References Junjaud, G. et al.: J. Neurochem., 98, 1159 (2006); Hanada, K. et al.: FEBS Lett., 474, 63 (2000); Pollegionni, L. et al.: Cell. Mol. Life Sci., 67, 2387 (2010);<br></p>

<p>Applications L-Ornithine-2,3,3,4,4,5,5-d7 hydrochloride is the labelled analogue of L-Ornithine Hydrochloride (O695550), a non-essential amino acid for human development but is required intermediate in arginine biosynthesis. L-Ornithine is found in virtually all vertebrate tissues as well as incorporated into proteins, such as tyrocidine. Isolation from chicken excreta.<br>References Fattori, D., et al.: J. Med. Chem., 50, 550 (2007), Gomez-Alonso, S., et al.: J. Agric. Food Chem., 55, 608 (2007), Subramaniam, R., et al.: Bioorg. Med. Chem. Lett., 18, 3333 (2008),<br></p>

<p>Applications (2-methylphenoxy)acetic acid (cas# 1878-49-5) is a useful research chemical.<br></p>

<p>Applications Labelled analogue of an essential amino acid found in naturally produced peptides. Unlike its stereoisomer, L-tryptophan, it is not used in structural or enzyme proteins.<br>References Karunakaran, S.et al.: Bochem. J., 414, 343 (2008); Pallaghy, P.K. et al.: Biochem., 38, 11553 (1999);<br></p>

<p>Applications 3-Methylbutane-1,2,3-tricarboxylic Acid is an atmospheric oxidation product of α-pinene that is a tracer compound for atmospheric terpene secondary organic aerosol (SOA) particles.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dette, H.P., et. al.: J. Phys. Chem. A., 118, 7024 (2014)<br></p>

<p>Applications Methyl(4-methylnaphthalen-1-ylmethyl)amine is a reagent in the preparation of heterocyclic compounds as enoyl-acyl carrier protein reductase FabI inhibitors and antibacterial agents.<br>References Stuetz, A., et al.: J. Med. Chem., 29, 112 (1986); Berman, J., et al.: PCT Int. Appl., 2004:515512 (2004)<br></p>

<p>Stability Light Sensitive<br>Applications α-Methacrylic acid is used in chemistry as a stabilizing agent, forming a thin capping layer on the surface of nanoparticles. α-Methacrylic acid is also used as a surfactant, so that control is maintained during nanocrystal growth. α-Methacrylic acid is also used as a chelating agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Peng, W., et al.: J. Cryst. Growth, 279, 454 (2005); Qu, S., et al.: Appl. Phys. Lett., 80, 3605 (2002); Zhao, G., et al.: Phys. C: Supercond., 468, 2317 (2008)<br></p>

<p>Applications Labelled 4-Methoxyestrone (M226135). An endogenous estrogen metabolite, risk-factor for development of breast cancer.<br>References Beral, V., et al.: Lancet, 362, 419 (2003), Nelson, R., et al.: Clin. Chem., 50, 373 (2004), Malekinejad, H., et al.: J. Agric. Food Chem., 54, 9785 (2006),<br></p>

<p>Applications N-Methyl-p-toluenesulfonamide is an intermediate used in the synthesis of vicinal haloamino ketone derivative.<br>References Sun, H., et al.: Chem. Biol. Drug Design, 75, 269 (2010)<br></p>