Amino Acids (AA)

Applications D-Glutamic Acid 1,5-Dimethyl Ester Hydrochloride, is a diester analogue of D-Glutamic Acid (G596965), a non-essential amino acid. It can also be used for the synthesis of more complex pharmaceutical compounds.
References McEntee, W. et al.: Psychopharmacology, 111, 391 (1993); Manev, H. et al.: Mol. Pharmacol., 36, 106 (1989);

Applications N,N-Bis(7-methyloctanyl)trifluoromethane Sulfonamide (cas# 1246815-82-6) is a compound useful in organic synthesis.

Applications N,N-Diisopropyl-3-(2-methoxy-5-methyl-phenyl)-3-phenylpropylamide-d14 (cas# 1795013-34-1) is a compound useful in organic synthesis.

Applications 8-Hydroxy-5-methyloctanoic Acid is a starting material and useful building block of various pharmaceuticals.

Applications 4,4'-[2,2,2-Trifluoro-1-(trifluoromethyl)ethylidene]-O-benzyl Mono-β-D-glucuroniC Acid Methyl Ester 2,3,4-O-Triacetate is an intermediate used in the synthesis of 4,4'-[2,2,2-Trifluoro-1-(trifluoromethyl)ethylidene]bisphenol Mono-β-D-glucuronide (T792735), which is a metabolite of 2,2-Bis-(4-hydroxyphenyl)hexafluoropropane (B447290), which acts as an endocrine-disrupting chemical (EDC), activating estrogen through the estrogen receptor ERα. It is a full agonist for the estrogen receptor.
References Matsushima, A. et al.: Environ. Health, Perspect. 118, 1267 (2010);

Applications 1-Methyldibenzothiophene, is an alkyldibenzothiophene present in crude oil. Research concerning the biodegradation of Dibenzothiophene by different types of bacteria is a currently being carried out, as these bacteria have the ability to breakdown other harmful PAH’s as well. This may be used in removing spilled oil from marine and terrestrial environments.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Boberg, F., et al.: Erdoel & Kohle, Erdgas, Petrochemie, 47, 187 (1994); Tanaka, Y., et al.: Applied Microbiology and Biotech., 59 (2), 325 (2002); Prince, R., Spill Sci. Tech. Bulletin, 8 (2), 145 (2003);

Applications Boc-L-His(Tos)-OH, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

Applications (E)-1-(4-(4-(2-Methylbut-2-en-1-yl)piperazin-1-yl)phenyl)ethanone is an intermediate in the synthesis of (E)-1-(4-(4-(2-Methylbut-2-en-1-yl)piperazin-1-yl)phenyl)ethanone Hydrochloride (M725995), which is a piperazinyl phenylethanone compound that acts as an inhibitor of traffic between the trans-Golgi network (TGN) and endosomes that depends on the clathrin adaptor complex AP-1. Additionally, Membrane Traffic Inhibitor, A5 has been shown to have little effect against other trafficking pathways involving endosomes and TGN.
References Duncan, M. C., et al.: Proc. Natl. Acad. Sci. U S A, 104, 6235 (2007)

Applications 1-Methoxy-4-(2-methyl-2-nitropropyl)benzene-d3 is an isotope labelled substituent in the synthesis of Olodaterol (O262000), a novel inhaled β2-adrenoceptor agonist with a 24h bronchodilatory efficacy.
References Bouyssou, T., et al.: Bioorg. Med. Chem. Lett., 20, 1410 (2010);

Applications Ethyl 3-Methyl-2-butenoate-d6 (cas# 53439-15-9) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 2-Methyl-3,4,6-trifluorobenzoic Acid is an intermediate in the synthesis of dl-Grepafloxacin (G783000), which is an antibacterial compound used to treat various respirator infections.
References O'Shea, R. et al.: J. Med. Chem., 51, 2871 (2008); Zhanel, G. et al.: Drugs, 62, 13 (2002);

Applications (R)-3,5-Dihydroxy-3-methylpentanenitrile is an intermediate in enantioselective synthesis of mevalonolactone.
References Eliel, E. L., et al.: Tetrahedron. Lett., 22, 2859 (1981);

Applications Can be used in the preparation of substances for treatment of dermatological conditions and skin protection.

Applications An intermediate in the preparation of labelled Ethosuximide.

Applications Methyl 2-(4-(4-Chlorobut-1-yn-1-yl)phenyl)-2-methylpropanoate is an intermediate in the synthesis of 4-(4-Chloro-1-oxobutyl)-α,α-dimethylbenzeneacetic Acid Methyl Ester (C374930), a fexofenadine (F322490) intermediate.
References Chang, R., et al.: Eur. J. Pharmacol., 48, 463 (1978), McTavish, D., et al.: Drugs, 39, 552 (1990), Honig, P., et al.: Clin. Pharmacol. Ther., 52, 231 (1992), Yun, C., et al.: Drug Metab. Dispos., 21, 403 (1993),

Applications 4-Methylbenzyl alcohol (cas# 589-18-4) is a useful research chemical.

Stability Smelly, Air Sensitive
Applications 4-Methylbenzenethiol is used as a reactant in the preparation of sulfides by palladium-catalyzed coupling with aryl halides or sulfonates in presence of Josiphos ligand.
References Fernandez-Rodriguez, M., et al.: J. Am. Chem. Soc., 128, 2180 (2006);

Applications 2-Bromo-4’-methylacetophenone-d3 (cas# 959605-55-1) is a compound useful in organic synthesis.

Applications Ethyl-d5 2-Methylbutyrate is the labeled analogue of Ethyl 2-Methylbutyrate (E923200), an ester that has a sweet, apple-like aroma. Ethyl 2-methylbutyrate is naturally found in apples, cherries and orange juice.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cho, I., et al.: J. Agr. Food Chem., 54, 6332 (2006); Mattheis, J., et al.: J. Agr. Food Chem., 45, 212 (1997); Moshonas, M. & Shaw, P.: J. Agr. Food Chem., 35, 161 (1987); Willaert, G., et al.: J. Agr. Food Chem., 31, 809 (1983)

Applications N-Nitro-S-methylisothiourea-13C is an intermediate used in the synthesis of Clothianidin-d3, 13C1 (C588502), which is the isotope labelled analog of Clothianidin. Clothianidin is a neonicotinoid insecticide for use in food crops.
References Kamel, A., et al.: J. Agric. Food Chem., 58, 5926 (2010), Lynd, L., et al.: Energy Environ. Sci., 3, 1150 (2010), Cresswell, J., et al.: Ecotoxicology, 20, 149 (2011),

Applications An intermediate in the preparation of labelled Cletoquine, Chloroquine and respective derivatives
References Cavallaro, R., et al.: J. Med. Chem., 42, 2527 (1999), Fellmann, P., et al.: Biochem., 39, 4994 (2000),

Applications N-Isopropyl-N-methylamine-d7 Hydrochloride is an intermediate in the synthesis of Saflufenacil-d7 (S081802). Saflufenacil-d7 is the labeled version of Saflufenacil (S081800), which is a herbicide of the pyrimidinedione chemical class used for the preplant burndown and selective preemergence dicot weed control in different field crops. It was found to inhibit protoporphyrinogen IX oxidase (PPO) enzyme.
References Knezevic, S., et al.: Crop Prot., 29, 148 (2010); Grossmann, K., et al.: Weed Sci., 58, 1 (2010)

Applications 2,2,2-Trichloro-1-(1-methyl-4-nitro-1H-pyrrol-2-yl)ethanone (cas# 120122-47-6) is a useful research chemical.

Applications N-tert-Boc-2-(4-hydroxy-2-methoxyphenoxy)ethylamine-d3 (cas# 1189659-07-1) is a compound useful in organic synthesis.

Applications O-Methyloxime Guanosine-13C15N2 is an isotope labelled intermediate in the preparation of nucleotide analogs.
References Robins, M. J., et al.: J. Am. Chem. Soc., 105, 4059 (1983);

3-(Bromomethyl)-5-methyl-1,2,4-oxadiazole is an activating molecule that can be used as a histochemical stain. It forms a blue dye when reacted with the amino acid histidine in tissue. This compound stains cells and tissues blue, which can be used to identify different types of cells. 3-(Bromomethyl)-5-methyl-1,2,4-oxadiazole is also useful for identifying the location of specific proteins by detecting their presence in different types of cells. This compound can also be used in vivo to activate angiotensinogen in wild-type mice and then analyzing the effects on angiotensin levels.

4-Methylphenyl hydrazine hydrochloride is a chemical compound that has been shown to be an effective treatment for lung tumors. It has been shown to inhibit tumorigenesis in animal models by the inhibition of angiogenesis and tumor growth. This drug is administered as a subcutaneous injection and can cause hemorrhaging, inflammation, and necrosis at the injection site. 4-Methylphenyl hydrazine hydrochloride has also been postulated to have anti-tumorigenic properties in animals.
4-Methylphenyl hydrazine hydrochloride inhibits the production of adenomas and adenocarcinomas in rats when given orally or intragastrically, but not when given intravenously.

(R)-(+)-N-Benzyl-1-phenylethylamine is an enantiomer of phenylethylamine. It is a chiral, vinylic amine that can be used to produce catalytic asymmetric Grignard reactions. The synthesis of this compound starts with the addition of benzyl chloride to 1-phenylethylamine. This reaction produces (R)-(+)-N-benzyl-1-phenylethylamine as the major product and its corresponding bisulfate salt as the minor product. This compound has been shown to be an anti HIV drug in a number of studies, which may be due to its ability to inhibit reverse transcriptase and/or prevent viral entry into cells.

2,4-Dimethoxy-5-methylbenzyl alcohol is a high quality chemical that is used as an intermediate for the synthesis of complex compounds. It has been used as a reagent and as a building block for the synthesis of other chemicals. This compound can be used to produce fine chemicals and research chemicals. 2,4-Dimethoxy-5-methylbenzyl alcohol has been shown to be useful in the production of versatile building blocks and reaction components.

Rengasin-3'-O-glucoside is a fine chemical, useful building block, and research chemical. It is a versatile building block that can be used in the synthesis of complex compounds. Rengasin-3'-O-glucoside is also a useful intermediate or scaffold for reactions. This compound has been shown to react with 1,2-ethanediol and form an ester, which can be hydrolyzed to release glycerol and the original rengasin-3'-O-glucoside.

Boc-L-indoline-2-carboxylic acid is a high quality, versatile building block that can be used as a reagent or intermediate in organic synthesis. It is used as a research chemical and has potential applications in the development of new drugs. Boc-L-indoline-2-carboxylic acid is a complex compound that reacts with nucleophiles to form valuable products. It also has the ability to bind to metal ions such as copper, zinc, and nickel. This product can be used in reactions involving amines, alcohols, amides, phenols, carboxylic acids, sulfonic acids, and other compounds.

2'-(4-Ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bi-1H-benzimidazole trihydrochloride (EPMB) is a DNA binding agent that is used in tumor detection and research into apoptosis. It has been shown to inhibit the activity of p-glycoprotein, which is an efflux pump protein, and Bcl-2 protein. EPMB has also been shown to cause apoptosis in human squamous cell carcinoma cells in a concentration dependent manner. This compound has shown potential as a treatment for cancer because it inhibits the ability of cancer cells to proliferate by binding to the NMDA receptor.

1,3-Phenylenediacetic acid is a molecule that contains an aromatic ring and two carboxylate groups. It has been shown to react with collagen and water molecules by forming hydrogen bonds. 1,3-Phenylenediacetic acid also reacts with the hydroxyl group in the cell culture media to form a crosslink between two molecules. This reaction was found to be responsible for the observed increase in stiffness of collagen gels. The vibrational and macroscopic analysis of 1,3-phenylenediacetic acid has also revealed that it adopts a tetranuclear structure at room temperature.

5-Methoxydurmillone is a rotenoid that is found in many plants, including the seeds of the plant Ferruginea. 5-Methoxydurmillone has been shown to have anti-inflammatory properties and can be used to treat inflammatory diseases such as arthritis. It also inhibits the production of superoxide radicals and nitric oxide, which are important mediators of inflammation. 5-Methoxydurmillone has been shown to inhibit protein synthesis in bacteria, but not mammalian cells.

2-Iodo-N-methyl-N-p-tolylbenzamide is a fine chemical that has the CAS No. 1387529-49-8 and is a versatile building block with a wide range of applications, including research chemicals, reaction components and speciality chemicals. 2-Iodo-N-methyl-N-p-tolylbenzamide is soluble in organic solvents such as ethers, chloroform and benzene, while insoluble in water. It has been shown to be a useful intermediate for the synthesis of complex compounds and can be used as a reagent to prepare other compounds. 2Iodo-Nmethyl--Np--tolylbenzamide has been shown to have high quality and is an excellent building block for synthesizing pharmaceuticals.

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