Amino Acids (AA)

Applications (±)-Aspartic Acid, is a non-essential amino acid found in food sources. Its conjugate base D-aspartate has potential use as a a therapeutic agent in the treatment of schizophrenia-related symptoms.
References Errico, F. et al.: J. Neurosci., 28, 10404 (2008); Denu, J.M. et al.: Biochem., 34, 3396 (1995); Chen, P.E. et al.: Mol. Pharmacol., 67, 1470 (2005);

Applications L-4-Hydroxyphenyl-2,6-d2-alanine-2-d1 (CAS# 71939-39-4) is a useful isotopically labeled research compound.

Applications 4-(1,3-Benzodioxol-5-yl)-1,4,6,7-tetrahydro-1-methyl-7-oxo-3-phenyl-8H-pyrazolo[3,4-e][1,4]thiazepine-8-acetic Acid

Applications Nα-Boc-L-histidine is an N-Boc-protected form of L-Histidine (H456010). L-Histidine is an essential amino acid that plays an important role in mitochondrial glutamine transport and has potential of abolishing oxidative stress caused by brain edema.L-Histidine promotes zinc uptake in human erythrocyes and also has potential as an antioxidant therapy for acute mammary inflammation in cattle.
References Chaiyotwittayakun, A., et al.: J. Dairy Sci., 85, 60 (2002); Horn, N., et al.: J. Phys., 489, 73 (1995); Rama Rao, K., et al.: Am. J. Path., 176, 1400 (2010);

Applications α-[[[2-(4-Methoxy-3-methylphenyl)-1-methylethyl](phenylmethyl)amino]methyl]-3-nitro-4-(phenylmethoxy)benzenemethanol is an intermediate in the synthesis of (3R,5S)-Fluvastatin.
References Faming Zhuanli Shenqing (2014), CN 103896795 A 20140702.

Applications N-[1-Deoxy-2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranos-1-yl]-L-valine is an intermediate used in the synthesis of Fructose Valine (F792595), which is an amadori compound having the potential to alter cellular adhesion, inhibit cancer metastasis and induce apoptosis.
References Horiuchi, T., et al.: Agric. Biol. Chem., 55, 333 (1991), Sosnovsky, G., et al.: J. Pharm. Sci., 82, 649 (1993), Glinsky, G., et al.: Cancer Res., 56, 5319 (1996),

Applications 2-Methylbenzenesulfonic Acid Dihydrate is a reagent used in the solubility studies of sulfonic acid hydrates in sulfuric acids and in water acid systems.
References Kozlov, V. A., et al.: Zhurnal Obshchei Khimii, 54, 1469 (1984); Kozlov, V. A., et al.: Izv. Vyssh. Uchebn. Zaved., Khim.Khim. T., 21, 797 (1978)

Applications Fmoc-Asp(OMe)-OH is a useful research intermediate used in the solid phase synthesis of peptides as selective caspase-3 peptide inhibitors.
References Grimm, Erich L., et al.: Bioorg. Med. Chem., 12, 845 (2004); Vickers, C. J., et al.: J. Am. Chem. Soc., 135, 12869 (2013)

Applications N-Cbz-D-methionine is an N-Cbz-protected form of D-Methionine (M260550). D-Methionine is an isomer of L-Methionine (M260440), and is known to be a cytoprotectant against Cisplatin (C499500), an anticancer agent. D-Methionine is also used to prevent noise- and drug-induced hearing loss, as well as hair loss (all of which may also be caused by Cisplatin or aminoglycosides).
References Campbell, K., et al.: Hear. Res., 92, 103 (2007); Cloven, N., et al.: Antican. Res., 20.6B, 4205 (1999); Vuyyuri, S., et al.: Clin. Cancer Res., 14, 2161 (2008)

Applications D-Isoleucine is not biosynthesized in the human body and is therefore categorized as an essential amino acid that must be obtained through diet. It is also an important building block that is used in the formation of hemoglobin in humans.
References Albanese, A.: J. Biol. Chem., 157, 613 (1945); Martin, R. & Kirk, K.: Blood, 109, 2217 (2007)

Applications A protected glutamic acid for use in peptide synthesis.
References Takahashi, M., et al.: J. Exp. Biol., 200, 401 (1997), Michaelis, E., et al.: Prog. Neurobiol., 54, 369 (1998), Koch, H., et al.: Mol. Pharmacol., 55, 1044 (1999), O'Kane, R., et al.: J. Biol. Chem., 274, 31891 (1999),

Applications An amino acid amide and intermediate in the preparation of L-Tryptophanamide Hydrochloride (Cat. #T89550).
References Smith, E.L., and Polglase, W.J.: J. Biol. Chem., 180, 1209 (1949)