Amino Acids (AA)

Applications 2-Hydroxy-methoxy-5-nitropyridine is used in the preparation of Rho-Kinase inhibitors that display antihypertensive activity. Also it is used in the preparation of aminofurans as potent inhibitors of AKT kinase.
References Rouse, M. et al.: Bioorg, Med. Chem. Lett., 19, 1508 (2009); Stavenger, R. et al.: J. Med. Chem., 50, 2 (2007);

Applications 1-[4-[3-(4-Acetyl-2-methoxyphenoxy)propoxy]-3-ethoxyphenyl]ethanone is an impurity of Iloperidone (I267200); an atypical antipsychotic drug used in the treatment of schizophrenia.
References Ichikawa, J., et al.: Brain Res., 956, 349 (2002); Potkin, S. G., et al.: J. Clin. Psychopharm., 28, S4 (2008)

Applications Methyl 2-methyl-3-nitrobenzoate is used as a reagent to synthesize Lenalidomide (L328000). Lenalidomide is a compound that exhibits antimyeloma, anticancer and immunomodulatory activity and is used to treat patients with B-cell malignancies.
References Balaev, A., et al.: Pharm. Chem. J., 46, 676 (2013); Chanan-Khan, A. & Cheson, B.: J. Clin. Oncol., 26, 1544 (2008); Dredge, K., et al.: Microvasc. Res., 69, 56, 69 (2005); Palumbo, A., et al.: J. Clin. Oncol., 25, 4459 (2007)

Applications 6-Methyl-2,3'-bipyridine (cas# 78210-78-3) is a useful research chemical.

Applications (Z)-2-Methoxyimino-2-furanacetic Acid-D3 is an intermediate used in the synthesis of Cefuroxime-d3 (C248052), which is a labeled Cefuroxime (C248050), an anti-bacterial.
References O’Callaghan, C.H., et al.: Antimicrob. Agents Chemother., 9, 511 (1976), Norrby, R., et al.: J. Antimicrob. Chemother., 3, 355 (1977), Brogden, R.N., et al.: Drugs, 17, 233 (1979), Wozniak, J.R., et al.: Anal. Profiles Drug Subs., 20, 209 (1991)

Applications 4-Methylumbelliferyl Butyrate is suitable to use as a fluorogenic substrate for esterases/lipases, such as butyrate esterase.
References M. Vaneechoutte et al. J. Clin. Microbiol. 26, 1227, (1988)

Applications N-Cbz-D-alanine is the Cbz-protected form of D-Alanine (A480995). D-Alanine is an amino acid that is commonly found in bacteria, such as Streptococcus faecalis. It is essential for the biosynthesis of peptidoglycan crosslinking sub-units that are used for bacterial cell walls. D-Alanine is also known to cause cytotoxic oxidative stress in brain tumour cells.
References Ellsworth, B., et al.: Chem. Biol., 3, 37 (1996); Ferrari, E. et al.: Nat. Biotech., 3, 1003 (1985); Stegman, L., et al.: Human Gene Ther., 9, 185 (1998); Wood, W. & Gunsalus, I.: J. Biol. Chem., 190, 403 (1951)

Applications Important building block for the synthesis of peptides containing DAP residues, e.g. bleomycins, edeines, tuberactinomycins.
References Mendre, C., et al.: Tetrahedron Lett., 35, 5429 (1994), Shinagaga, S., et al.: J. Med. Chem., 30, 1458 (1987),

Applications 2-(4-Methylthiazol-5-yl)ethanamine is used in the synthesis and biological testing of several new H2 (Histamine) agonists.
References Timmerman, H., et al.: J. Quant. Struct-Act. Rel., 11, 219 (1992)

Applications A new glutamate analogue as potential neuroprotective agent.
References Takahashi M, et al. 1997. J Exp Biol. Jan;200(Pt 2):401-9. Michaelis EK. 1998. Prog Neurobiol. Mar;54(4):369-415Koch HP, et al. 1999. Mol Pharmacol. Jun;55(6):1044-8 O’Kane RL, et al.1999. J Biol Chem. Nov 5;274(45):31891-5

Applications Fmoc-3,4-dimethoxy-l-phenylalanine