Amino Acids (AA)

<p>Applications 2-Methylalanine is an Alanine (A481400) derivative. Alanine is an amino acid that occurs naturally in nature. It is a functional component in the alanine cycle which regulates the level of alanine aminotransferases which can be used as a diagnostic tool to predict type II diabetes.<br>References Naveed S. et al.: Diab., 53, 11 (2004); Barlind, J. et al.: Bioorg. Med. Chem. Lett., 23, 2721 (2013);<br></p>

<p>Applications D-Homotyrosine hydrobromide<br></p>

<p>Applications 2-Mercapto-4-methyl-5-thiazoleacetic Acid is used as a reagent for determination of hydroxylamine using fused gold nanoparticles immobilized on sol-gel film modified gold electrode.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kannan, P., John, A.: Anal. Chim. Acta, 663, 158 (2010);<br></p>

<p>Stability Hygroscopic<br>Applications Used as a substrate for methionine adenosyltransferase from rat liver.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lombardini, J.B., et al.: Biochem. Pharmacol., 32(3), 489 (1983), Kajander, E., et al.: Cancer Res., 46 (6), 2866 (1986), Kajander, E., et al.: Biochem. J., 267 (3), 767 (1990)<br></p>

<p>Applications It can be degraded efficiently by the QL-degrading bacteria.<br>References Shukla, O., et al.: Microbios., 59, 47 (1989), Oh, Y; Biotechnol Bioeng 1994, 44, 533,,,<br></p>

<p>Applications alpha-Methylene-gamma-valerolactone (cas# 62873-16-9) is a useful research chemical.<br></p>

<p>Applications Dl-lysine monohydrate<br></p>

<p>Applications δ-Valerolactam-d4 is a labeled analog of δ-Valerolactam (V091440), which is a useful synthetic intermediate. It is an intermediate used to synthesize Cenicriviroc (C256550), an experimental drug candidate for the treatment of HIV infection. It is also a starting material for a new route to hexahydrojulolidines, using intramolecular 1,4-cycloaddition.<br>References Potts, K., et al. J. Org. Chem., 58, 5040 (1993); Klibanov, O., et al.: Curr. Opinion Invest. Drugs, 11, 940 (2010);<br></p>

<p>Stability Light Sensitive<br>Applications 3-Methyl-diazirine-3-propanoic Acid is a reagent used in crosslinking sugars and photoactivatable crosslinking.<br>References Tanaka, Y. et al.: J. Am. Chem. Soc., 130, 3278 (2008);<br></p>

<p>Applications 2-hydroxy-3-methylpentanoic acid (cas# 488-15-3) is a useful research chemical.<br></p>

<p>Applications trans 3-(N-Methylanilino)acrolein (cas# 34900-01-1) is a compound useful in organic synthesis.<br></p>

<p>Stability Hygroscopic<br>Applications α-Glycerylphosphorylcholine is a parasympathomimetic acetylcholine precursor which may have potential for the treatment of Alzheimer's disease and other dementias.<br>References Moreno, M., et al.: Clin. Ther., 25, 178 (2003); Parnetti, L., et al.: J. Neurol. Sci., 257, 264 (2007); Doggrell, S., et al.: Expert Opin. Investig. Drugs, 12, 1633 (2003)<br></p>

<p>Applications Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate is used in the synthesis of the major metabolites of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.<br>References Li, X., et. al.: Lett. Org. Chem., 12, 217 (2015); Vallu, V., et. al.: Anal. Chem. Indian J., 14, 339 (2014); Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)<br></p>

<p>Applications 5-Methylfuran-2(3H)-one is an aromatic compound responsible for the aroma of caramel, dried and roated nori, wine, and brewed coffee.<br>References Paravisini, L., et. al.: Flavour Frag. J., 27, 424 (2012); Shu, N., Shen, H.: Flavour Frag. J., 27, 157 (2012); Chin, S., et. al.: J. Chrom. A, 1218, 7487 (2011)<br></p>

<p>Applications 5-amino-2-methyl-benzenesulfonamide (cas# 6973-09-7) is a useful research chemical.<br></p>

<p>Applications 4-Methyl-5-thiazoleethanol-13C3 is used in the synthesis of novel HldE kinase inhibitors used against gram negative bacteria. Also used in the synthesis of potential antimalarial agents from bis-thiazolium analogues. Refer to M330235.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Desroy, N. et al.: J. Med. CHem., 56, 1418 (2013); Caldarelli, S. et al.: J. Med. CHem., 496, (2013);<br></p>

<p>Applications 3,3’-Methylimino-di-propionitrile (cas# 1555-58-4) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-Methyl-7-methylamino-8-nitro-quinoxaline (cas# 78411-55-9) is a compound useful in organic synthesis.<br></p>

<p>Stability Moisture sensitive<br>Applications Hexahydro-4-methylphthalic Anhydride, can be used in the mixture of other isomers nanofiber supported 3D interconnected BN nanosheets for epoxy nanocomposites with ultrahigh thermal management capability<br>References Chen, J., et al.: Adv. Funct. Material., 27, 5 (2017)<br></p>

<p>Applications Labelled 1-Methyl-2-pyrrolidinone (M326120). It is a versatile industrial solvent. NMP is currently approved for use only in veterinary pharmaceuticals. The determination of the disposition and metabolism of NMP in the rat will contribute toward understanding the toxicology of this exogenous chemical which man may likely be exposed to in increasing amounts.<br>References Southwell, D., et al.: J. Pharm. Pharmacol., 33, 3 (1981), Barry, W., et al.: J. Invest. Dermatol., 82, 49 (1984),<br></p>

<p>Impurity Ranitidine EP Impurity H<br>Applications N-Methylnitroacetamide (Ranitidine EP Impurity H) is a degradation product of Ranitidine (R120000).<br>References Sharma, N. et al.: Sci. Pharmac., 79, 309 (2011); Haywood, P.A. et al.: J. Chem. Soc., 5, 951 (1987);<br></p>

<p>Applications Methylpropylnitrosamine is used in biological studies as human liver microsomal cytochrome P-450 enzymes which are involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.<br>References Shimada, T., et al.: Cancer Res., 48, 3218 (1989);<br></p>

<p>Applications N-(Carboxymethyl)-N-[2-[(carboxymethyl)amino]ethyl]-glycine Calcium Salt Hydrate is an intermediate used to prepare copper alkylenediaminetriacetic acid complexes.<br>References Matovic, Z., et al.: Inorganica Chimica Acta, 360, 2420 (2007)<br></p>

<p>Applications An amino acid, first isolated from the juice of watermelon, Citrullus vulgaris Schrad., Cucurbitaceae. Used in the treatment of asthenia.<br>References Kurtz, et al.: J. Biol. Chem., 122, 477 (1938), Rajantie, J., et al.: J. Pediatr., 97, 927 (1980), Carpenter, T.O., et al.: N. Engl. J. Med., 312, 290 (1985),<br></p>

<p>Applications N-Methyl-2-(4-nitrophenyl)ethanamine Hydrochloride is used as a reactant in the preparation of small molecule CDC25 phosphatases inhibitors.<br>References Contour-Galcera, Marie-Odile, et al.: Bioorg. &amp; Med. Chem. Let., 14(23), 5809-5812 (2004)<br></p>

<p>Applications N-Acetylglycine-d5 is an isotopic analog of N-Acetyl-glycine (A178260), a derivative of Glycine (G615990). It is an intermediate used to synthesize rac 3-O-Methyl DOPA (M303805) which is an impurity of Levodopa.<br>References Tabar, et al.: Pharmacol. Biochem. Behav., 33, 139 (1989), De Souza Silva, et al.: J. Neurochem., 68, 233 (1997), Feigin, A., et al.: Neurology, 57, 2083 (2001), Perera, A., et al.: J. Labelled Comp. Radiopharm., 46, 389 (2003),<br></p>

<p>Applications 5-Methylcytosine (cas# 554-01-8) is a useful research chemical.<br></p>

<p>Applications Dl-leucine<br></p>