Amino Acids (AA)

<p>Applications Nα-Boc-L-histidine is an N-Boc-protected form of L-Histidine (H456010). L-Histidine is an essential amino acid that plays an important role in mitochondrial glutamine transport and has potential of abolishing oxidative stress caused by brain edema.L-Histidine promotes zinc uptake in human erythrocyes and also has potential as an antioxidant therapy for acute mammary inflammation in cattle.<br>References Chaiyotwittayakun, A., et al.: J. Dairy Sci., 85, 60 (2002); Horn, N., et al.: J. Phys., 489, 73 (1995); Rama Rao, K., et al.: Am. J. Path., 176, 1400 (2010);<br></p>

<p>Applications 3-N-Methyl-L-histidine is a potential compound to be used as a treatment with pharmacological PPARα agonists to stimulate the ubiquitin proteasome pathway and myofibrillar protein breakdown in skeletal muscle of rodents.<br>References Ringseis, R., et al.: Biochem. Biphys. Gen. Subject., 1830, 2105 (2013); Ubhi, B.K., et al.: Molec. Biosys., 8, 3125 (2012);<br></p>

<p>Applications An essential amino acid found in naturally produced peptides. Unlike its stereoisomer, L-tryptophan, it is not used in structural or enzyme proteins.<br>References Karunakaran, S.et al.: Bochem. J., 414, 343 (2008); Pallaghy, P.K. et al.: Biochem., 38, 11553 (1999);<br></p>

<p>Applications Glycyl-L-Tyrosine Dihydrate is used in process for producing N-Glycyltyrosine. Glycyl-L-Tyrosine Dihydrate is the anhydrous form of Glycyl-L-tyrosine(G720108); which is used in preparation method of high quality Aspartame and Aspartame crystallization-inducing agent.<br>References Mimura, T., et al.: Eur. Pat. Appl., (1999); Gao, Z., et al.: Faming Zhuanli Shenqing, (2019);<br></p>

<p>Applications 1-O-ALPHA-D-GLUCOPYRANOSYL-D-MANNITOL is used in the nutritional and biochemical investigations on disaccharide alcohols.<br>References Grupp, U., et al.: Nutr. Metab., 21, 63 (1977)<br></p>

<p>Applications 5-Methoxy-2-methylaniline (cas# 50868-72-9) is a useful research chemical.<br></p>

<p>Applications 1,2,3-Trichloro-5-methylbenzene is useful in calculating 21 physical properties of organic compounds strictly from molecular structure.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jain, N., et al.: J. Pharm. Sci., 88, 852-860 (1999)<br></p>

<p>Applications 2-Methoxyethanol is used in the synthesis of 2-aminothiazoles in the treatment of prion disease (1). 2-Methoxyethanol is also used in the preparation of Rho-associated kinase inhibitors or (ROCK) inhibitors, for treatment of cardiovascular disease (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Li, Z. et al.: ChemMedChem. 2013 May;8(5):847-57.2. Boland, S. et al.: Bioorg. Med. Chem. Lett. 2013 Dec 1;23(23):6442-6.<br></p>

<p>Applications L-Tyrosine-13C9 ,15N is labelled analogue of L-Tyrosine (T899975), one of the 22 proteinogenic amino acids that are used by cells to synthesize proteins. L-Tyrosine is biologically converted from L-phenylalanine and is in turn is converted to L-DOPA and further converted into the neurotransmitters: dopamine, norepinephrine, and epinephrine.<br>References Rasmussen D.D. et al.: J. Clin. Endocrinol. Metab., 57, 760 (1983); Bagchi, S.P. et al.: Biochem. Pharmacol., 26, 900 (1977)<br></p>

<p>Impurity Paliperidone USP Related Compound A<br>Applications 3-Ethyl-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (Paliperidone USP Related Compound A) is used in the synthesis of Paliperidone (P141000). Intermediate.<br>References Rein, A., et al.: Curr. Opin. Drug Discovery Dev., 3, 734 (2000),<br></p>

<p>Applications AMMONIUM PERFLUORO(2-METHYL-3-OXAHEXANOATE) (cas# 62037-80-3) is a useful research chemical.<br></p>

<p>Applications 2-Methylalanine is an Alanine (A481400) derivative. Alanine is an amino acid that occurs naturally in nature. It is a functional component in the alanine cycle which regulates the level of alanine aminotransferases which can be used as a diagnostic tool to predict type II diabetes.<br>References Naveed S. et al.: Diab., 53, 11 (2004); Barlind, J. et al.: Bioorg. Med. Chem. Lett., 23, 2721 (2013);<br></p>

<p>Applications L-Thioproline is used to create a monolayer on gold electrodes for the determination Copper(II). L-Thioproline has shown to be an effect inhibitor of proline absorption in Saccharomyces chevalieri.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cui, X., et. al.: Sci. China Chem., 53, 257 (2010); Magana-Schwenchke, N., Schwencke, J.: BBA-Biomembranes, 173, 313 (1969)<br></p>

<p>Applications 2-Methyl-d3-propyl-3,3,3-d3 Alcohol (CAS# 72182-69-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 7-Methoxy-3,4-dihydro-1-naphthalenyl-acetonitrile (cas# 861960-34-1) is a compound useful in organic synthesis.<br></p>

<p>Applications α-(2,3-Dimethylphenyl)-α-methyl-1H-imidazole-5-methanol is used as a reagent in the synthesis of Medetomidine (M203250); an α2-adrenergic agonist. Also a sedative and analgesic.<br>References Scheinin, M., et al.: Br. J. Clin. Pharmacol., 24, 443 (1987); Stenberg, D., et al.: J. Vet. Pharmacol. Ther., 10, 319 (1987); Virtanen, R., et al.: Eur. J. Pharmacol., 150, 9 (1988); Cullen, L.K., et al.: Br. Vet. J., 152, 519 (1996); Chen, W., et al.: Faming Zhuanli Shenqing. CN 101921234 A 20101222. Dec 22, 2010<br></p>

<p>Applications A labelled product of L-Tryptophan metabolism, possessing neruoactive activity having antiexcitotoxic and anticonvulsant properties.<br>References Wejksza, K., et al.: Pharmacol. Rep., 61, 751 (2009), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010), Di Natale, B., et al.: Toxicol. Sci., 115, 89 (2010),<br></p>

<p>Applications 2-Amino-5-chloro-3-methylbenzoic Acid is a useful research chemical for the preparation of benzoyl urea containing anthranillic acid groups with insecticidal activity.<br>References Peng, Y., et al.: Nongyao, 48, 326 (2009);<br></p>

<p>Stability Very Volatile<br>Applications 2-Methoxy Propane is a synthetic intermediate used for the preparation of various biosynthetic molecules and pharmaceutical goods.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gharagheizi, F., et al.: Indust. Engin. Chem. Res., 51, 6265 (2012); Vandendriessche, S., et al.: Phy. Chem. Chem. Phy., 14, 1860 (2010); Moon, J.K., et al.: J. Agr. Food. Chem., 58, 5465 (2010);<br></p>

<p>Stability Hygroscopic<br>Applications 1,2-Cyclohexanedicarboxylic Acid Mono 4-Methyl-7-carboxy-heptyl Ester is a possible metabolite of the di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH) monoester (MINCH).<br>References Koch, H., et al.: Arch. Toxicol., 87, 799 (2013)<br></p>

<p>Applications Methionine-methyl-d3 is the labeled Methionine-methyl, a useful building block.<br></p>

<p>Applications 2-Bromo-4-methylphenol is a useful synthetic intermediate. It was used in the synthesis of furan-2-ylmethylene thiazolidinediones as potent, and selective inhibitors of phosphoinositide 3-kinase γ. It was also a reactant used to prepare phosphoramidate and phosphorothioamidate analogs of amiprophos Me as potential antimalarial agents.<br>References Pomel, V., et al.: J. Med. Chem., 49, 3857 (2006); Mara, C., et al.: Bioorg. Med. Chem. Lett., 21, 6180 (2011)<br></p>

<p>Applications 6-Methylpurine (cas# 2004-03-7) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 5-((2-Hydroxyethyl)amino)-2-methylphenol (cas# 55302-96-0) is a useful research chemical.<br></p>

<p>M03001 - H-Gly-OH</p>

<p>Applications 8-Chloro-4-hydroxy-2-methylquinoline (cas# 5236-87-3) is a useful research chemical.<br></p>

<p>Applications Labelled 4-Methylimidazole (M312990). 4-Methylimidazole is a monomethylated imidazole that can be used as a building block in the preparation of a wide range of biologically active compounds. 4-Methylimidazole is a product which results from the interaction of reducing sugars with ammonia. 4-Methylimidazole showed convulsant activity in animals and is listed as a possible carcinogen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nishie, K. et al.: Toxicol. Appl. Pharmacol., 14, 301 (1969): Cunha, S.C. et al.: J. Food Comp. Anal., 24, 609 (2011); Chan, P.C. et al.: Arch. Toxicol., 82, 55 (2008);<br></p>