Amino Acids (AA)

<p>Applications N-Benzyloxycarbonyl L-Threonine Amide O-Methanesulfonate (cas# 80082-51-5) is a compound useful in organic synthesis.<br></p>

<p>Applications trans 3-(N-Methylanilino)acrolein (cas# 34900-01-1) is a compound useful in organic synthesis.<br></p>

<p>Applications (S)-2-Amino-4-[(3-aminopropyl)amino]-butanoic Acid is used in the reaction of carboxynorspermidine decarboxylase of Vibrio alginolyticus.<br>References Nakao, H., et al.: J. Gen. Microbiol. 136, 1699-704 (1990)<br></p>

<p>Applications N-Methyl-N-nitroso Urea-d6 is the labelled form of N-Methyl-N-nitroso Urea (M325815), which is a precursor of Diazomethane. It has a cytotoxicity effect.<br>References Huggins, C., et al.: J. Exp. Med., 131, 321 (1970); Gullino, P.M., et al.: J. Natl. Cancer Inst., 54, 401 (1975)<br></p>

<p>Applications D-Aspartic Acid Dimethyl Ester Hydrochloride is a useful synthetic intermediate in the synthesis of MK-7246 (M425045); a potent and selective CRTH2 antagonist for the treatment of respiratory diseases.<br>References Molinaro, C., et al.: J. Org. Chem., 77, 2299 (2012); Gervais, F.G., et al.: Mol. Pharmacol., 79, 69 (2011); Gallant, M, et al.: Bioorg. Med. Chem. Lett., 21, 288 (2011)<br></p>

<p>Applications N-Succinimidyl 3-Methoxy-4-nitrobenzoate (cas# 2006277-78-5) is a useful research chemical.<br></p>

<p>Applications A labelled metabolite of Crotonaldehyde.<br>References Gray, J.M., et al.: Xenobiotica, 1, 55 (1971), Chung, F., et al.: Mutat. Res., 424, 71 (1999), Smith, C., et al.: Food Chem. Toxicol., 38, 637 (2000), Pan, J., et al.: Chem. Res. Toxicol., 15, 367 (2002),<br></p>

<p>Applications Substrate for TenA enzyme in the thiamin salvage pathway<br>References Jenkins, A., et al.: Nat. Chem. Biol., 3, 492 (2007), Jenkins, A., et al.: Bioorg. Chem., 36, 29 (2008),<br></p>

<p>Applications 4-Methyl-5-thiazoleethanol-13C3 is used in the synthesis of novel HldE kinase inhibitors used against gram negative bacteria. Also used in the synthesis of potential antimalarial agents from bis-thiazolium analogues. Refer to M330235.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Desroy, N. et al.: J. Med. CHem., 56, 1418 (2013); Caldarelli, S. et al.: J. Med. CHem., 496, (2013);<br></p>

<p>Applications 12-(t-Boc-amino)-1-dodecanol (cas# 67341-03-1) is a compound useful in organic synthesis.<br></p>

<p>Applications β-Alanine-13C3,15N is the isotope labeled analogue of β-Alanine (A637320), which is a naturally occurring beta amino acid. β-Alanine is formed in vivo by the degradation of Dihydro Uracil (D449990) and Carnosine. β-Alanine is also the rate-limiting precursor of Carnosine, as a result supplementation with β-Alanine increases the concentration of Carnosine in muscles.<br>References Derave, W. et al.: J. Appl. Physiol., 103, 1736 (2007); Xia, J.-F. et al.: J. Chrom. B Anal. Technol. Biomed. Life Sci., 977, 1930 (2009); Artioli, G.G. et al.: Med. Sci. Sports Exer.,42, 1162 (2010);<br></p>

<p>Applications 2-Methyl-4-oxo-4-phenylbutyric Acid is a chemical reagent used in the synthesis of various pharmaceutically active compounds. Used in the synthesis of Minozac, a suppressor of brain proinflammatory cytokine up-regulation.<br>References Hu, W. et al.: Bioog. Med. Chem. Lett., 17, 414 (2007); Qabaja, G. ET AL.: J. ORG. CHEM., 80, 133 (2015);<br></p>

<p>Applications β-Hydroxyisobutanol is used as a reagent in the synthesis of pyrazolo[1,5-a]pyridinecarbonyl-substituted spirocyclic piperidine ketals as inhibitors of HCV protein NS4B and of hepatitis C viral replication and their lack of cytotoxicity in human cells.<br>References Tai, V.W.-F., et al.: Bioorg. Med. Chem. Lett., 24, 2288 (2014);<br></p>

<p>Stability Hygroscopic<br>Applications Hexanoyl-L-carnitine-(N-methyl-d3) Chloride, is the labeled analogue of Hexanoyl-L-carnitine Hydrochloride (H294440), which is used as reactant in the synthesis of carnitine benzyl esters as prodrugs.<br>References Gong, X., et. al.: J. Chem. Res., 6, 327 (2008)<br></p>

<p>Applications 2,4,8,10-Tetraoxaspiro[5.5]undecane-3,9-diylbis(2-methylpropane-2,1-diyl) bis(3-(3-(tert-butyl)-4-hydroxy-5-methylphenyl)propanoate) (cas# 90498-90-1) is a useful compound used as a modifier for the thermo-oxidative stabilization of synthesized meterials such as polypropylene-based materials, and spider silk.<br>References Matta, A.; et al.: Polym. Degrad. Stab., 142, 50 (2017); Dao, A. T.; et al.: Polym. Degrad. Stab., 153, 37 (2018).<br></p>

<p>Applications (±)-3-Amino-iso-butyric-2,3,3-d3 Acid is the labeled version of DL-3-Aminoisobutyric Acid (A603043(P)), which is a useful compound for suppressing atherosclerosis in apolipoprotein E-knockout mouse.<br>References Shimba, Y., et al.: Bio. Pharma. Bull., 43, 1016 (2020)<br></p>

<p>Applications 3-(methyl-d3)-1H-Indole-2,4,5,6,7-d5 is the labeled analogue of 3-Methylindole (M313470), a naturally abundant pneumotoxin, found primarily in mammalian feces providing its strong fecal odor; however in lower concentrations the compound has a pleasent aroma, giving orange blossoms and jasmine their pleasing scent. It is often a component of commercial fragrances and perfumes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nakashima, T., et al.: Biol. Pharm. Bull., 32, 832 (2009), Xu, H., et al.: Chem. Pharm. Bull., 57, 321 (2009), Bodoor, K., et al.: J. Med. Chem., 52, 3753 (2009), Naskar, S., et al.: J. Chem. Res., 3, 174 (2009), Sollner, K., et al.: J. Agric. Food Chem., 57, 4319 (2009),<br></p>

<p>Stability Air Sensitive<br>Applications 4-Chloro-2-methylaniline<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-Methyl-7-methylamino-8-nitro-quinoxaline (cas# 78411-55-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine is a reagent in the synthesis and structure-activity relationship studies of highly potent novel benzoxazinyl-oxazolidinone which is an antibacterial agent. Benzoxazinyl-oxazolidinone had potent activity against Gram-positive pathogens. 5-Bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine is also an intermediate in the synthesis of Tedizolid (T013750).<br>References Xin, Q., et al.: J. Med. Chem., 54, 7493 (2011)<br></p>

<p>Stability Moisture sensitive<br>Applications Hexahydro-4-methylphthalic Anhydride, can be used in the mixture of other isomers nanofiber supported 3D interconnected BN nanosheets for epoxy nanocomposites with ultrahigh thermal management capability<br>References Chen, J., et al.: Adv. Funct. Material., 27, 5 (2017)<br></p>

<p>Applications 1-Methyl-4-nitropyrrole-2-carboxylic Acid is used in the synthesis of Lexitropsin and distamycin analogs with antimicrobial activities.<br>References Anthony, N., et al.: J. Med. Chem., 50, 6116 (2007); Khalaf, A., et al.: J. Med. Chem., 47, 2133 (2004)<br></p>

<p>Applications 4-(4-Methoxyphenyl)-2-butanone is also used in the synthesis of novel axially chiral Rh-NHC complexes. Used to synthesize carbonyl complexes as novel traceless linkers.<br>References Duan, W. et al.: Chem. Comm., 23, 2916 (2003); Gibson, S. et al.: Tetrahedron. Lett., 40, 1417 (1999);<br></p>

<p>Applications L-Glutamic acid dibenzyl ester 4-toluenesulfonate<br></p>

<p>Applications (4-Methylphenyl)-2-pyridinylmethanone is a useful reactant in organic synthesis.<br>References Hu, Zhiyuan, et al.: Org. &amp; Biomol. Chem., 16(31), 5653-5660 (2018);Liao, Yang, et al.: J. of Organometallic Chem., 881, 1-12 (2019)<br></p>

<p>Applications 2,4-Dinitrophenylhydrazone (DNPH) derivative.<br>References Lindsay, R.C., et al.: J. Food Sci., 29, 266 (1964),<br></p>

<p>Impurity Cefalexin EP Impurity D<br>Applications 3-Hydroxy-4-methyl-2(5H)-thiophenone (Cefalexin EP Impurity D) is an acid degradation product of Cephalexin (C256800) and Cefaclor (C235250), antibiotics.<br>References Dinner, A.: J. Med. Chem. 20, 963 (1977); Baetschi, S.W., et. al.: J. Pharmaceut., Sci., 86, 526 (1997)<br></p>

<p>Applications Zinc Glycinate is used in the preparation of hydroxy acid complexes used in skin antiaging, acne and skin whitening formulations.<br></p>

<p>Applications S-Methyl-L-cysteine is a substrate in the catalytic antioxidant system mediated by methionine sulfoxide reductase A (MSRA). It has been studied as a theurapeutic for neurodegenerative diseases including Parkinson′s.<br>References Wassef, R., et al.: J. Neurosci., 21, 12808 (2007)<br></p>

<p>Applications L-Threonic acid calcium salt is the salt of L-Threonic acid, a naturally occurring compound that can be found in the leaves of Pelargonium crispum. L-Threonic acid is also the degradation product of Dehydroascorbate (DHA), a metabolite of Vitamin C (A786990).<br>References Helsper, J. &amp; Loewus, F.: Plant Phys., 69, 1365 (1982); Koch, C. &amp; Biaglow, J.: J. Cell. Phys., 94, 299 (1978); Nielsen J., et al.: J. Agr. Food Chem., 49, 2998 (2001)<br></p>

<p>Impurity Piroctone USP Related Compound B<br>Applications 4-Methyl-6-(2,4,4-trimethylpentyl)-2H-pyran-2-one is used in the synthesis of antibacterials and antimycotics. Related to Piroctone (P509400), an anti-dandruff agent used in shampoo formulations. Piroctone USP Related Compound B<br>References Georgalas, A. et al.: J. Cosm. Sci., 55, S207 (2004); Mayser, P. et al.: J. Cosm. Sci., 54, 263 (2008);<br></p>

<p>Applications 6-Methylquinoline, is a building block used for the synthesis of various pharmaceutical compounds, and biologically active compounds. It can be used for the preparation of pyranobenzopyrone compounds, having anti-norovirus activity.<br>References Pokhrel, L., et al.: bioorg. Med. Chem. Lett., 22, 3480 (2012);<br></p>