Amino Acids (AA)

<p>Applications 3-Methyl-3-hepten-5-one is a reagent used to prepare fused nitrogen-heterocycles from β-enamino nitrile and α,β-unsaturated carbonyl compounds.<br>References Nemes, P., et al.: Synlett., 2, 222 (1999)<br></p>

<p>Applications 2-Hydroxy-2-methylpropanamide (cas# 13027-88-8) is a useful research chemical.<br></p>

<p>Applications Protected L-Tyrosine (T899975), an amino acid, used by cells to synthesize proteins. L-Tyrosine is biologically converted from L-phenylalanine and is in turn is converted to L-DOPA and further converted into the neurotransmitters: dopamine, norepinephrine, and epinephrine.<br>References Rasmussen D.D. et al.: J. Clin. Endocrinol. Metab., 57, 760 (1983); Bagchi, S.P. et al.: Biochem. Pharmacol., 26, 900 (1977)<br></p>

<p>Applications N-Methyl-L-alanine is a reactant used in the preparation of site-specific trastuzumab maytansinoid antibody-drug conjugates with improved therapeutic activity.<br>References Pillow, T.H., et. al.: J. Med. Chem., 57, 7890 (2014)<br></p>

<p>Stability Very Hygroscopic<br>Applications Hydroxyisovaleroyl Carnitine is used as a diagnostic tool to identify the presence of orofacial clefts. Also used in the screening and diagnostics of inborn errors of metabolism.<br>References Denes, J. et al.: Anal. Chem., 84, 10113 (2012); Budner, M. et al.: Arch. Oral. Biol., 58, 459 (2013);<br></p>

<p>Applications (S)-2-Amino-4-methylpentanol is a starting material for the synthesis of aminopeptidase N and phospholipase A2 inhibitors.<br>References Fournié-Zaluski, M., et al.: J. Med. Chem., 35, 1259 (1992); Bennion, C., et al.: J. Med. Chem., 35, 2939 (1992)<br></p>

<p>Stability Hygroscopic<br>Applications 7-CHLORO-L-TRYPTOPHAN (cas# 73945-46-7) is a useful research chemical.<br></p>

<p>Applications L-2-Aminobutyric Acid-d6 is the isotope labelled analog of L-2-Aminobutyric Acid (A602930); a receptor antagonist.<br>References Porter, D.J.T., et al.: Biochem. Pharmacol., 50, 1475 (1995)<br></p>

<p>Applications Methionine-methyl-d3 is the labeled Methionine-methyl, a useful building block.<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Melatonin (M215000).<br>References Reiter, R.J., et al.: J. Biomed. Sci., 7, 444 (2000), Chen, Z., et al.: Am. J. Physiol, 284, 1618 (2003), Barrenetxe, J., et al.: J. Physiol. Biochem., 60, 61 (2004),<br></p>

<p>Impurity Cefoperazone EP Impurity C<br>Applications N-Methyl-5-tetrazolethiol (Cefoperazone EP Impurity C) is an impurity of Cefoperazone.<br>References Kitson, T., et al.: Biochem. J., 175, 83 (1978), Elenbaas, R., et al.: Clin. Pharmacol. Ther., 32, 347(1982),<br></p>

<p>Applications 2-(Diphenylmethoxy)-N-methylethylamine is used in the pereparation of H1 and H2 receptor antagonists containing Diphenhydramine (D486900) derivatives. Diphenhydramine is a H1-histamine receptor antagonist. Diphenhydramine (D486900) is categorized as an antihistaminic; sedative, hypnotic.<br>References Wolf, C. et al.: Archiv. de Pharm., 329, 87 (1996); Gruhzit, O.M., et al.: J. Pharmacol. Exp. Ther., 89, 227 (1947), Holcomb, I.J., et al.: Anal. Profiles Drug Subs., 3, 173 (1974), Scavone, J.M., et al.: J. Clin. Pharmacol., 38, 603 (1998),<br></p>

<p>Stability Volatile<br>Applications 3-ETHYL-3-METHYLHEPTANE (cas# 17302-01-1) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications L-(+)-2-Phenylglycine is a derivative of Glycine (G615990), the smallest of all the amino acids, and is also used to treat schizophrenia, stroke, and benign prostatic hyperplasia. L-(+)-2-Phenylglycine is also used as an N-linked side chain of an SMTP (Stachybotrys microspora tripenyl phenols) congener, which was potent in enhancing plasminogen activation in S. microspora.<br>References Gusev, E., et al.: Cerebrovasc. Dis., 10, 49 (2000); Koide, H., et al.: J. Antibiot., 65, 91 (2012); Rosse, R., et al.: Clin. Neuropharmacol., 12, 416 (1989); Tuszynski, G., et al.: Lab. Invest., 70, 228 (1994)<br></p>

<p>Applications A naturally occurring nitrostable secondary amine found in tabacco smoke condensate.<br>References Singer, G.M. et al.: J. Agric. Food Chem. 24, 553(1976); Bush, L. P. et al.: Can. J. Plant Sci. 50, 289(1970).<br></p>

<p>Applications N-Boc-piperazine-d8 is a useful synthetic intermediate for the preparation of labelled compounds.<br></p>

<p>Stability Hygroscopic<br>Applications Used as a substrate for methionine adenosyltransferase from rat liver.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lombardini, J.B., et al.: Biochem. Pharmacol., 32(3), 489 (1983), Kajander, E., et al.: Cancer Res., 46 (6), 2866 (1986), Kajander, E., et al.: Biochem. J., 267 (3), 767 (1990)<br></p>

<p>Applications A metabolite of Crotonaldehyde.<br>References Gray, J.M., et al.: Xenobiotica, 1, 55 (1971), Chung, F., et al.: Mutat. Res., 424, 71 (1999), Smith, C., et al.: Food Chem. Toxicol., 38, 637 (2000), Pan, J., et al.: Chem. Res. Toxicol., 15, 367 (2002),<br></p>

<p>Applications It can be degraded efficiently by the QL-degrading bacteria.<br>References Shukla, O., et al.: Microbios., 59, 47 (1989), Oh, Y; Biotechnol Bioeng 1994, 44, 533,,,<br></p>

<p>Applications 3-Methoxy-1,2-propanediol is used to prepare phosphorothioate analogs of sn-2 radyl lysophosphatidic acid as metabolically stabilized LPA receptor agonists. It is also used to synthesize diacylglycerol analogs as potential second-messenger antagonists.<br>References Jiang, G., et al.: Bioorg. Med. Chem. Lett., 23, 1865 (2013); Briggs, J., et al.: Bioorg. Med. Chem. Lett., 2, 127 (1992)<br></p>

<p>Applications Cucumopine is used in biological studies to evaluate Agrobacterium rhizogenes cucumopine strain T-DNA ORF8 and its effects on transgenic tobacco root cultures.<br>References Bonfill, M., et al.: Curr. Top. Plant Biol., 3, 223 (2002);<br></p>

<p>M03001 - H-Gly-OH</p>

<p>Applications N-Acetyl-S-benzyl-d5-L-cysteine is deuterium labelled N-Acetyl-S-benzyl-L-cysteine, which is a metabolite of toluene.<br>References Gargas, M., et al.: Toxicol. Appl. Pharmacol., 98, 87 (1989), Commandeur, J., et al.: Pharmacol. Rev., 47(2), 271 (1995), Campo, P., et al.: Neurotoxicol. Teratol., 21, 427 (1999), Lohse, C., et al.: J. Agr. Food Chem., 48, 5913 (2000),<br></p>

<p>Stability Moisture Sensitive<br>Applications An inhibitor of alkaline phosphatase isoenzymes. An analog of Homoarginine (H585000).<br>References Muth, W., et al.: J. Biol. Chem., 249, 7463 (1974), Hanukoglu, I., et al.: Eur. J. Biochem., 180, 479 (1989), Khaw, L., et al.: J. Bacteriol. 180, 809 (1998), Gallagher, D., et al.: J. Mol. Biol., 342, 119 (2004),<br></p>

<p>Applications Tetrahydro-5-methyl-2-furanol is an intermediate in synthesizing 2,3-Dihydro-2-methylfuran (D447355), which is a general reagent used in next generation of biofuels. Dihydrofuranyl derivative.<br>References Simmie, J. et al.: J. Phys Chem., 116, 4528 (2012);<br></p>

<p>Applications 4-Methyl-1-[3-nitro-5-(trifluoromethyl)phenyl]-1H-imidazole, is a 4-methyl-1H-imidazole (4-MEI) derivative.<br></p>

<p>Applications 6-Methylmercaptopurine Riboside (cas# 342-69-8) is a compound useful in organic synthesis.<br></p>