Amino Acids (AA)

<p>Applications 3-Methyl-5-(3-nitrophenyl)cyclohex-2-enone is derived from Acetone (A163800), which is a common organic building block in organic chemistry.<br>References Neubert, L., et al.: J. Am. Chem. Soc., 134, 12239 (2012); Zhai, J.J., et al.: J. Am. Soc. Mass. Spec., 20, 1366 (2009);<br></p>

<p>Applications (4R,6S)-rel-5,6-Dihydro-4-hydroxy-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-Dioxide is used as a reactant in the preparation of Dorzolamide Hydrochloride (D535100), which is a carbonic anhydrase inhibitor; antiglaucoma agent.<br>References Lippa, E.A., et al.: Ophthalmology, 98, 308 (1991); Wang, R.-F., et al.: Arch. Ophthalmol., 109, 1297 (1991); Whikehart, D., et al.: J. Ocul. Pharmacol., 7, 195 (1991); Sjoquist, B., et al.: Drug Metab. Dispos., 26, 745 (1998);<br></p>

<p>Applications 4-Methyl-valerophenone is an intermediate used in the synthesis of a-Pyrrolidinoisohexanophenone (Hydrochloride) (P841230), which is a phenone derivative used for research purposes.<br>References Guo, Z.K., et al.: Marine Drugs, 16, 45/1 (2018)<br></p>

<p>Applications Hydroxyprolines are valuable chiral building blocks for organic synthesis of pharmaceuticals. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.<br>References Lawrence, C., et al.: Biochem. J., 313, 185 (1996), Mori, H., et al.: J. Bacteriol., 179, 5677 (1997), Clifton, I., et al.: Eur. J. Biochem., 268, 6625 (2001),<br></p>

<p>Applications N-Acetyl-L-cystine is an antioxidant, used in the treatment of influenza A virus pandemic (1). N-Acetyl-L-cystine promotes fertilization by reducing disulfide bonds in zona pellucida of mouse (2).Releases N-Acetyl-L-cysteine, which is an antidote for paracetamol poisoning.<br>References (1) Zhang, R., et al.: (2014) Int. Immunopharmacol. 22: 1-8 (2) Takeo, T., et al.: Biol Reprod. (2015) 92: 1-7<br></p>

<p>Applications 5-(2-Hydroxyethylamino)-2-methoxylaniline sulfate (cas# 83763-48-8) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications D-Tyrosine-d2 is deuterium labelled D-Tyrosine (T899970). D-Tyrosine, the stereoisomer to L-Tyrosine (T899975), is an amino acid used in various organic syntheses for antibiotics. It is used in the synthesis of (-)-anisomycin, as well as BATSI (boronic acid transition state inhibitors) which act on β-lactamases. It has also been studied as an inhibitor of microbial growth on surfaces, reducing microbial attachment to hydrophillic glass and hydrophobic polypropylene surfaces.<br>References Li, Ji. et al.: Chin. Chem. Lett., 23, 647 (2012); Xu, H. et al.: Water Res., 45, 5796 (2011); Ke, W. et al.: Antimicrob. Agents Chemother., 55, 174 (2011)<br></p>

<p>Applications D-Homophenylalanine<br></p>

<p>Applications Guaiacol-beta-D-glucopyranoside, is a Guaiacol Conjugate, that has shown to present in fermentation of grapes that had been exposed to bushfire smoke and can potentially yield unpalatable, smoke-affected wine.<br>References Hayasaka, Y.m et al.: J. Arg. Food Chem., Vol. 58, Issue 4, P: 2076; 2081 (2010);<br></p>

<p>Applications A non-essential amino acid found in food sources and dietary supplements. Its conjugate base D-aspartate has potential use as a a therapeutic agent in the treatment of schizophrenia-related symptoms.<br>References Errico, F. et al.: J. Neurosci., 28, 10404 (2008); Denu, J.M. et al.: Biochem., 34, 3396 (1995); Chen, P.E. et al.: Mol. Pharmacol., 67, 1470 (2005);<br></p>

<p>Applications 1-(3-ACETYL-2-HYDROXY-5-METHYL-PHENYL)-ETHANONE (cas# 55108-28-6) is a useful research chemical.<br></p>

<p>Impurity Rifaximin EP Impurity A<br>Applications 2-Amino-4-methylpyridine (Rifaximin EP Impurity A) is an impurity of Rifaximin.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Methyl 4-Methoxysalicylate, is an organic building block, used for the synthesis of (+)-coriandrone A and B, two bioactive natural products. It can also be used for the preparation of Dimethoxybenzofuran derivatives as potent and selective inhibitors of CYP2A6.<br>References Wang, W., et al.: Org. Biomol. Chem., 11, 6686 (2013); Yamaguchi, Y., et al.: Heterocycles, 87, 1727 (2013);<br></p>

<p>Stability Hygroscopic, Light Sensitive<br></p>

<p>Applications 2-Methoxyethyl 3-oxobutanoate (cas# 22502-03-0) is a useful research chemical.<br></p>

<p>Applications 2-Methoxypropene is used in the synthesis of Macrolactin A, a 24-member macrolide typically employed as an antibiotic. Also used in the synthesis of phenylalanine derivatives used as α4β1 and α4β7 receptor antagonists in the treatment of allergic asthma.<br>References Marino, K. et al.: J. Am. Chem. Soc., 12, 1664, (2002); Tilley, J. et al.: Bioorg. Med. Chem. Lett., 23, 1036 (2013);<br></p>

<p>Applications 4-Amino-2-methyl-5-pyrimidinemethanesulfonic acid is used in the biosynthesis of Thiamine (T344185) in yeast.<br>References White, R., et al.: Journal of the American Chemical Society, 104, 4934 (1982).<br></p>

<p>Applications L-Methionine-3,3,4,4-d4 (CAS# 67866-75-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,6-Diaminopimelic Acid is useful in biological studies involving amino acids and amino sugars as molecular indicators of the origins of organic matter in buried tephra soils.<br>References Hobara, S., et al.: Geoderma, 373, 114449 (2020)<br></p>