Amino Acids (AA)

<p>Applications 2-HYDROXY-N,N-DIMETHYLACETAMIDE (cas# 14658-93-6) is a useful research chemical.<br></p>

<p>Applications Important building block for the synthesis of peptides containing DAP residues, e.g. bleomycins, edeines, tuberactinomycins.<br>References Thuring, J., et al.: Biochem., 41, 2002 (2002), Hausch, F., et al.: Chem. Biol., 10, 225 (2003), Palucki, B., et al.: Bioorg. Med. Chem. Lett.,15, 1993 (2005),<br></p>

<p>Applications 2-(1-Methylpiperidin-3-yl)ethan-1-ol (cas# 101257-32-3) is a useful reagent for preparing 3-(ω-hydroxyalkyl)-substituted N-methylpiperdines and N-methyl-2-piperidones.<br>References Schneider, W., et al.: Archiv der Pharmazie., 300, 540 (1967)<br></p>

<p>Applications: 4-Methoxy-[7-13C]-benzoic Acid (cas# 69838-89-7) is a compound useful in organic synthesis.<br></p>

<p>Applications L-Valine Benzyl Ester is a L-Valine derivative useful as intermediate for the preparation of peptides.<br>References Kimura, S., et al.: Int. J. Biol. Macromolec., 3, 225 (1981),<br></p>

<p>Applications Proteolysis Targeting Chimera (PROTAC) is a novel approach to modern drug development programs that utilizes small compounds to target proteins for ubiquitination and degradation by proteasome. 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(1-piperazinyl)propoxy]-3-quinolinecarbonitrile is a PROTAC compound, which has the potential to target oncogenic BCR-ABL for degradation. 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(1-piperazinyl)propoxy]-3-quinolinecarbonitrile has also been employed in ligand-based pharmacophore modelling to identify c-Src inhibitors.<br>References Lai, A. C., et al., Angew. Chem. Int. Ed. 55, 807 (2016); Sakkiah, S., et al., J. Enzyme Inhib. Med. Chem. 29, 69 (2014)<br></p>

<p>Applications Isotope labelled D-Proline (P755990), which is used in the synthesis of (R)-(+)-N-Boc-Pipecolic Acid, (S)-(-)-Coniine, (S)-(+)-Pelletierine, (+)-.beta.-Conhydrine, and (S)-(-)-Ropivacaine and formal synthesis of (-)-Lasubine II and (+)-Cermizine C.<br>References Gawley, R., et al.: Org. Biomol. Chem., 4, 4285 (2006),<br></p>

<p>Stability Moisture Sensitive - Store Under Inert Atmosphere<br>Applications 3-Methyl-8-quinolinesulfonyl Chloride (cas# 74863-82-4) is a compound useful in organic synthesis.<br></p>

<p>Applications Intermediate in the preparation of labelled Trimebutine metabolites.<br></p>

<p>Applications 3-Dimethylamino-1-(3-methoxyphenyl)propan-1-one is an intermediate in the synthesis of Oxyfedrine (O870700), which acts as a vasodilator affecting the coronary base flow.<br>References Baraka, Y. et al.: J. Drug Res., 12, 161 (1980);<br></p>

<p>Applications L-Anserine-d4 (N-beta-alanyl-d4) is a useful isotopically labeled research compound. It can be used as an internal standard in LC-MS.<br>References Gopinathan, M. B., et al.: Synth. Commun., 39, 3973 (2009)<br></p>